Author: James N. C. Kew
Publisher:
ISBN: 0199296758
Category : Medical
Languages : en
Pages : 586
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Book Description
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Author: Scott Kelby
Publisher: Peachpit Press
ISBN: 0321269063
Category : Computers
Languages : en
Pages : 200
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Book Description
"Author Scott Kelby (Editor-in-Chief of Photoshop User magazine) shows you how to unlock the power of Photoshop's channels and really start using Photoshop like a pro. But this isn't just a book of theory and technical jargon, this is a step-by-step, project-based book that will teach you exactly how to start using channels in your everyday work."--BOOK JACKET.
Author: Veit Flockerzi
Publisher: Springer Science & Business Media
ISBN: 3540348913
Category : Medical
Languages : en
Pages : 610
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Book Description
This volume provides up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression.
Author: Gildas Loussouarn
Publisher: Frontiers E-books
ISBN: 288919115X
Category :
Languages : en
Pages : 211
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Book Description
Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.
Author: Stephan Frings
Publisher: John Wiley & Sons
ISBN: 3527604979
Category : Science
Languages : en
Pages : 321
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Book Description
This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.
Author: Giovanni Maciocia
Publisher: Elsevier Health Sciences
ISBN: 0702032654
Category : Medical
Languages : en
Pages : 1967
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Book Description
One of the most highly-regarded and respected authors and lecturers in the West, Giovanni Maciocia, illuminates and examines the art of traditional Chinese acupuncture with this in-depth look at the secondary channels and other key structures encompassing the human body in Chinese anatomy. This book describes in detail the pathways, pathology, diagnosis, and treatment of the Luo, Muscle, and Divergent secondary channels, as well as other key structures such as the Cou Li and Huang membranes, and gives a thorough, clear overview of subjects poorly understood and incompletely covered in other English language texts. Over one third of the book is dedicated to the Eight Extraordinary Channels, providing the reader with the most in-depth information available in the English language. Drawing on his broad clinical experience, the author covers the energetic physiology, pathology and points by body area, providing ease of access for both the student and practitioner of acupuncture. The Channels of Acupuncture presents comprehensive and clear information on an essential part of traditional Chinese medicine. - Covers key channels not thoroughly discussed in other texts, giving all students and practitioners detailed and clear material to guide them in their practice of acupuncture. - Offers new information and insight on other key body structures in Chinese medicine including extraordinary vessels as well as the Cou Li and Huang membranes. - Clear illustrations depict the exact channel pathways, diminishing any confusion about their location. - Case histories and research from Giovanni Maciocia present a wide range of experiences and examples of clinical practice and study.
Author: Daniel Levin Becker
Publisher: Harvard University Press
ISBN: 0674065271
Category : History
Languages : en
Pages : 351
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Book Description
Main description: What sort of society could bind together Jacques Roubaud, Italo Calvino, Marcel Duchamp, and Raymond Queneau-and Daniel Levin Becker, a young American obsessed with language play? Only the Oulipo, the Paris-based experimental collective founded in 1960 and fated to become one of literature's quirkiest movements. An international organization of writers, artists, and scientists who embrace formal and procedural constraints to achieve literature's possibilities, the Oulipo (the French acronym stands for 0workshop for potential literature0) is perhaps best known as the cradle of Georges Perec's novel A Void, which does not contain the letter e. Drawn to the Oulipo's mystique, Levin Becker secured a Fulbright grant to study the organization and traveled to Paris. He was eventually offered membership, becoming only the second American to be admitted to the group. From the perspective of a young initiate, the Oulipians and their projects are at once bizarre and utterly compelling. Levin Becker's love for games, puzzles, and language play is infectious, calling to mind Elif Batuman's delight in Russian literature in The Possessed. In recent years, the Oulipo has inspired the creation of numerous other collectives: the OuMuPo (a collective of DJs), the OuMaPo (marionette players), the OuBaPo (comic strip artists), the OuFlarfPo (poets who generate poetry with the aid of search engines), and a menagerie of other Ou-X-Pos (workshops for potential something). Levin Becker discusses these and other intriguing developments in this history and personal appreciation of an iconic-and iconoclastic-group.
Author:
Publisher:
ISBN:
Category : River channels
Languages : en
Pages : 108
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Book Description
Author: Stephen Romaniello
Publisher: John Wiley & Sons
ISBN: 0470102640
Category : Computers
Languages : en
Pages : 546
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Book Description
"Photoshop channels and masks are complex and powerful tools that give designers tremendous control over color and make it easy to create composite images. This title aims to untangle the complexities of channels and masks, and shows Photoshop users how to use them like the pros do, offering real-world examples"--Publisher's description.
Author: Miki Shima
Publisher: Blue Poppy Enterprises, Inc.
ISBN: 9781891845154
Category : Medical
Languages : en
Pages : 300
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Book Description
