Author: F. Rossi
Publisher: Springer Science & Business Media
ISBN: 146848088X
Category : Science
Languages : en
Pages : 685
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Book Description
This volume collects the papers presented at the "Second Euro pean Conference on Phagocytic Leucocytes" which was held in Trieste, September 15-18, 1980. The Conference was the continuation of the thread of a discourse initiated with the "First European Conference on Phagocytic Leucocytes," which was held also in Trieste in 1976. In fact, in both Conferences the biochemical aspects of the basic functions of phagocytes--that is movement, metabolism, secretion, and bactericidal activity--were mainly emphasized. In the Second Confer ence, two additional subjects were also dealt with, and those are the tumoricidal activity of phagocytes and the clinical aspects of phagocyte functions. In connection with the latter subject a "Round Table on the Clinical Application of Leucocyte Function Tests" was held during the Conference, and the proceedings are reported in this book in the hope that they may be useful to those who are interested in the relationship between phagocytes and diseases. The number of papers which are being published concerning the phagocytic process is such that one wonders whether publication of a new book in this field is necessary. However, the philosophy which inspired the edi ting of this book differs from that underlying publication of origi nal articles in scientific journals. We started from the common notion that the real progress of our knowledge is not necessarily proportional to the amount of published material in that specific field.
Author: Maurice B. Hallett
Publisher: Springer Nature
ISBN: 3030404064
Category : Medical
Languages : en
Pages : 194
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Book Description
Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
Author: Margaret Ackerman
Publisher: Academic Press
ISBN: 0123948185
Category : Medical
Languages : en
Pages : 376
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Book Description
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system
Author: R. van Furth
Publisher: Springer Science & Business Media
ISBN: 9400987935
Category : Medical
Languages : en
Pages : 1949
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Book Description
Author: Davide Malagoli
Publisher: Academic Press
ISBN: 012802013X
Category : Medical
Languages : en
Pages : 384
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Book Description
The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. - Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms - Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology - Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization - Brings concepts and ideas on the evolution of the immune system to a wide readership
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: An-Long Xu
Publisher: Elsevier
ISBN: 0128096470
Category : Medical
Languages : en
Pages : 306
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Book Description
Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: - Amphioxus as a model for understanding the evolution of vertebrates - basic knowledge of immunology - immune organs and cells of amphioxus - a genomic and transcriptomic view of the Amphioxus immunity - pattern recognition system in Amphioxus - transcription factors in Amphioxus - the complement system of Amphioxus - the oxidative burst system in Amphioxus - immune effectors in Amphioxus - lipid signaling of immune response in Amphioxus - apoptosis in amphioxus; primitive adaptive immune system of Amphioxus - and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. - Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms - Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity - Includes much pioneering work, from the molecular, genomic, and cellular to the individual level
Author: Joel D. Ernst
Publisher: Cambridge University Press
ISBN: 1139458051
Category : Science
Languages : en
Pages : 273
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Book Description
This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.
Author: Christopher D. Gregory
Publisher: Springer
ISBN: 3319394061
Category : Medical
Languages : en
Pages : 260
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Book Description
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Author: Mark T. Quinn
Publisher: Springer Science & Business Media
ISBN: 1588297888
Category : Medical
Languages : en
Pages : 1099
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Book Description
This book provides a concise set of protocols for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step-by-step diagnostic assays of common neutrophil disorders. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Scientists and clinicians will find this collection an invaluable aid.
