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Author: WILLIAN ORLANDO; CAJAS SALAZAR CASTILLO ORDONEZ
Publisher: Editorial Universidad del Cauca
ISBN: 9587325249
Category : Health & Fitness
Languages : es
Pages : 300
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Book Description
A nivel mundial, la enfermedad de Alzheimer es un creciente problema de salud pública. Los complejos matices de su expresión no solo afectan al paciente, sino también a la familia y al Estado. Un mejor entendimiento de su etiología, así como la búsqueda de alternativas dignas para una enfermedad compleja, son una tarea que precisa de la fuerza avasalladora de la biología. ‘Biología del alzhéimer: evolución y demencia’ es una obra que responde a ese desafío de democratización del conocimiento, a través de la exploración de este tipo de neurodegeneración. En esta obra, para una mejor comprensión, se han conjugado distintas disciplinas provenientes de la biología, tales como la evolución, la epidemiología, la anatomía, la genética y la epigenética, al igual que los nuevos desafíos que emergen de la bioinformática y la química estructural. La riqueza de esta integración está en que se concibe una imagen dinámica en la que se alcanza un texto ideal para quienes deseen ampliar su conocimiento sobre los mecanismos biológicos del síndrome del alzhéimer. De esta manera, pueden dimensionar más la realidad que viven aquellos que están al otro lado de esa fina línea que nos separa de su mundo: los pacientes con alzhéimer.
Author: WILLIAN ORLANDO; CAJAS SALAZAR CASTILLO ORDONEZ
Publisher: Editorial Universidad del Cauca
ISBN: 9587325249
Category : Health & Fitness
Languages : es
Pages : 300
Get Book Here
Book Description
A nivel mundial, la enfermedad de Alzheimer es un creciente problema de salud pública. Los complejos matices de su expresión no solo afectan al paciente, sino también a la familia y al Estado. Un mejor entendimiento de su etiología, así como la búsqueda de alternativas dignas para una enfermedad compleja, son una tarea que precisa de la fuerza avasalladora de la biología. ‘Biología del alzhéimer: evolución y demencia’ es una obra que responde a ese desafío de democratización del conocimiento, a través de la exploración de este tipo de neurodegeneración. En esta obra, para una mejor comprensión, se han conjugado distintas disciplinas provenientes de la biología, tales como la evolución, la epidemiología, la anatomía, la genética y la epigenética, al igual que los nuevos desafíos que emergen de la bioinformática y la química estructural. La riqueza de esta integración está en que se concibe una imagen dinámica en la que se alcanza un texto ideal para quienes deseen ampliar su conocimiento sobre los mecanismos biológicos del síndrome del alzhéimer. De esta manera, pueden dimensionar más la realidad que viven aquellos que están al otro lado de esa fina línea que nos separa de su mundo: los pacientes con alzhéimer.
Author: Don Kulasiri
Publisher: World Scientific
ISBN: 1800610130
Category : Medical
Languages : en
Pages : 416
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Book Description
Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.
Author: Robert Becker
Publisher: Springer Science & Business Media
ISBN: 1461241162
Category : Medical
Languages : en
Pages : 571
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Book Description
Author: David Dawbarn
Publisher: Oxford University Press
ISBN: 0191034584
Category : Medical
Languages : en
Pages :
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Book Description
Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associated proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.
Author: Ian Macreadie
Publisher: MDPI
ISBN: 3039214071
Category : Science
Languages : en
Pages : 228
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Book Description
Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.
Author: Robert Becker
Publisher:
ISBN: 9781461241171
Category :
Languages : en
Pages : 632
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Book Description
Author: Rudy Castellani
Publisher: Biota Publishing
ISBN: 1615046399
Category : Health & Fitness
Languages : en
Pages : 93
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Book Description
Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Author: Mathias Jucker
Publisher: Springer Science & Business Media
ISBN: 3540376526
Category : Medical
Languages : en
Pages : 541
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Book Description
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Author: J. Robin Harris
Publisher: Springer Science & Business Media
ISBN: 0387232265
Category : Science
Languages : en
Pages : 416
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Book Description
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Author: Ken S. Kosik
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 270
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Book Description
Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer's disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer's disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer's disease research opened with the iden tification of the component proteins in plaques and tangles.
