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Author: Florian Hahne
Publisher: Springer Science & Business Media
ISBN: 0387772405
Category : Science
Languages : en
Pages : 287
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Book Description
Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include: (1) import and preprocessing of data from various sources; (2) statistical modeling of differential gene expression; (3) biological metadata; (4) application of graphs and graph rendering; (5) machine learning for clustering and classification problems; (6) gene set enrichment analysis. Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.
Author: Florian Hahne
Publisher: Springer Science & Business Media
ISBN: 0387772405
Category : Science
Languages : en
Pages : 287
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Book Description
Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include: (1) import and preprocessing of data from various sources; (2) statistical modeling of differential gene expression; (3) biological metadata; (4) application of graphs and graph rendering; (5) machine learning for clustering and classification problems; (6) gene set enrichment analysis. Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.
Author: Robert Gentleman
Publisher: Springer Science & Business Media
ISBN: 0387293620
Category : Computers
Languages : en
Pages : 478
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Book Description
Full four-color book. Some of the editors created the Bioconductor project and Robert Gentleman is one of the two originators of R. All methods are illustrated with publicly available data, and a major section of the book is devoted to fully worked case studies. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.
Author: Juan R. González
Publisher: CRC Press
ISBN: 0429803362
Category : Mathematics
Languages : en
Pages : 356
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Book Description
After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions
Author: Nello Cristianini
Publisher: Cambridge University Press
ISBN: 9780521856034
Category : Computers
Languages : en
Pages : 200
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Book Description
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Author: Helen Causton
Publisher: John Wiley & Sons
ISBN: 1444311565
Category : Science
Languages : en
Pages : 176
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Book Description
This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression. Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly Short, concise text on this difficult topic area Clear illustrations throughout Written by well-known teachers in the subject Provides insight into how to analyse the data produced from microarrays
Author: Rafael A. Irizarry
Publisher: CRC Press
ISBN: 1498775861
Category : Mathematics
Languages : en
Pages : 537
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Book Description
This book covers several of the statistical concepts and data analytic skills needed to succeed in data-driven life science research. The authors proceed from relatively basic concepts related to computed p-values to advanced topics related to analyzing highthroughput data. They include the R code that performs this analysis and connect the lines of code to the statistical and mathematical concepts explained.
Author: Caroline St. Clair
Publisher: Jones & Bartlett Publishers
ISBN: 128402346X
Category : Computers
Languages : en
Pages : 309
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Book Description
Thoroughly revised and updated, Exploring Bioinformatics: A Project-Based Approach, Second Edition is intended for an introductory course in bioinformatics at the undergraduate level. Through hands-on projects, students are introduced to current biological problems and then explore and develop bioinformatic solutions to these issues. Each chapter presents a key problem, provides basic biological concepts, introduces computational techniques to address the problem, and guides students through the use of existing web-based tools and software solutions. This progression prepares students to tackle the On-Your-Own Project, where they develop their own software solutions. Topics such as antibiotic resistance, genetic disease, and genome sequencing provide context and relevance to capture student interest.
Author: Joseph Adler (M.Eng.)
Publisher: "O'Reilly Media, Inc."
ISBN: 1449358233
Category : Mathematical statistics
Languages : en
Pages : 722
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Book Description
If you're considering R for statistical computing and data visualization, this book provides a quick and practical guide to just about everything you can do with the open source R language and software environment. You'll learn how to write R functions and use R packages to help you prepare, visualize, and analyze data. Author Joseph Adler illustrates each process with a wealth of examples from medicine, business, and sports. Updated for R 2.14 and 2.15, this second edition includes new and expanded chapters on R performance, the ggplot2 data visualization package, and parallel R computing with Hadoop. Get started quickly with an R tutorial and hundreds of examples Explore R syntax, objects, and other language details Find thousands of user-contributed R packages online, including Bioconductor Learn how to use R to prepare data for analysis Visualize your data with R's graphics, lattice, and ggplot2 packages Use R to calculate statistical fests, fit models, and compute probability distributions Speed up intensive computations by writing parallel R programs for Hadoop Get a complete desktop reference to R.
Author: Yanchang Zhao
Publisher: Academic Press
ISBN: 012397271X
Category : Mathematics
Languages : en
Pages : 251
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Book Description
R and Data Mining introduces researchers, post-graduate students, and analysts to data mining using R, a free software environment for statistical computing and graphics. The book provides practical methods for using R in applications from academia to industry to extract knowledge from vast amounts of data. Readers will find this book a valuable guide to the use of R in tasks such as classification and prediction, clustering, outlier detection, association rules, sequence analysis, text mining, social network analysis, sentiment analysis, and more.Data mining techniques are growing in popularity in a broad range of areas, from banking to insurance, retail, telecom, medicine, research, and government. This book focuses on the modeling phase of the data mining process, also addressing data exploration and model evaluation.With three in-depth case studies, a quick reference guide, bibliography, and links to a wealth of online resources, R and Data Mining is a valuable, practical guide to a powerful method of analysis. - Presents an introduction into using R for data mining applications, covering most popular data mining techniques - Provides code examples and data so that readers can easily learn the techniques - Features case studies in real-world applications to help readers apply the techniques in their work
Author: Joseph Adler
Publisher: "O'Reilly Media, Inc."
ISBN: 1449389325
Category : Computers
Languages : en
Pages : 635
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Book Description
Why learn R? Because it's rapidly becoming the standard for developing statistical software. R in a Nutshell provides a quick and practical way to learn this increasingly popular open source language and environment. You'll not only learn how to program in R, but also how to find the right user-contributed R packages for statistical modeling, visualization, and bioinformatics. The author introduces you to the R environment, including the R graphical user interface and console, and takes you through the fundamentals of the object-oriented R language. Then, through a variety of practical examples from medicine, business, and sports, you'll learn how you can use this remarkable tool to solve your own data analysis problems. Understand the basics of the language, including the nature of R objects Learn how to write R functions and build your own packages Work with data through visualization, statistical analysis, and other methods Explore the wealth of packages contributed by the R community Become familiar with the lattice graphics package for high-level data visualization Learn about bioinformatics packages provided by Bioconductor "I am excited about this book. R in a Nutshell is a great introduction to R, as well as a comprehensive reference for using R in data analytics and visualization. Adler provides 'real world' examples, practical advice, and scripts, making it accessible to anyone working with data, not just professional statisticians."
