Challenges in Analytical Quality Assurance

Challenges in Analytical Quality Assurance PDF Author: Manfred Reichenbächer
Publisher: Springer Science & Business Media
ISBN: 3642165958
Category : Science
Languages : en
Pages : 371

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Book Description
Working in the lab, but unsure what your results actually mean? Would you like to know how to apply trueness tests, calculate standard deviations, estimate measurement uncertainties or test for linearity? This book offers you a problem-based approach to analytical quality assurance (AQA). After a short introduction into required fundamentals, various topics such as statistical tests, linear regression and calibration, tool qualification or method validation are presented in the form of exercises for self-study. Solutions are provided in a clear step-by-step manner. Interactive Excel-sheets are available as Extra Materials for trying out the various concepts. For professionals as well as graduate students confronted with analytical quality assurance for the first time, this book will be the clue to meeting such challenges.

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory PDF Author: Hari Nair
Publisher: Academic Press
ISBN: 0128009926
Category : Science
Languages : en
Pages : 306

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Book Description
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Essentials of Nucleic Acid Analysis

Essentials of Nucleic Acid Analysis PDF Author: Jacquie T Keer
Publisher: Royal Society of Chemistry
ISBN: 1847558216
Category : Science
Languages : en
Pages : 273

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Book Description
Over the last decade there has been a rapid development of molecular techniques, with an increasing range of instrumentation now available. The development of accompanying reference literature has not kept pace with technological advances and this poses significant challenges to the analyst. Essentials of Nucleic Acid Analysis sets out to guide the analyst through the steps needed to obtain good quality results in DNA analysis. The underlying principles for achieving this goal were formulated by LGC (formerly the Laboratory of the Government Chemist) as the six principles for ensuring valid analytical measurement, which are detailed in the introduction. The reader is also provided with guidelines for method validation and quality control of established and emerging DNA measurement techniques. The authors of each chapter are practitioners of the art of DNA analysis in areas where the quality of the result is critical. Technical details and examples of application of key techniques in nucleic acid analysis are provided while highlighting best practice, available standards and practical advice on improving measurement quality. This book provides an indispensable handbook and premier reference for those working in the widely varying areas and specifically in the fields of food analysis and forensic applications.

Food Fraud

Food Fraud PDF Author: Rosalee S. Hellberg
Publisher: Academic Press
ISBN: 0128172436
Category : Medical
Languages : en
Pages : 415

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Book Description
Food Fraud: A Global Threat With Public Health and Economic Consequences serves as a practical resource on the topic of food fraud prevention and compliance with regulatory and industry standards. It includes a brief overview of the history of food fraud, current challenges, and vulnerabilities faced by the food industry, and requirements for compliance with regulatory and industry standards on mitigating vulnerability to food fraud, with a focus on the Global Food Safety Initiative (GFSI) Benchmarking Requirements. The book also provides individual chapters dedicated to specific commodities or sectors of the food industry known to be affected by fraud, with a focus on specific vulnerabilities to fraud, the main types of fraud committed, analytical methods for detection, and strategies for mitigation. The book provides an overview of food fraud mitigation strategies applicable to the food industry and guidance on how to start the process of mitigating the vulnerability to food fraud. The intended audience for this book includes food industry members, food safety and quality assurance practitioners, food science researchers and professors, students, and members of regulatory agencies. - Presents industry and regulatory standards for mitigating vulnerability to food fraud including Global Food Safety Initiative (GFSI) Benchmarking Requirements - Provides tools and resources to comply with industry and regulatory standards, including steps for developing a food fraud vulnerability assessment and mitigation plan - Contains detailed, commodity-specific information on the major targets of food fraud, including specific vulnerabilities to fraud, analytical methods, and strategies for mitigation

Registries for Evaluating Patient Outcomes

Registries for Evaluating Patient Outcomes PDF Author: Agency for Healthcare Research and Quality/AHRQ
Publisher: Government Printing Office
ISBN: 1587634333
Category : Medical
Languages : en
Pages : 385

