Biochemistry of Diabetes and Atherosclerosis PDF Download
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Author: James S.C. Gilchrist
Publisher: Springer Science & Business Media
ISBN: 1441992367
Category : Science
Languages : en
Pages : 179
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Book Description
Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes. This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.
Author: James S.C. Gilchrist
Publisher: Springer Science & Business Media
ISBN: 1441992367
Category : Science
Languages : en
Pages : 179
Get Book
Book Description
Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes. This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.
Author: Belma Turan
Publisher: Springer Science & Business Media
ISBN: 146149317X
Category : Science
Languages : en
Pages : 423
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Book Description
Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.
Author: Alicia J. Jenkins
Publisher: Springer Science & Business Media
ISBN: 1461475546
Category : Medical
Languages : en
Pages : 468
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Book Description
Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.
Author: Sukhinder C. Kaur
Publisher: Springer Science & Business Media
ISBN: 0387362797
Category : Medical
Languages : en
Pages : 580
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Book Description
This book covers many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. It includes all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. Also explored are the roles of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. The book further discusses how genetic studies can help understand the complexities that mediate these aspects of atherogenesis.
Author: Grant N. Pierce
Publisher: Springer Science & Business Media
ISBN: 1441992324
Category : Medical
Languages : en
Pages : 528
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Book Description
This volume is devoted to atherosclerosis, hypertension, and diabetes, three of the most important disease conditions in the world today. Nutritional intervention, cholesterol lowering agents, lipids themselves, particularly oxidized LDL, protein modification by ADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are all discussed in the context of atherosclerotic cardiovascular disease. The hypertension section focuses on factors that may be responsible for high blood pressure, such as genetic predisposition, vascular hyperplasia and remodeling, insulin resistance, neurological aspects such as hypothalamic peptides. Also discussed are the possible contributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drug delivery for treatment of hypertension is also a focus. The risk factors and mechanisms responsible for diabetic vascular and cardiac dysfunction are discussed. Lipid profile changes and fibrinolysis in diabetic patients is detailed, along with adipogenesis, diabetic cardiomyopathy, energy metabolism in the diabetic heart, vanadate as an alternative to insulin, insulin resistance mechanisms, and neurotransmitters as targets for the prevention of cardiovascular disease and diabetes.
Author: J. Vallance-Owen
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 224
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Book Description
Author: Neil Ruderman
Publisher: Springer
ISBN: 1461475244
Category : Medical
Languages : en
Pages : 307
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Book Description
It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.
Author: Rafael A. Camerini-Dávalos
Publisher: Academic Press
ISBN: 1483215555
Category : Medical
Languages : en
Pages : 623
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Book Description
Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries. Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful.
Author: European Atherosclerosis Group. Meeting
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 196
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Book Description
The book features clinical and experimental data covering four major topics. General treatment of hyperlipidaemias is reviewed including the efficacy of different drugs. Benefits of treatment by the Lipid Research Clinics Coronary Primary Prevention Trial are shown. The second topic comprises the epidemiological aspects of diabetes. Diabetes and lipoprotein metabolism is the subject of the third are considered. VLDL metabolism and apoprotein metabolism are reviewed and complimented by a general consideration of protein glycosylation and the possible pathophysiological consequences of the glycosylation of LDL and HDL. The final topic reflects the growing interest in the molecural biology of hyperlipidaemias. The genetic determinants of hyperlipidaemias are reviewed as well as links between genetic disorders, diabetes and hyperlipidaemias. [Editeur]
Author: Enrique Z. Fisman
Publisher: Karger Medical and Scientific Publishers
ISBN: 380558427X
Category : Medical
Languages : en
Pages : 189
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Book Description
The prevalence of obesity, metabolic syndrome and diabetes - three links of the same 'atherothrombotic chain' - has reached pandemic proportions worldwide. As a result, our civilization is at war against a threatening enemy: cardio-diabetes. Several independent physiological processes underlie the clustering of cardio-diabetes, including central obesity, insulin resistance, dyslipidemia, inflammation, impaired glucose tolerance, and hypertension. Early detection is of overwhelming importance for public health. The complex and intimate relationship between cardiovascular disease and diabetes from basic science to clinical and therapeutic concerns is discussed in this outstanding book. Beginning with molecular, biochemical, inflammatory and cellular aspects, this publication continues with histological and pathophysiological issues, details particular problems in specific metabolic and clinical settings, and finally analyzes several aspects of clinical pharmacology focusing on the optimal management of combined dyslipidemia and non-insulin antidiabetic therapy in cardiac diabetic patients. This book will be a gain in knowledge for every cardiologist, diabetologist, specialist in internal medicine, nutritionalist, general physician and medical student.
