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Author: Walter H. Seegers
Publisher: Academic Press
ISBN: 1483225453
Category : Medical
Languages : en
Pages : 641
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Book Description
Blood Clotting Enzymology covers the mechanisms of blood clotting and their role in thrombosis, hemostasis, and many associated ramifications. This book is composed of 12 chapters that consider the integration of knowledge on blood clotting enzymology with hemostasis physiology. The opening chapter deals with the enzymology of the sol-gel transformation was studied in terms of proteins, fats, carbohydrates, surface physics, immunology, biophysical mechanisms, structural architecture, vitamin K and its antagonists, and the rheology of the blood. The subsequent chapters review the biophysical properties and composition of active substance in blood coagulation, as well as the concepts of prothrombin activation. These topics are followed by discussions on the chemical and physicochemical properties of fibrinogen and fibrin; the application of immulogical methods to delineate important properties of plasma constituents; and the mechanisms of antithrombin activity. Other chapters tackle the importance of hirudin and cobra venom for certain experimental laboratory work in the study of the physiology of blood coagulation. The final chapters survey the role of platelets in hemostasis, bleeding disorders, and the chemistry and function of vitamin K in blood coagulation. This book will prove useful to hematologists, enzyme scientist, immunologists, and research workers who are interested in blood coagulation mechanisms.
Author: Walter H. Seegers
Publisher: Academic Press
ISBN: 1483225453
Category : Medical
Languages : en
Pages : 641
Get Book Here
Book Description
Blood Clotting Enzymology covers the mechanisms of blood clotting and their role in thrombosis, hemostasis, and many associated ramifications. This book is composed of 12 chapters that consider the integration of knowledge on blood clotting enzymology with hemostasis physiology. The opening chapter deals with the enzymology of the sol-gel transformation was studied in terms of proteins, fats, carbohydrates, surface physics, immunology, biophysical mechanisms, structural architecture, vitamin K and its antagonists, and the rheology of the blood. The subsequent chapters review the biophysical properties and composition of active substance in blood coagulation, as well as the concepts of prothrombin activation. These topics are followed by discussions on the chemical and physicochemical properties of fibrinogen and fibrin; the application of immulogical methods to delineate important properties of plasma constituents; and the mechanisms of antithrombin activity. Other chapters tackle the importance of hirudin and cobra venom for certain experimental laboratory work in the study of the physiology of blood coagulation. The final chapters survey the role of platelets in hemostasis, bleeding disorders, and the chemistry and function of vitamin K in blood coagulation. This book will prove useful to hematologists, enzyme scientist, immunologists, and research workers who are interested in blood coagulation mechanisms.
Author: Jean-Paul Renaud
Publisher: John Wiley & Sons
ISBN: 1118900502
Category : Medical
Languages : en
Pages : 1437
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Book Description
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Author:
Publisher: Academic Press
ISBN: 0080865968
Category : Technology & Engineering
Languages : en
Pages : 471
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Book Description
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
Author: Barry M. McGrath
Publisher: CRC Press
ISBN: 1000611752
Category : Medical
Languages : en
Pages : 288
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Book Description
Carefully crafted to provide tightly focused and authoritative information, the Directory of Therapeutic Enzymes covers all approved therapeutic enzymes currently used in medicine. Written mainly by industry experts, the book includes information sourced directly from the company that developed or manufactured the product. It explores major
Author: John C. Griffiths
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 232
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Book Description
Author:
Publisher:
ISBN:
Category : Anticoagulants
Languages : en
Pages : 1364
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Book Description
Author: Thomas L. James
Publisher: Academic Press
ISBN:
Category : Science
Languages : en
Pages : 528
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Book Description
This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.
Author: P. Fondu
Publisher: Springer Science & Business Media
ISBN: 9780898386400
Category : Medical
Languages : en
Pages : 206
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Book Description
J. DE GROOTE One of the most ominous and troublesome complications of the liver disease is the appearance of hemorrhagic phenomena. Many careful clini cal observations about the relationship of liver function and of bilia ry tree pathology have been published. A vast amount of research work has been devoted to the subject. The severity of the hemorrhagic disor der is usually in relation to the liver disease. In mild chronic hepa titis or short lasting obstruction slight subcutaneous or mucosal blee ding may (lraw the attention of the patient and the doctor, but they are as such far from dangerous. However in acute hepatic insufficiency, in biliary cirrhosis the bleeding tendency is to be considered as a life threatening complication in about half of the cases. Moreover coagulation disturbances aggravate bleeding not only from ruptured oesophageal or gastric varices but also from gastritis or peptic ulcer. 11enometrorrhagia, epistaxis and gingival bleeding may be very trouble some in these conditions. The use of diagnostic procedures sucl. as liver puncture biopsy and peritoneoscopy are often impossible when platelets and prothrombine time are too low. In order to overcome this difficul ty a procedure has been worked out taking a biopsy through a trans jugular catheter placed in the hepatic vein. If a bleeding from the liver occurs it will be in the circulatory system and not cause any trouble.
Author: Russell F. Doolittle
Publisher: University Science Books
ISBN: 9781891389818
Category : Science
Languages : en
Pages : 0
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Book Description
llluminated by a great assortment of original illustrations, this remarkable book charts the step-by-step evolution of vertebrate blood coagulation. Intended for readers with a background in biological science, it is specifically targeted for those in the field of molecular evolution as well as for researchers in the area of blood clotting. After providing some general background in the areas of blood clotting, protein structure, animal systematics, and simple genomics, the book focusses in on the search for blood clotting genes in the genomes of non-mammalian vertebrates, including fish, amphibians, reptiles and birds. The inventory of genes found allows a reconstruction of events culminating in the complex clotting system observed in humans and other mammals. Also examined are the genomes of protochordates like the sea squirt, leading to conjecture about how blood clotting was first initiated. The orderly way in which gene duplications provided new genes for fine-tuning the system serves as a model for how complex physiological systems in general have evolved. The book ends with suggestions for specific genetic engineering experiments that can be done to illustrate how molecular evolution works. An extensive glossary and guide to the current literature combine to make this book ideal for course use as well as for self study.
Author: J. Jespersen
Publisher: Springer Science & Business Media
ISBN: 9780792364726
Category : Medical
Languages : en
Pages : 340
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Book Description
The first edition of this manual appeared in 1992 and was entitled ECAT Assay Procedures. This completely revised new edition combines the strengths of the first edition with new and useful features. Laboratory Techniques in Thrombosis - a Manual still gives detailed descriptions of the recommended assays and their alternatives. However, the manual now has a broader scope because it is no longer limited by the frontiers of ECAT. Experts all over the world have contributed to this edition. Furthermore, new assays have been introduced, improvements have been suggested for other assays, while a few others have become redundant or no longer available. The list of manufacturers is fully updated and a list of the recommended nomenclature of quantities in thrombosis and haemostasis is new to this edition, further facilitating the use of this manual. Laboratory Techniques in Thrombosis - a Manual will contribute to furthering the much needed harmonization and standardization of tests within the field and should have a place in all working haemostasis laboratories.
