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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Book Description
Author: Archie W. Prestayko
Publisher: Academic Press
ISBN: 1483289001
Category : Science
Languages : en
Pages : 544
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Book Description
Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetics of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Book Description
Author: Jeanne A. Mowry
Publisher:
ISBN:
Category :
Languages : en
Pages : 4
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Book Description
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 848
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Book Description
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author: Archie W. Prestayko
Publisher:
ISBN:
Category :
Languages : en
Pages : 527
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Book Description
Author: Paul H. Sugarbaker
Publisher:
ISBN: 9781461526056
Category :
Languages : en
Pages : 348
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Book Description
Author: Aparajita Dey
Publisher: Springer Science & Business Media
ISBN: 9400758812
Category : Medical
Languages : en
Pages : 269
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Book Description
The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
Author: Letícia Rangel
Publisher: BoD – Books on Demand
ISBN: 9535121944
Category : Medical
Languages : en
Pages : 287
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Book Description
In spite of advances in the cancer research field, cancer treatment still challenges researchers and clinicians, as proven by the still impressive and increasing number of worldwide cancer-related deaths. Updates on Cancer Treatment is an attempt to integrate into a book volume various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field.
