Characterization of Polyethylene Glycol Hydrogels for Biomedical Applications PDF Download
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Author: Anushree Datta
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Anushree Datta
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 284
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Author: Kevin Worrell
Publisher:
ISBN:
Category : Colloids
Languages : en
Pages :
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Book Description
Biodegradable hydrogels have become very promising materials for a number of biomedical applications, including tissue engineering and drug delivery. For optimal tissue engineering design, the mechanical properties of hydrogels should match those of native tissues as closely as possible because these properties are known to affect the behavior and function of cells seeded in the hydrogels. At the same time, high water-contents, large mesh sizes and well-tuned degradation rates are favorable for the controlled release of growth factors and for adequate transport of nutrients through the hydrogel during tissue regeneration. With these factors in mind, the goal of this research was to develop and investigate the behavior of injectable, biodegradable hydrogels with enhanced stiffness properties that persist even at high degrees of swelling. In order to do this, degradable functionalities were incorporated into photo-crosslinkable poly(ethylene glycol) and poly(acrylic acid) hydrogels, and these two components were used to make a series of double-network hydrogels. Synthesis of the precursor macromers, photopolymerization of the hydrogels, and structural parameters of the hydrogels were analyzed. The composition and the molecular weight between crosslinks (Mc) of the hydrogel components were varied, and the degradation, swelling, thermal and mechanical properties of the hydrogels were characterized over various time scales. These properties were compared to corresponding properties of the component single-network hydrogels.
Author: Emily Rose Aurand
Publisher:
ISBN:
Category :
Languages : en
Pages : 172
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Neural tissue engineering through the use of biomaterials holds great promise for treating a wide variety of neurological disorders. The customizable nature of hydrogels provides the opportunity to mimic the brain's unique extracellular matrix (ECM). Hydrogels can be used to recreate this ECM environment to support neural cells in vitro, through 3D culturing, or during transplantation procedures. To be effective, hydrogels must be characterized chemically, physically, and mechanically, and the biocompatibility of these materials with neural cells and brain tissue must be defined. Twenty-five hydrogels were created from ratios of hyaluronic acid (HA) and poly(ethylene glycol) (PEG). Hydrogels were assessed for the properties of polymerization, degradation, and compressive modulus, and the cytocompatibility with encapsulated neural progenitor cells (NPC) from fetal and adult sources. The physical and mechanical properties of the hydrogels were found to be dependent on the polymer concentration. Additionally, the compressive moduli of the hydrogels were comparable to rodent brain tissue, indicating that the hydrogel formulations developed were physiologically relevant. Subsequently, NPC derived from fetal and adult rats (fNPC and aNPC, respectively) were encapsulated within the hydrogels. Twenty-four hour cell survival was highest at lower concentrations of HA and PEG. Three-week fNPC and aNPC differentiation was demonstrated to be influenced by mechanical properties. Fetal-NPC generally produced greater numbers of astrocytes in stiffer hydrogels, while increased numbers of neurons were observed in softer hydrogels. Greater numbers of aNPC became neuronal, regardless of stiffness. When two chosen hydrogels were used to implant NPC into the brain, the results suggested that encapsulated NPC survived at up to 50% two months post-implantation, indicating good cytocompatibility. Further, the implanted cells were able to migrate from the hydrogel into the surrounding brain tissue farther than unencapsulated cells. Immunolabeling for glial cells demonstrated that the hydrogels elicited a similar immune response as control treatments, establishing the histocompatibility with brain tissue. Based on these studies, HA-PEG hydrogels were biocompatible and could be used therapeutically in the brain. Further modifications and specializations of these hydrogels, such as the inclusion of growth factors or attachment factors, may provide specific therapeutic support for encapsulated cells and/or neurodegenerative disorders.
Author: Pietro Matricardi
Publisher: CRC Press
ISBN: 9814613622
Category : Medical
Languages : en
Pages : 527
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Book Description
Hydrogels are an emerging area of interest in medicine as well as pharmaceutics, and their physico-chemical characterization is fundamental to their practical applications. Compared with synthetic polymers, polysaccharides that are widely present in living organisms and come from renewable sources are extremely advantageous for hydrogel formation.
