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Author: Hiroyoshi Hidaka
Publisher: Elsevier
ISBN: 0323145736
Category : Medical
Languages : en
Pages : 569
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Book Description
Calmodulin Antagonists and Cellular Physiology focuses on the biochemistry of calmodulin antagonists as regulators of cellular physiology. Emphasis is placed on the use of calmodulin antagonists as an indicator of calmodulin function. The mechanism of action of calmodulin antagonists and their interactions with calmodulin are explored. This book is comprised of 33 chapters and begins with an introduction to the biochemical aspects of calmodulin as well as its distribution and functions, followed by a discussion on how calmodulin antagonists and other agents modulate Ca2+-dependent regulatory systems. The next section is devoted to the mechanism of action of calmodulin antagonists and includes chapters that examine the interaction of various drugs with calmodulin and the structure-activity relationships of calmodulin antagonists. The effects of calmodulin antagonists on cell proliferation and growth are then discussed. The remaining chapters deal with the role of calmodulin antagonists in cell function and the contractile process, along with their effect on protein kinase C. This monograph will be a useful resource for biochemists as well as students and researchers in biochemistry.
Author: Hiroyoshi Hidaka
Publisher: Elsevier
ISBN: 0323145736
Category : Medical
Languages : en
Pages : 569
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Book Description
Calmodulin Antagonists and Cellular Physiology focuses on the biochemistry of calmodulin antagonists as regulators of cellular physiology. Emphasis is placed on the use of calmodulin antagonists as an indicator of calmodulin function. The mechanism of action of calmodulin antagonists and their interactions with calmodulin are explored. This book is comprised of 33 chapters and begins with an introduction to the biochemical aspects of calmodulin as well as its distribution and functions, followed by a discussion on how calmodulin antagonists and other agents modulate Ca2+-dependent regulatory systems. The next section is devoted to the mechanism of action of calmodulin antagonists and includes chapters that examine the interaction of various drugs with calmodulin and the structure-activity relationships of calmodulin antagonists. The effects of calmodulin antagonists on cell proliferation and growth are then discussed. The remaining chapters deal with the role of calmodulin antagonists in cell function and the contractile process, along with their effect on protein kinase C. This monograph will be a useful resource for biochemists as well as students and researchers in biochemistry.
Author: D. Marme
Publisher: Springer Science & Business Media
ISBN: 3642700705
Category : Science
Languages : en
Pages : 398
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Book Description
The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
Author: Wai Yiu Cheung
Publisher: Academic Press
ISBN: 1483281981
Category : Science
Languages : en
Pages : 331
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Book Description
Calcium and Cell Function, Volume V emphasizes the roles of calcium in cellular functions. This book consists of eight chapters. Chapter 1 presents evidence for the role of calmodulin in cell proliferation. The role of calcium in the control of cyclic AMP metabolism in glial and pituitary tumor cells is analyzed in Chapter 2. Chapter 3 explains the evidence that calmodulin regulates neurotransmitter synthesis, while Chapter 4 deliberates the role of calcium in adipocytes. Chapter 5 is devoted to the modulatory function of lipomodulin in cellular phospholipid metabolism. The pharmacological properties of naphthalenesulfonamides as calmodulin antagonists, phophorylase kinase, and phospholipidsensitive calcium-dependent protein kinase are reviewed in the last chapters. This volume is valuable to biologists and medical practitioners interested in calcium and cell function.
Author: Anthony L. Gotter
Publisher:
ISBN:
Category :
Languages : en
Pages : 284
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Book Description
Author: Shiro Kakiuchi
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 496
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Book Description
Author: Charles Gerday
Publisher: Springer Science & Business Media
ISBN: 3642730426
Category : Science
Languages : en
Pages : 265
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Book Description
The idea of Professors Bolis and Gilles to gather together for a 3 days' meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium and calcium bind ing proteins seemed at first particularly attractive, and when they asked me to take charge of the scientific organization of the symposium, I accepted with enthusiasm. It rapidly became clear that the major problem would be the selection of the topics, since it was impossible to cover completely and in depth such a broad and dynamic area of research. In our view, one imperative was to associate as intimately as possible the structural and the functional aspects of the areas covered. Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. The presentations were made by leading investigators in their field. Some of them do not, however, appear in the present volume, for which there are two reasons: first, some of the contributions were somewhat outside the scope of the book; second, three speakers, for valid reasons, simply found no opportunity to write a manuscript in the allotted time.
Author: Hiroyoshi Hidako
Publisher:
ISBN:
Category :
Languages : en
Pages : 543
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Book Description
Author: A. J. Trewavas
Publisher: Springer
ISBN:
Category : Nature
Languages : en
Pages : 482
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Book Description
This volume summarises the lecture and poster sessions of a NATO advanced workshop held in Edinburgh, July 15th-19th, 1985. The workshop was held to bring together plant scientists of many different disciplines but who share a common interest in the regulatory role of calcium in plant development. Although this volume covers the formal proceedings, an equal length of time was devoted to discussion both in large and small groups. A little of the flavour of the directions and character of the discussions will be found in the final article by David Clarkson which was written to cover this other wise uncovered area of the workshop. The volume reflects much of the current excitement in the field of plant calcium research. Many of the participants are pioneers in their res pective areas and the extent to which the last five years has seen a drama tic unfolding, a complete inversion of the role of calcium from simple macro nutrient to major metabolic and developmental controller is recounted here. The material is new and much of it unpublished. In plant physiology, the eighties may yet be designated the decade of calcium.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1068
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Book Description