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Book Description
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Encyclopedia of Mathematical Geosciences

Encyclopedia of Mathematical Geosciences PDF Author: B. S. Daya Sagar
Publisher: Springer Nature
ISBN: 3030850404
Category : Science
Languages : en
Pages : 1744

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Book Description
The Encyclopedia of Mathematical Geosciences is a complete and authoritative reference work. It provides concise explanation on each term that is related to Mathematical Geosciences. Over 300 international scientists, each expert in their specialties, have written around 350 separate articles on different topics of mathematical geosciences including contributions on Artificial Intelligence, Big Data, Compositional Data Analysis, Geomathematics, Geostatistics, Geographical Information Science, Mathematical Morphology, Mathematical Petrology, Multifractals, Multiple Point Statistics, Spatial Data Science, Spatial Statistics, and Stochastic Process Modeling. Each topic incorporates cross-referencing to related articles, and also has its own reference list to lead the reader to essential articles within the published literature. The entries are arranged alphabetically, for easy access, and the subject and author indices are comprehensive and extensive.

Environmental Chemistry: Key Concepts

Environmental Chemistry: Key Concepts PDF Author: cybellim Ltd
Publisher: YouGuide Ltd
ISBN: 1836795173
Category :
Languages : en
Pages : 227

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Book Description
Designed for professionals, students, and enthusiasts alike, our comprehensive books empower you to stay ahead in a rapidly evolving digital world. * Expert Insights: Our books provide deep, actionable insights that bridge the gap between theory and practical application. * Up-to-Date Content: Stay current with the latest advancements, trends, and best practices in IT, Al, Cybersecurity, Business, Economics and Science. Each guide is regularly updated to reflect the newest developments and challenges. * Comprehensive Coverage: Whether you're a beginner or an advanced learner, Cybellium books cover a wide range of topics, from foundational principles to specialized knowledge, tailored to your level of expertise. Become part of a global network of learners and professionals who trust Cybellium to guide their educational journey. www.cybellium.com

Feature Interactions in Software and Communication Systems IX

Feature Interactions in Software and Communication Systems IX PDF Author: Lydie Du Bousquet
Publisher: IOS Press
ISBN: 1586038451
Category : Computers
Languages : en
Pages : 232

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Book Description
Deals with the feature interaction problem in telecommunication systems.

Organic Metal and Metalloid Species in the Environment

Organic Metal and Metalloid Species in the Environment PDF Author: Alfred V. Hirner
Publisher: Springer Science & Business Media
ISBN: 3662091356
Category : Science
Languages : en
Pages : 360

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Book Description
This book presents contributions by experts from diverse disciplines, estimating the global levels of biogeogenic and anthropogenic emissions of organometal(loid) compounds, and thus presenting insight into processes which influence the genesis, as well as the distribution and stability of these species and their interaction with each other and other matrix compounds. The authors evaluate identify potential "hot spots" of organometal(loid)s, which can negatively influence ecosystems and human health.

Mastering Analytical Chemistry

Mastering Analytical Chemistry PDF Author:
Publisher: Cybellium
ISBN: 1836790554
Category : Science
Languages : en
Pages : 225

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Book Description
Welcome to the forefront of knowledge with Cybellium, your trusted partner in mastering the cutting-edge fields of IT, Artificial Intelligence, Cyber Security, Business, Economics and Science. Designed for professionals, students, and enthusiasts alike, our comprehensive books empower you to stay ahead in a rapidly evolving digital world. * Expert Insights: Our books provide deep, actionable insights that bridge the gap between theory and practical application. * Up-to-Date Content: Stay current with the latest advancements, trends, and best practices in IT, Al, Cybersecurity, Business, Economics and Science. Each guide is regularly updated to reflect the newest developments and challenges. * Comprehensive Coverage: Whether you're a beginner or an advanced learner, Cybellium books cover a wide range of topics, from foundational principles to specialized knowledge, tailored to your level of expertise. Become part of a global network of learners and professionals who trust Cybellium to guide their educational journey. www.cybellium.com