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Category :
Languages : en
Pages :
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Poly(ethylene glycol) (PEG) hydrogels containing tertiary amines were synthesized by thermally-initiated free-radical copolymerization of poly(ethylene glycol) methacrylate (PEGMA), poly(ethylene glycol) dimethacrylate (PEGDMA), and 2-dimethylaminoethyl methacrylate (DMAEMA). The mass fraction of each monomer was varied from 0 to ~1 to determine the composition for optimum mechanical properties and maximum tertiary amine content. Dry films were characterized by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), elemental analysis, dynamical mechanical analysis (DMA), tensile testing, swelling, and differential scanning calorimetry (DSC). The film composition with highest strength, elasticity, swelling, and amine content was found to be 30 wt% PEGDMA due to limited polymerization of DMAEMA with PEGDMA. Films composed of 10 wt% PEGDMA were subsequently quaternized with alkyl bromides of varying chain length (C8, C12, and C16) to impart antibacterial properties to the network. Quaternized films were characterized by elemental analysis, swelling, DSC, and a surface antimicrobial assay. The minimum quaternized DMAEMA concentration for antimicrobial activity was 22 wt% quaternized with C8Br and 30 wt% quaternized with C12Br and C16Br. The most potent alkyl bromide was C8Br followed by C12Br and C16Br. These quaternized PEG-co-poly(DMAEMA) hydrogels show promise as antibacterial materials for biomedical applications.
Author: Raphael M. Ottenbrite
Publisher: Springer Science & Business Media
ISBN: 144195919X
Category : Technology & Engineering
Languages : en
Pages : 438
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Book Description
Hydrogels are networks of polymer chains which can produce a colloidal gel containing over 99 per cent water. The superabsorbency and permeability of naturally occurring and synthetic hydrogels give this class of materials an amazing array of uses. These uses range from wound dressings and skin grafts to oxygen-permeable contact lenses to biodegradable delivery systems for drugs or pesticides and scaffolds for tissue engineering and regenerative medicine. Biomedical Applications of Hydrogels Handbook provides a comprehensive description of this diverse class of materials, covering both synthesis and properties and a broad range of research and commercial applications. The Handbook is divided into four sections: Stimuli-Sensitive Hydrogels, Hydrogels for Drug Delivery, Hydrogels for Tissue Engineering, and Hydrogels with Unique Properties. Key Features: Provides comprehensive coverage of the basic science and applications of a diverse class of materials Includes both naturally occurring and synthetic hydrogels Edited and written by world leaders in the field.
Author:
Publisher: ScholarlyEditions
ISBN: 1464994633
Category : Science
Languages : en
Pages : 342
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Book Description
Polyethylene Glycols—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Polyethylene Glycols. The editors have built Polyethylene Glycols—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polyethylene Glycols in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polyethylene Glycols—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Sutapa Biswas Majee
Publisher: BoD – Books on Demand
ISBN: 9535125095
Category : Science
Languages : en
Pages : 268
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Book Description
This book is an Up-to-date and authoritative account on physicochemical principles, pharmaceutical and biomedical applications of hydrogels. It consists of eight contributions from different authors highlighting properties and synthesis of hydrogels, their characterization by various instrumental methods of analysis, comprehensive review on stimuli-responsive hydrogels and their diverse applications, and a special section on self-healing hydrogels. Thus, this book will equip academia and industry with adequate basic and applied principles related to hydrogels.
Author: J. Milton Harris
Publisher: Springer Science & Business Media
ISBN: 1489907033
Category : Medical
Languages : en
Pages : 395
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Book Description
The idea for this book came from discussions among participants in a symposium on biotechnical applications at the "Pacifichem 89" meeting in Honolulu. It was the majority opinion of this group that a volume dedicated to biotechnical and biomedical applications of PEG chemistry would enhance research and development in this area. Though the book was conceived at the Honolulu meeting, it is not a proceedings of this symposium. Several groups who did not participate in this meeting are repre sented in the book, and the book incorporates much work done after the meeting. The book does not include contributions in all related areas to which PEG chemistry has been applied. Several invited researchers declined to parti.:ipate, and there is not enough space in this single volume to properly cover all submissions. Chapter I-an overview of the topic-discusses in brief applications not given detailed coverage in specifically devoted chapters. The following topics are covered: introduction to and fundamental properties of PEG and derivatives in Chapters 1-3; separations using aqueous polymer two-phase partitioning in Chapters 4-6; PEG-proteins as catalysts in biotechnical applications in Chapters 7 and 8; biomedical applications of PEG-proteins in Chapters 9-13; PEG modified surfaces for a variety of biomedical and biotechnical applications in Chapters 14-20; and synthesis of new PEG derivatives in Chapters 21 and 22.
