Cell Mediated Immune Response to Influenza Virus Infection PDF Download
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Author: Nai Ki Mak
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 456
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Book Description
Author: Nai Ki Mak
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 456
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Robert G. Webster
Publisher: John Wiley & Sons
ISBN: 111863683X
Category : Medical
Languages : en
Pages : 684
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Book Description
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.
Author: Jiri Mestecky
Publisher: Springer Science & Business Media
ISBN: 3642745296
Category : Medical
Languages : en
Pages : 229
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Book Description
Oral immunization has a fascinating and frequently successful history, yet it has been largely overshadowed by other immunization methods. Various vaccines that lead to the induction of antibodies in respiratory, gastrointestinal, and genitourinary tracts are currently under development, and others are in use for the immunization of animals as well as humans. This volume gives oral immunization the attention it deserves in light of recent methodological and technical advances in antigen delivery systems.
Author: D. Brian Thomas
Publisher: CRC Press
ISBN: 9780824790530
Category : Medical
Languages : en
Pages : 548
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Book Description
Presents a comprehensive review of cell-mediated immunity to viral infection, highlighting aspects relevant to HIV research. Opening chapters discuss antigen processing and presentation, and lymphokine function. Subsequent chapters consider immune responses to individual viruses including: HIV, visn
Author: Anthony Thomas DiPiazza
Publisher:
ISBN:
Category :
Languages : en
Pages : 290
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Book Description
Influenza A viruses continue to pose a threat to human health worldwide and virusspecific CD4 T cells are key to protective immunity. The goal of the experiments within this thesis was to provide novel insight into elements within CD4 T cell responses that influence CD4 T cell specificity and function. Using a combination of novel reporter viruses, intravascular labeling in vivo, multi-parameter flow cytometry, and cytokine ELISpot procedures in two mammalian models, this work examined various stages of the developing immune response and the relationship between antigen acquisition, CD4 T cell fate choice, trafficking and compartmentalization within the inflamed lung, antigen specificity, and cytokine functionality. We found that pandemic 2009 H1N1 virus infection resulted in a broad pattern of viral antigen acquisition in the lung. Complex subpopulations of MHC class II-positive cells from both the hematopoietic and non-hematopoietic lineages were identified, with dynamic shifts over time. Our results demonstrated that antigen access occurs by uptake of exogenous antigen as well as infection. Finally, our results confirmed that many different cell types displayed peptide:MHC class II complexes in situ and possessed the capacity to stimulate influenza-specific CD4 T cells. These results correlated with differences in infection status, cell lineage, and MHC class II expression. These data suggest that there are many different types of antigen presenting cells in the lung that may impose additional checkpoints of CD4 T cell functionality and regulation. At the peak of the immune response, we found that lung CD4 T cells compartmentalized to vasculature and tissue. Antigen-experienced CD4 T cells were enriched in the tissue and expressed higher levels of molecules involved in trafficking to sites of pulmonary infection, damage, and repair. Surprisingly, we found similar representation in the fine specificity, immunodominance hierarchy, and polyfunctional potential of effector CD4 T cells in the two compartments. These results suggest that imprinting of CD4 effector programs in the priming lymph node plays a strong deterministic influence on CD4 function and fate. Also, we provide evidence of cellular intermediates in CD4 T cell trafficking in the lung. Finally, this thesis includes the first description of the CD4 and CD8 T cell repertoires in response to infection, a key step needed to advance the ferret model forward for future transmission and vaccine studies. Mechanistic studies of infection and vaccination in domestic ferrets may reveal novel links between antigen specificity and effector function, cellular correlates of protection, and the merits, consequences, and cellular heterogeneity of complex immunological memory.
Author: Morris Pollard
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 322
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Book Description
Author: B.A. Askonas
Publisher: Springer Science & Business Media
ISBN: 1468457128
Category : Medical
Languages : en
Pages : 298
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Book Description
Virus diseases continue to represent serious health problems in most parts of the world. In spite of the fact that diseases such as polio myelitis and measles have been controlled in the industrialized countries by vaccination, vaccines now in use in tropical countries have proved not to be optimal. Further research is needed to develop new vaccines that will be effective in all countries. To do so we need to understand better the immune response to different viruses so that we may be able to maxi mize the protective response of new vaccines and minimize their potential immunopathologic effect. An exciting new discovery which is now being further developed is the possibility of being able to use some viruses (e.g. vaccinia, adenoviruses, etc.), as carriers for other antigens. This may open up the way for the production of vaccines that will be inexpensive and that will confer long lasting immunity after only one injection. This meeting has also served to review our present knowledge of virus diseases which are still of great importance such as hepatitis, dengue and influenza.
Author: Mody Toure
Publisher:
ISBN:
Category :
Languages : en
Pages : 108
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Book Description
Author: David E. Swayne
Publisher: John Wiley & Sons
ISBN: 1118924339
Category : Medical
Languages : en
Pages : 755
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Book Description
Animal Influenza, Second Edition is a comprehensive text on animal influenza. Organized by species, coverage includes avian, swine, equine and mammals, with each section including data on influenza viruses, the infection and disease they cause, and strategies used in control. Covers the full range of topics within avian, swine, equine and mammalian influenzas in one comprehensive and authoritative text Provides a summarization of peer-reviewed and empirical data on influenza viruses, the infection, and diseases they cause Discusses strategies used in control of the disease Leading experts are drawn together to provide an international and multi-disciplinary perspective Fuses latest developments in basic scientific research with practical guidance on management of the disease
