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Author: Horst Robenek
Publisher: CRC Press
ISBN: 9780849355059
Category : Medical
Languages : en
Pages : 342
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Book Description
Cell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.
Author: Horst Robenek
Publisher: CRC Press
ISBN: 9780849355059
Category : Medical
Languages : en
Pages : 342
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Book Description
Cell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.
Author: Lena Jonasson
Publisher:
ISBN: 9789179002343
Category :
Languages : en
Pages : 64
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Book Description
Author: Sergey Fedoroff
Publisher: Springer Science & Business Media
ISBN: 1461537541
Category : Science
Languages : en
Pages : 272
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Book Description
This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.
Author: R. T. Dean
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 446
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Book Description
This book provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes, macrophages, growth factors, cytokines, and oxysterols to atherogenesis are all discussed, as are the roles of smooth muscle and endothelial cells. A summary of the current methods of diagnosis and the future prospect of using biochemical markers from plasma is also discussed. There is a critical look at gene therapy and other future therapeutic strategies based on the molecular and cellular causes of atherosclerosis. Each chapter is written by two or more authors from different laboratories to ensure a balanced approach. It will be invaluable to all biochemical researchers with a specialist or passing interest in atherosclerosis research. presents a critical look
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Peter C. Weber
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781700993
Category : Medical
Languages : en
Pages : 348
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Book Description
Author: Gotthard Schettler
Publisher: Springer Science & Business Media
ISBN: 3642831184
Category : Science
Languages : en
Pages : 176
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Book Description
The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.
Author: Alain Haziot
Publisher: Frontiers Media SA
ISBN: 2832539890
Category : Medical
Languages : en
Pages : 201
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Book Description
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune responses. Blood elements (such as leukocytes, platelets, and vesicles) converge to the barrier formed by the endothelium where perivascular (such as macrophages, pericytes) initiate, convey, and/or amplify signals revealing tissue status. The innate and adaptative functions of endothelial cells themselves together with the immune functions of assembled cells at a focal point in capillaries create the potential for exchange of signals and dynamic fine tuning of responses through cell programming and cell selection. The resulting immune response may range from inadequate immunity and/or exhaustion to excess tissue destruction and fibrosis. Productive inflammation and its resolution are critically reliant on which cells are recruited and in which order, their state of activation, and interactions between recruited cells. Tissue-dependent signals further shape the recruitment of leukocytes to the endothelium. In the kidney for instance, in the presence of immune complexes, perivascular resident macrophages located in subendothelial spaces coupled with endothelial cells induce monocyte and neutrophil tissue infiltration, operating therefore as an anatomical and functional unit. The goals of this Research Topic are (i) to analyze how signal integration and partnering of cell types in transendothelial migration contribute to the development of tissue inflammation and how responses are geared towards specific profiles of reactions to injury; (ii) how the interplay between cell types including, but not limited to, endothelial cells, monocytes, resident macrophages, and T and B cells dynamically governs the immune responses that take place in the tissue; (iii) in which way do integrative capacities of endothelial and subendothelial cells shape and coordinate the successive recruitment of leukocyte populations.
Author: Georg Wick
Publisher: Springer Science & Business Media
ISBN: 370910338X
Category : Medical
Languages : en
Pages : 628
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Book Description
It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
Author: Jahnic Beck-Joseph
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Cardiovascular disease is the leading cause of death worldwide, with atherosclerosis being the largest contributor towards life-threatening events. Cellular activity and cholesterol accumulation lead to vascular remodeling and the formation of fatty plaques. Complications arise from blood clots forming at ruptured or eroded plaques leading to thrombotic occlusion. Vascular smooth muscle cells and macrophages switch their phenotypes during atherosclerosis and influence the disease in various ways. Knowledge about intercellular communication is critical to understanding the disease and the development of novel medications. In this thesis, the literature has been reviewed on molecular interactions between vascular smooth muscle cells and macrophages in atherosclerosis. Communication through soluble factors, extracellular vesicles, and physical contact are discussed. Additionally, preliminary in-vitro experiments were devised in an attempt to probe transcriptional changes occurring during early phenotypic switching. To mimic early lesions, primary mouse smooth muscle cells and macrophages were co-cultured with low-density lipoproteins. Muscle cells were kept pure using transwell inserts and analyzed using qPCR. Markers associated with early phenotypic switching from a contractile to a dysfunctional cell were monitored. In future studies, cells undergoing transitioning could be subjected to next-generation sequencing for in-depth transcriptional analysis and insights into pathways involved in early phenotypic switching.At this time, there is insufficient data to statistically validate findings. However, the preliminary qPCR data shows interesting results with contractile markers generally downregulated and macrophage markers upregulated. Synergistic effects were observed for some genes, for which differential expression was only achieved with culture conditions that included both LDL and macrophages"--
