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Author: Haya Lorberboum-Galski
Publisher: CRC Press
ISBN: 0203216474
Category : Medical
Languages : en
Pages : 288
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Book Description
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati
Author: Haya Lorberboum-Galski
Publisher: CRC Press
ISBN: 0203216474
Category : Medical
Languages : en
Pages : 288
Get Book
Book Description
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati
Author: Arthur Frankel
Publisher: CRC Press
ISBN: 1000147797
Category : Science
Languages : en
Pages : 516
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Book Description
Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.
Author: John Middlebrook
Publisher: Elsevier
ISBN: 0323141331
Category : Science
Languages : en
Pages : 389
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Book Description
Receptor-Mediated Binding and Internalization of Toxins and Hormones presents the proceedings of a conference conducted for the purpose of exploring relationships between hormones and toxins, specifically, receptor-mediated internalization of toxins and hormones and the role of this internalization in message transmission and biodegradatory processes. This book is divided into three sections, with the first focusing on model systems of internalization. It presents pictorial illustrations of the receptor-mediated endocytosis of low-density lipoprotein via coated regions of membrane and discusses the receptor for lysosomal enzymes on the surface of cultured fibroblasts. The second section focuses on toxins and hormones and discusses such topics as receptor-mediated internalization of diphtheria toxin, diphtheria toxin interactions with an inhibitory activity from plasma membranes, and uptake mechanisms for ADP-ribosylating toxins. The third and final section focuses on hybrids and discusses such topics as chimeric toxins containing fragment A from diphtheria toxin, directed entry of hybrid proteins into cells via alternate receptors, and a hybrid protein of monoclonal anti-THY 1.2 and diphtheria toxin fragment A. This book will be of interest to practitioners in the fields of endocrinology, cell biology, and molecular genetics.
Author: Klaus Aktories
Publisher: John Wiley & Sons
ISBN: 3527614605
Category : Science
Languages : en
Pages : 334
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Book Description
This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.
Author:
Publisher: ScholarlyEditions
ISBN: 1481685481
Category : Medical
Languages : en
Pages : 248
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Book Description
Bacterial Toxins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Botulinum Toxins. The editors have built Bacterial Toxins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Botulinum Toxins in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bacterial Toxins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 1483284883
Category : Science
Languages : en
Pages : 442
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Book Description
The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Convenient benchtop format Methods presented for easy adaptation to new systems A virtual "A-B-C" of commonly used and available toxins Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins
Author: Teresa Krakauer
Publisher: MDPI
ISBN: 3038421634
Category : Electronic book
Languages : en
Pages : 307
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Book Description
This book is a printed edition of the Special Issue "Enterotoxins: Microbial Proteins and Host Cell Dysregulation" that was published in Toxins
Author: G.C. Satpathy
Publisher: Gyan Publishing House
ISBN: 9788178351681
Category : Biological weapons
Languages : en
Pages : 324
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Book Description
Biological weapons and relative terrorism is a challenge to the whole world. The book is a milestone on the subject and is a timely publication. The theme has deep thrust on anthrax scare after 11 September. It calls for urgent steps to sensitize the society to the dangers of bio-terrorism. This work is an authentic work on the subject. This is a book for all to study and be conscious and aware of the bio-technology war.
Author: Yehuda Gutman
Publisher: CRC Press
ISBN: 9789057020780
Category : Science
Languages : en
Pages : 520
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Book Description
Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.
Author: Rino Rappuoli
Publisher: OUP Oxford
ISBN: 019154728X
Category : Medical
Languages : en
Pages : 278
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Book Description
Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.
