Cholinesterases and Anticholinesterase Agents PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Cholinesterases and Anticholinesterase Agents PDF full book. Access full book title Cholinesterases and Anticholinesterase Agents by George B. Koelle. Download full books in PDF and EPUB format.
Author: George B. Koelle
Publisher: Springer Science & Business Media
ISBN: 3642998755
Category : Medical
Languages : en
Pages : 1228
Get Book Here
Book Description
Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.
Author: George B. Koelle
Publisher: Springer Science & Business Media
ISBN: 3642998755
Category : Medical
Languages : en
Pages : 1228
Get Book Here
Book Description
Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.
Author: A.S. Balasubramanian
Publisher: Springer Science & Business Media
ISBN: 1489910514
Category : Science
Languages : en
Pages : 524
Get Book Here
Book Description
The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.
Author: Bhupendra P. Doctor
Publisher: Springer Science & Business Media
ISBN: 1489915400
Category : Medical
Languages : en
Pages : 627
Get Book Here
Book Description
The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.
Author: Ann Silver
Publisher: North-Holland
ISBN:
Category : Medical
Languages : en
Pages : 620
Get Book Here
Book Description
Author: Ezio Giacobini
Publisher: CRC Press
ISBN: 9781853179105
Category : Science
Languages : en
Pages : 280
Get Book Here
Book Description
With the collaboration of the most distinguished scholars in this field Professor Giacobini has put together a publication which will convey present knowledge in the field of molecular biology and genetics, biochemistry, cell biology, pharmacology and toxicology as well of clinical applications (particularly in the field of Alzheimer's disease therapy) of cholinesterase inhibitors. In a concise but precise manner it condenses our present knowledge of these enzymes and their inhibitors and helps those who want to understand them as well as to utilize them for therapeutic purposes.
Author: Charles R. Crane
Publisher:
ISBN:
Category : Blood
Languages : en
Pages : 20
Get Book Here
Book Description
Author: Hermona Soreq
Publisher: Academic Press
ISBN: 0323155731
Category : Science
Languages : en
Pages : 331
Get Book Here
Book Description
Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.
Author:
Publisher: ScholarlyEditions
ISBN: 1464925550
Category : Medical
Languages : en
Pages : 182
Get Book Here
Book Description
Cholinesterases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cholinesterases. The editors have built Cholinesterases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cholinesterases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cholinesterases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Serge N. Moralev
Publisher: Internat'l University Line
ISBN: 9780972077422
Category : Medical
Languages : en
Pages : 522
Get Book Here
Book Description
Author: M. A. Gerebtzoff
Publisher: Elsevier
ISBN: 148322127X
Category : Science
Languages : en
Pages : 205
Get Book Here
Book Description
Modern Trends in Physiological Sciences, Volume 3: Cholinesterases: A Histochemical Contribution to the Solution of Some Functional Problems covers the histochemical aspects of humoral and tissue cholinesterases, both inside and outside of the nervous system. This volume is composed of three part encompassing 14 chapters. The first part describes the link between cholinesterases and serum and between acetylcholinesterase and erythrocytes. This part also deals with the histochemical measurement of acetylcholinesterase activity in the erythrocytes or platelets of some mammalian species, with an emphasis on delineating the possible role of this enzyme in maintaining the integrity of these cells. The remaining two parts discuss the convergence of morphological, physiological, and biochemical research on tissue cholinesterases. These parts also describe the general features of the localization of cholinesterases at nerve-endings in tissues and organs. Histochemical investigations of tissular cholinesterases outside the nervous system, such as in smooth muscle fibers, are also presented. This book will be of value to physiologists, enzyme scientists and researchers, cell biologists, and histochemists.
