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Author: M.F. Crass, III
Publisher: CRC Press
ISBN: 9780849386619
Category : Medical
Languages : en
Pages : 344
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Book Description
This is the first book to exclusively address the actions of calcium-regulating hormones and peptides in the cardiovascular system. With 111 illustrations and 13 tables, this comprehensive volume includes: An extensive and critical review of present knowledge of the structure, synthesis, secretion, metabolism, receptors, signal transduction, and actions on classical target cells of each of the calcium-regulating hormones and peptides Discussions on parathyroid hormone and calcitonin, parathyroid hormone-related protein, parathyroid hypertensive factor, 1,25 dihydroxyvitamin D3, calcitonin gene-related peptide, and certain steroid hormones in terms of vascular biology and cardiac function The integrated physiology of calcium-regulating hormones in terms of blood pressure regulation in normotensive and hypertensive settings State-of-the-art electrophysiological techniques used by leading cardiovascular biologists to assess calciotropic hormone effects on calcium channel currents in both vascular smooth muscle and cardiac myocytes Studies on the regulation of hormone and receptor gene expression in the context of possible regulation of local and systemic blood flow and cardiac function by calcium-regulating hormones and peptides
Author: M.F. Crass, III
Publisher: CRC Press
ISBN: 9780849386619
Category : Medical
Languages : en
Pages : 344
Get Book
Book Description
This is the first book to exclusively address the actions of calcium-regulating hormones and peptides in the cardiovascular system. With 111 illustrations and 13 tables, this comprehensive volume includes: An extensive and critical review of present knowledge of the structure, synthesis, secretion, metabolism, receptors, signal transduction, and actions on classical target cells of each of the calcium-regulating hormones and peptides Discussions on parathyroid hormone and calcitonin, parathyroid hormone-related protein, parathyroid hypertensive factor, 1,25 dihydroxyvitamin D3, calcitonin gene-related peptide, and certain steroid hormones in terms of vascular biology and cardiac function The integrated physiology of calcium-regulating hormones in terms of blood pressure regulation in normotensive and hypertensive settings State-of-the-art electrophysiological techniques used by leading cardiovascular biologists to assess calciotropic hormone effects on calcium channel currents in both vascular smooth muscle and cardiac myocytes Studies on the regulation of hormone and receptor gene expression in the context of possible regulation of local and systemic blood flow and cardiac function by calcium-regulating hormones and peptides
Author:
Publisher: Academic Press
ISBN: 0124079385
Category : Science
Languages : en
Pages : 307
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Book Description
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Author: Heinrich Schmidt-Gayk
Publisher: Springer Science & Business Media
ISBN: 3662004062
Category : Medical
Languages : en
Pages : 336
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Book Description
Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are deA scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.
Author: Hirotoshi Morii
Publisher:
ISBN: 9783805553728
Category : Bone and Bones
Languages : en
Pages : 168
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Book Description
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
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Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Shaul Massry
Publisher: Springer Science & Business Media
ISBN: 1461342171
Category : Medical
Languages : en
Pages : 611
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Book Description
We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Author: Lindsay Biga
Publisher:
ISBN: 9781955101158
Category :
Languages : en
Pages :
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Book Description
A version of the OpenStax text
Author: Michael Henein
Publisher: Springer
ISBN: 9783030815172
Category : Medical
Languages : en
Pages : 0
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Book Description
The book systematically describes the clinical and scientific aspects of cardiovascular calcification. Chapters detail the mechanisms associated with arterial and valve calcification, relevant risk factors, pathophysiology and the latest therapeutic techniques. Recent diagnostic technological developments including how computed tomography (CT) scanning can be utilized along with Agatston score to quantify coronary arterial calcification when investigating whether a patient for sub-clinical atherosclerosis are covered. The correlation with the presence of arterial calcification and extent of coronary stenosis is also explored. Cardiovasular Calcification details relevant aspects of the basic science and reviews the latest pathological and therapeutic techniques used in treating patients with cardiovascular calcification. It is therefore an essential resource for practicing cardiologists, cardiac surgeons, vascular specialists and radiologists.
Author: Giorgio Iervasi
Publisher: Springer Science & Business Media
ISBN: 8847011434
Category : Medical
Languages : en
Pages : 264
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Book Description
Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.
