Biological Imaging and Sensing Using Nanoparticle Assemblies PDF Download
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Author:
Publisher:
ISBN: 9781617387678
Category : Electrical engineering
Languages : en
Pages : 94
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Book Description
Author:
Publisher:
ISBN: 9781617387678
Category : Electrical engineering
Languages : en
Pages : 94
Get Book Here
Book Description
Author:
Publisher:
ISBN: 9781605112145
Category :
Languages : en
Pages :
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Book Description
Author: Ashutosh Tiwari
Publisher: John Wiley & Sons
ISBN: 1118773810
Category : Technology & Engineering
Languages : en
Pages : 423
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Book Description
This book provides detailed reviews of a range of nanostructures used in the construction of biosensors as well as the applications of these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields Biological sensing is a fundamental tool for understanding living systems, but also finds practical application in medicine, drug discovery, process control, food safety, environmental monitoring, defense, and personal security. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation, and computing. Advances in telecommunications, expert systems, and distributed diagnostics prompt us to question the current ways we deliver healthcare, while robust industrial sensors enable new paradigms in R&D and production. Despite these advances, there is a glaring absence of suitably robust and convenient sensors for body chemistries. This book examines some of the emerging technologies that are fueling scientific discovery and underpinning new products to enhance the length and quality of our lives. The 14 chapters written by leading experts cover such topics as: ZnO and graphene microelectrode applications in biosensing Assembly of polymers/metal nanoparticles Gold nanoparticle-based electrochemical biosensors Impedimetric DNA sensing employing nanomaterials Graphene and carbon nanotube-based biosensors Computational nanochemistry study of the BFPF green fluorescent protein chromophore Biosynthesis of metal nanoparticles Bioconjugated-nanoporous gold films in electrochemical biosensors The combination of molecular imprinting and nanotechnology Principles and properties of multiferroics and ceramics
Author: Hedi Mattoussi
Publisher: Artech House
ISBN: 1596931973
Category : Technology & Engineering
Languages : en
Pages : 332
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Book Description
This groundbreaking resource offers you an up-to-date account of the pioneering activity pushing new boundaries in the emerging area of inorganic nanoprobes and their use in biology and medicine. Written and edited by leading experts in the field, this unique book places particular emphasis nanoprobes made of luminescent semiconductor nanocrystals (quantum dots or QDs) and magnetic nanoparticles (MNPs). You find an insightful discussion on the synthesis, characterization, and analysis of the unique properties of luminescent QDs and MNPs.
Author: Nguyen Hoang Le
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Noble metal nanoparticles exhibit unique optical properties arising from the resonant oscillations of their conduction electrons with light. This phenomenon is called localized surface plasmon resonance (LSPR). The LSPR frequency is extremely sensitive to the size, shape, refractive index at the metal-dielectric interface, and other nearby metal nanoparticles. In an assembly of proximal nanoparticles, the LSPR of individual particles can couple to yield enhanced light scattering and large spectral shifts, which are useful for many applications including diagnostics and sensing. This dissertation presents a complex nanostructure comprising a core gold nanoparticle surrounded by multiple satellite gold nanoparticles for biosensing application. Chapter 2 introduces the fabrication and characterization of the core-satellite assemblies via a layer-by-layer process. Using ATP-aptamer as the linker, we demonstrated the detection of ATP based on the disassembly of the nanostructure, which can be readily captured by darkfield microscopy. The detection limit, dynamic range, and sensitivity can be tuned by controlling the size of the assembly. We found that the aptamer-linked nanoparticle assemblies were selective to only ATP, and not other adenine-containing compounds. Additionally, sensing of ATP in buffer and in bulk cell lysates was demonstrated. Chapter 3 presents the methodology for detecting ATP directly from lysed cells, down to the single-cell level without the need for purification or extraction. The intracellular ATP levels of two ovarian cancer cell lines were quantified to elucidate the differences and cellular distribution, and the potential of the stick-and-peel platform for mapping the microenvironment of 2D heterogeneous surfaces was demonstrated. In chapter 4, the optical properties of nanoparticle assemblies were tuned by changing the morphology of the nano building block, where the incorporation of gold nanoshells as satellites led to an extended redshift of LSPR to a much longer wavelength compared with using solid gold nanoparticles as satellites. This tunability in the LSPR of the assemblies allows for color-based analysis and color-coding of the plasmonic sensors. Lastly, Chapter 5 outlines the development of a multiplexed assay using the nanoparticle assemblies. Two types of assemblies, targeting either ATP or a nucleic acid (DNA-210), were fabricated with different DNA linkers in the same sensing area. The multiplexing was demonstrated by the selective disassembly process. Moreover, the ability to tune the optical properties of nanostructures using different morphologies was integrated; two different morphology of nanostructures, i.e. solid-solid and solid-shell nanostructures, for two targets, ATP and DNA-210, respectively, were fabricated. Based on a difference in scattered color, two types of biosensors among thousands of nanoparticle assemblies can be easily identified. Finally, we demonstrated duplex detection based on the change in the scattering intensity and the color read-out. Reflecting on the contributions of our work, this dissertation advances the fundamental knowledge and practical design of chip-based sensing platforms comprising complex plasmonic nanostructures. The work contributes to the sensing field by addressing some of the challenges in point-of-care or point-of-need measurement applications and provides an alternative bioanalytical tool for single-cell based analysis.
