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Author: Caroline Carver
Publisher: Mysterious Press
ISBN: 0446562254
Category : Fiction
Languages : en
Pages : 232
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Book Description
A Mystery Guild Featured Alternate In a stunning debut novel that won her the prestigious Crime Writers' Association New Writer's Award, Caroline Carver presents a gutwrenching, provocative adventure thriller set against the eerie, exotic backdrop of the Australian Outback--where a woman's search for the truth about horrific crimes will bring her to the crossroads of her life.
Author: Caroline Carver
Publisher: Mysterious Press
ISBN: 0446562254
Category : Fiction
Languages : en
Pages : 232
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Book Description
A Mystery Guild Featured Alternate In a stunning debut novel that won her the prestigious Crime Writers' Association New Writer's Award, Caroline Carver presents a gutwrenching, provocative adventure thriller set against the eerie, exotic backdrop of the Australian Outback--where a woman's search for the truth about horrific crimes will bring her to the crossroads of her life.
Author: CJ Carver
Publisher: Simon and Schuster
ISBN: 1499861974
Category : Fiction
Languages : en
Pages : 296
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Book Description
A brutal murder; a dark and terrifying past Winner of the CWA Debut Dagger, CJ Carver's debut thriller is a dark and gripping story set in a town with a pitch-dark legacy of blood. "A nightmarish adventure of close calls and surprising escapes . . . An exceptional first mystery" Publishers Weekly Journalist India Kane's trip to the Australian outback takes a horrifying turn when she arrives in the town of Cooinda to find that her best friend Lauren is missing. Seemingly no one knows what has happened to her, but it's not long before India finds herself arrested for a double murder that she didn't commit, caught up in the dark past of a small town hiding a devastating truth - one that could destroy a family, a friendship, and a nation. Set in the unforgiving landscape of the Australian outback, Blood Junction won the CWA's Debut Dagger and is CJ Carver's powerful and compulsive thriller about a woman on the run from a brutal killer, as well as from her own past.
Author: Michael Fromm
Publisher: MDPI
ISBN: 3039432249
Category : Science
Languages : en
Pages : 412
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Book Description
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Author: Jianghui Hou
Publisher: Academic Press
ISBN: 0128226439
Category : Science
Languages : en
Pages : 422
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Book Description
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. - Provides consistent and detailed research methods - Covers various cell, tissue and animal models - Includes step-by-step guidance from beginner to sophisticated levels
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 576
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Book Description
Author: Howard E. Gendelman, MD
Publisher: Oxford University Press
ISBN: 0199875553
Category : Medical
Languages : en
Pages : 1156
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Book Description
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Author: Rutgers Scientific School
Publisher:
ISBN:
Category : Agricultural colleges
Languages : en
Pages :
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Book Description
Author: University College, London. Dept. of Physiology and Biochemistry
Publisher:
ISBN:
Category :
Languages : en
Pages : 314
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Book Description
Author: Anthony A. Nash
Publisher: Academic Press
ISBN: 0080571913
Category : Health & Fitness
Languages : en
Pages : 429
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Book Description
The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. - Attachment to and entry of microorganisms - Events occurring immediately after entry - The encounter of the microbe with the phagocytic cell - The spread of microbes through the body - The immune response to infection - Microbial strategies in relation to the immune response - Mechanisms of cell and tissue damage - Recovery from infection - Failure to eliminate the microbe - Host and microbial factors influencing susceptibility - Vaccines
Author: Detlev Boison
Publisher: Oxford University Press
ISBN: 0199322295
Category : Medical
Languages : en
Pages : 657
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Book Description
Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
