Author: Michael Patrick Gibbens
Publisher:
ISBN: 9781580011051
Category : Barrier-free design
Languages : en
Pages : 457

Get Book Here

Book Description

Author: Jonathan Brotchie
Publisher: Academic Press
ISBN: 012381328X
Category : Medical
Languages : en
Pages : 661

Get Book Here

Book Description
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author: Gordon M. Shepherd
Publisher: Oxford University Press
ISBN: 0190636114
Category : Medical
Languages : en
Pages : 625

Get Book Here

Book Description
In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit

Author: Emmanuel Valjent
Publisher: Frontiers E-books
ISBN: 2889190706
Category :
Languages : en
Pages : 216

Get Book Here

Book Description
This Research Topic aims to highlight and cover recent understanding on striatal signaling pathways, which are activated by a variety of therapeutic agents or drugs of abuse in physiological and pathological context. The recent development of different mouse models allowing the identification of specific cell types and neuronal circuits in which a given signaling pathway is activated in various physiological and pathological conditions provides essential information and allowed to untangle the complexity of study signal transduction in the brain in vivo.

Author: Gordon Shepherd
Publisher: Oxford University Press
ISBN: 0199780331
Category : Medical
Languages : en
Pages : 535

Get Book Here

Book Description
Microcircuits are the specific arrangements of cells and their connections that carry out the operations unique to each brain region. This resource summarizes succinctly these circuits in over 40 regions - enabling comparisons of principles across both vertebrates and invertebrates. It provides a new foundation for understanding brain function that will be of interest to all neuroscientists. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.

Author: Harald Schulze
Publisher: Springer
ISBN: 3319395629
Category : Medical
Languages : en
Pages : 457

Get Book Here

Book Description
This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.​

Author: Klaus Ley
Publisher: Frontiers Media SA
ISBN: 2889194302
Category : Chemokines
Languages : en
Pages : 109

Get Book Here

Book Description
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.

Author:
Publisher:
ISBN:
Category : Government Publications
Languages : en
Pages : 410

Get Book Here

Book Description

Author: Gang Chen
Publisher: ArchiteG, Inc.
ISBN: 0984374140
Category : Architecture
Languages : en
Pages : 196

Get Book Here

Book Description
Learn the Tips, Become One of Those Who Know Building Construction and Architectural Practice, and Thrive! For architectural practice and building design and construction industry, there are two kinds of people: those who know, and those who don't. The tips of building design and construction and project management have been undercover-until now. Most of the existing books on building construction and architectural practice are too expensive, too complicated, and too long to be practical and helpful. This book simplifies the process to make it easier to understand and uncovers the tips of building design and construction and project management. It sets up a solid foundation and fundamental framework for this field. It covers every aspect of building construction and architectural practice in plain and concise language and introduces it to all people. Through practical case studies, it demonstrates the efficient and proper ways to handle various issues and problems in architectural practice and building design and construction industry. It is for ordinary people and aspiring young architects as well as seasoned professionals in the construction industry. For ordinary people, it uncovers the tips of building construction; for aspiring architects, it works as a construction industry survival guide and a guidebook to shorten the process in mastering architectural practice and climbing up the professional ladder; for seasoned architects, it has many checklists to refresh their memory. It is an indispensable reference book for ordinary people, architectural students, interns, drafters, designers, seasoned architects, engineers, construction administrators, superintendents, construction managers, contractors, and developers. You will learn: 1. How to develop your business and work with your client. 2. The entire process of building design and construction, including programming, entitlement, schematic design, design development, construction documents, bidding, and construction administration. 3. How to coordinate with governing agencies, including a county's health department and a city's planning, building, fire, public works departments, etc. 4. How to coordinate with your consultants, including soils, civil, structural, electrical, mechanical, plumbing engineers, landscape architects, etc. 5. How to create and use your own checklists to do quality control of your construction documents. 6. How to use various logs (i.e., RFI log, submittal log, field visit log, etc.) and lists (contact list, document control list, distribution list, etc.) to organize and simplify your work. 7. How to respond to RFI, issue CCDs, review change orders, submittals, etc. 8. How to make your architectural practice a profitable and successful business. About the author Gang Chen holds a master's degree from the School of Architecture, University of Southern California (USC), Los Angeles, and a bachelor's degree from the School of Architecture, South China University of Technology. He has over 20 years of professional experience. Many of the projects he was in charge of or participated in have been published extensively in Architecture, Architectural Record, The Los Angeles Times, The Orange County Register, etc. He has worked on a variety of unusual projects, including well-known, large-scale healthcare and hospitality projects with over one billion dollars in construction costs, award-winning school designs, highly-acclaimed urban design and streetscape projects, multifamily housing, high-end custom homes, and regional and neighborhood shopping centers. Gang Chen is a LEED AP and a licensed architect in California. He is also the internationally acclaimed author for other fascinating books, including Planting Design Illustrated and LEED Exam Guides Series, which include one guidebook for each of the LEED exams.

Author: Alfred Wittinghofer
Publisher: Springer
ISBN: 3709118069
Category : Science
Languages : en
Pages : 447

Get Book Here

Book Description
This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.