Author: Jeff W.M. Bulte
Publisher: Springer
ISBN: 3319421697
Category : Medical
Languages : en
Pages : 467
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Book Description
This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.
Author: Bansi D. Malhotra
Publisher: William Andrew
ISBN: 0128135158
Category : Technology & Engineering
Languages : en
Pages : 334
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Book Description
Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included. - Provides a detailed study on how nanomaterials are used to enhance sensing capabilities in biosensors - Explains the properties, characterization methods and preparation techniques of the nanomaterials used in biosensing - Arranged in a material-by-material way, making it clear how each nanomaterial should be used
Author: Suban K. Sahoo
Publisher: Elsevier
ISBN: 0323902456
Category : Technology & Engineering
Languages : en
Pages : 596
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Book Description
Sensing and Biosensing with Optically Active Nanomaterials summarizes the potential sensing applications of optically (chromogenic and fluorogenic) active, nano-sized, organic, and inorganic materials for the selective detection of ionic analytes (such as metal ions and anions) in various environmental and biological samples. Sections cover design, synthesis, sensing mechanisms and applications for detecting ionic analytes. Each chapter deals with the sensing applications of one kind of nanomaterial. This book is an important reference source for materials scientists and engineers seeking to increase their understanding on how nanomaterials are being used for sensing applications. - Provides information on the various types of optically active inorganic and organic nanomaterials, including quantum dots, SPR active noble metal nanoparticles, metal nanoclusters, organic nanoparticles and carbon dots - Summarizes the synthesis, design and development of sensors, along with their mechanisms - Explains major sensing applications and manufacturing challenges
Author: Alexandru Grumezescu
Publisher: Academic Press
ISBN: 0128043725
Category : Science
Languages : en
Pages : 928
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Book Description
Nanobiosensors: Nanotechnology in the Agri-Food Industry, Volume 8, provides the latest information on the increasing demand for robust, rapid, inexpensive, and safe alternative technologies that monitor, test, and detect harmful or potentially dangerous foods. Due to their high sensitivity and selectivity, nanobiosensors have attracted attention for their use in monitoring not only biological contaminants in food, but also potential chemical and physical hazards. This book offers a broad overview regarding the current progress made in the field of nanosensors, including cutting-edge technological progress and the impact of these devices on the food industry. Special attention is given to the detection of microbial contaminants and harmful metabolotes, such as toxins and hormones, which have a great impact on both humans and animal health and feed. - Includes the most up-to-date information on nanoparticles based biosensors and quantum dots for biological detection - Provides application methods and techniques for research analysis for bacteriological detection and food testing - Presents studies using analytical tools to improve food safety and quality analysis
Author: Sandra J Rosenthal
Publisher: Springer Science & Business Media
ISBN: 159259901X
Category : Science
Languages : en
Pages : 241
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Book Description
Hands-on experts in nanomaterial synthesis and application describe in detail the key experimental techniques currently employed in novel materials synthesis, dynamic cellular imaging, and biological assays. The author's emphasize diverse strategies to synthesize and functionalize the use of nanoparticles for biological applications. Additional chapters focus on the use of biological components (peptides, antibodies, and DNA) to synthesize and organize nanoparticles to be used a building block in larger assemblies. These new materials make it possible to image cellular processes for longer durations, leading to high throughput cellular-based screens for drug discovery, drug delivery, and diagnostic applications. Highlights include overview chapters on quantum dots and DNA nanotechnology, and cutting-edge techniques in the emerging nanobiotachnology arena.
