Cell Surface Receptors: A Short Course on Theory and Methods PDF Download
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Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 1461312558
Category : Medical
Languages : en
Pages : 251
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Book Description
Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.
Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 1461312558
Category : Medical
Languages : en
Pages : 251
Get Book Here
Book Description
Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.
Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 0387230807
Category : Medical
Languages : en
Pages : 226
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Book Description
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.
Author: Samuel Epstein
Publisher: John Wiley & Sons
ISBN: 0470754699
Category : Language Arts & Disciplines
Languages : en
Pages : 336
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Book Description
Derivation and Explanation in the Minimalist Program presents accessible, cutting edge research on an enduring and fundamental question confronting all linguistic inquiry – the respective roles of derivation and representation. Presents accessible, cutting edge research on the respective roles of derivation and representation in syntactic inquiry. Discusses a wide range of phenomena and also includes alternative, representational perspectives. Features papers by M. Brody, C. Collins, S. Epstein, J. Frampton, S. Gutmann, N. Hornstein, R. Kayne, H. Kitahara, J. McCloskey, N. Richards, D. Seely, E. Torrego, J. Uriagereka, C.J.W. Zwart.
Author: Mike Gore
Publisher: OUP Oxford
ISBN: 0191566055
Category : Science
Languages : en
Pages : 387
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Book Description
Spectrophotometry and Spectrofluorimetry: A Practical Approach Second Edition was written with the intention to help the reader understand the background concepts and practical applications of spectrophotometry and spectrofluorimetry. Optical spectroscopy underpins the day to day operations of most laboratories in the chemical, biological and medical sciences and this edition contains substantially updated and new chapters addressing the principles of most of the more common applications such as: spectrophotometry, spectrophotometric assays, spectrofluorimetry, time resolved fluorescence and phosphorescence studies, circular dichrosim and pre-equilibrium spectroscopic techniques. In all chapters, the emphasis is placed upon the practical aspects, with protocols to guide readers through test experiments. Other chapters are included to introduce subjects that have traditionally depended upon spectroscopy such as basic enzyme kinetics, ligand binding, data handling and the more recently established interest in the study of protein and DNA stability. Finally, the concept of 'global analysis' is introduced to provide the reader with an insight into this method of utilizing the vast arrays of experimental data provided by current instrumentation.
Author: E. Sélégny
Publisher: Springer Science & Business Media
ISBN: 9401021856
Category : Science
Languages : en
Pages : 536
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Book Description
This book contains a number of articles inspired by the NATO Advanced Study Institute on 'Charged and Reactive Polymers l' held in France in June 1972. This general title indicates simply the intention of a series. The meeting dealt mainly with the fundamental problems of the physical chemistry of polyelectrolytes in solution. Some of the articles reproduce the lectures exactly as they were delivered. Some others have been modified to a greater or lesser extent, and this as a result of improvements or new inspiration arising from comments and discussions. In previous larger conferences on macromolecules, polyelectrolytes constituted only a marginal problem and few were the individual communications or short was the time al10tted to this subject. In other meetings of a biophysical character the uses of the techniques of charged macromolecules have been exposed with less attention given to the theories or to the creation or interpretation of these techniques. AU of us felt that the time had come to enumerate and to evaluate this increasing science of polyelectrolytes which has become of major interest. During the whole period of the Institute physical chemists discussed their mutual problems for more than a week, and of ten far into the night! One of the advantages of such an Institute is to enable the Directors and the mem bers of the Scientific Committee to establish a logical order in the lectures; this order has been respected in the present edition.
Author: Terry P. Kenakin
Publisher: Elsevier
ISBN: 0124076890
Category : Medical
Languages : en
Pages : 451
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Book Description
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research. - Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery - Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules - Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Author: Jim E. Riviere
Publisher: John Wiley & Sons
ISBN: 0470959886
Category : Medical
Languages : en
Pages : 456
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Book Description
Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
Author: Mei Deming
Publisher: Taylor & Francis
ISBN: 104008544X
Category : Language Arts & Disciplines
Languages : en
Pages : 369
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Book Description
This book explores the major theories of generative grammar from a historical perspective, providing an overview of the evolution of this linguistic framework. Generative grammar is widely recognized for its major contributions to the study of theoretical linguistics in the twentieth century and has had a profound impact on the fields of linguistics, psychology, computer science, and cognitive science. This book consists of eight chapters that trace the development of generative grammar from its beginnings to its current focus on minimalism. The first chapter outlines the major stages of generative grammar, namely Classical Theory, Standard Theory, Extended Standard Theory, Revised Extended Standard Theory, Government and Binding Theory, and the Minimalist Program. The second chapter reviews the development of the C‐command relation and illustrates its use in syntactic analysis. Each of the following six chapters focuses on a specific area of generative grammar, including phrase structure, movement, Case, argument structure, binding, and raising and control. The volume will be an invaluable resource for researchers, teachers, and students in the fields of generative grammar, syntax, formal linguistics, and the social and cognitive sciences.
Author: Philip Molyneux
Publisher: CRC Press
ISBN: 1351094521
Category : Science
Languages : en
Pages : 308
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Book Description
Although several monographs and reviews have appeared on individual polymers of this type, and their applications and other technical aspects have also been discussed, this is apparently the first book to deal with the physical chemistry of water-soluble synthetic polymers as a group. This collective survey enables their properties and behaviour to be compared, and to be correlated with their molecular structures for predictive purposes. However, this has made it necessary to critically re-appraise much of the earlier fundamental work, so that current discussion of more recent work can be put on ta proper basis. Thus, of the 1800 or so references cited, the middle two-thirds related to the twenty-year period centred on about 1968. Nevertheless, sufficient key recent references have also been included so that the existing ‘state of the art is delineated.
Author: Michael L. Johnson
Publisher: Academic Press
ISBN: 0080923402
Category : Science
Languages : en
Pages : 519
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Book Description
In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. The use of thermodynamics in biological research is used as an "energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well.
