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Author: Frank Entschladen
Publisher: Karger Medical and Scientific Publishers
ISBN: 380559321X
Category : Science
Languages : en
Pages : 185
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Book Description
Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
Author: Ivana Pajic-Lijakovic
Publisher: Academic Press
ISBN: 0128203110
Category : Technology & Engineering
Languages : en
Pages : 316
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Book Description
Viscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multiscale constitutive modeling and how to measure these rheological parameters based on existent micro-devices such as micro-rheology and micro-elastography. The book sheds light on inter-relationships across viscoelasticity scales, an essential step for understanding various biomedical processes such as morphogenesis, wound healing and cancers invasion. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelasticity at a supracellular level are also covered, providing valuable insights for biologists, physicists, engineers, students and researchers in the field of developmental biology. As this is a complex multidisciplinary field, perspectives are included from experts in biology, biochemistry, biomedicine, biophysics and biorheology. Readers will gain a deeper understanding of the complex dynamics that represent challenges and the necessity for further development in the field. Discusses the biological/biochemical mechanisms of collective cell migration Covers the inter-relation between collective cell migration and viscoelasticity by proposing rheological parameters Contains critical consideration of various experimental techniques that are suitable to measure these parameters
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Frank Entschladen
Publisher: Karger Medical and Scientific Publishers
ISBN: 380559321X
Category : Science
Languages : en
Pages : 185
Get Book Here
Book Description
Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
Author: Alexis Gautreau
Publisher: Springer Nature
ISBN: 1493977016
Category : Science
Languages : en
Pages : 402
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Book Description
This volume covers various assays and techniques that have been developed to study and characterize the cell migration in vitro, ex vivo, and in vivo. The chapters in this book present readers with the latest protocols to observe, quantify, and control cell migration. Some of the topics explored in this book are: migration in confined environments, microfluidic devices, optogenetics, chemotaxis, electrotaxis, detection of migrasomes, migration of Q cells in Caenorhabditis elegans, of Drosophila macrophages, optogenetics of cell migration, intravital imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and comprehensive, Cell Migration: Methods and Protocols is a valuable resource for anyone interested in learning more about this expanding field.
Author:
Publisher: Academic Press
ISBN: 0123973473
Category : Science
Languages : en
Pages : 1081
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Book Description
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Author: Doris Wedlich
Publisher: John Wiley & Sons
ISBN: 3527604073
Category : Science
Languages : en
Pages : 398
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Book Description
Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.
Author: Cheng Dong
Publisher: Springer
ISBN: 3319952943
Category : Medical
Languages : en
Pages : 378
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Book Description
This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
Author: Jun-Lin Guan
Publisher: Springer Science & Business Media
ISBN: 1592598609
Category : Science
Languages : en
Pages : 359
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Book Description
A collection of classic, novel, and state-of-the-art methods for the study of cell migration in cultured cells, different model organisms, and specialized cells in normal development and disease. Highlights include basic assays that apply to all cell migration studies in vitro, assays in various model organisms, and assays for cancer cells, endothelial cells, and neurons both in vitro and in animal models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Author: Ajaykumar Vishwakarma
Publisher: Academic Press
ISBN: 0128027568
Category : Science
Languages : en
Pages : 644
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Book Description
Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points
Author: Caterina A. M. La Porta
Publisher: Springer Nature
ISBN: 3030175936
Category : Science
Languages : en
Pages : 135
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Book Description
Cell migration plays an important role during development and in many physiological and pathological processes, from wound healing to cancer. This edited volume presents a collection of contributions meant to illustrate the state of the art on this topic from an interdisciplinary perspective. Readers will find a detailed discussion of the properties of individual and collective cell migration, including the associated biochemical regulation and important biophysical and biomechanical aspects. The book includes information on the latest experimental techniques employed to study cell migration, from microfluidics to traction force microscopy, as well as the latest theoretical and computational models used to interpret the experimental data. Finally, the role of cell migration in cancer and in development is also reviewed. The contents of this work should appeal to students and researchers in biology and biophysics who want to get up to date on the latest interdisciplinary development in this broad field of research. The chapters are written in a self-contained form and can also be used as individual articles.
