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Author: José-Luis Capelo-Martínez
Publisher: John Wiley & Sons
ISBN: 1119282527
Category : Medical
Languages : en
Pages : 730
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Book Description
This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Author: José-Luis Capelo-Martínez
Publisher: John Wiley & Sons
ISBN: 1119282527
Category : Medical
Languages : en
Pages : 730
Get Book Here
Book Description
This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Author: Hartmut Derendorf
Publisher: Lippincott Williams & Wilkins
ISBN: 1496385896
Category : Medical
Languages : en
Pages : 1334
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Book Description
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Author: Robert B. Morin
Publisher: Academic Press
ISBN: 1483277194
Category : Medical
Languages : en
Pages : 594
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Book Description
Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Author: Alle Bruggink
Publisher: Springer Science & Business Media
ISBN: 9401008507
Category : Science
Languages : en
Pages : 328
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Book Description
Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author: Warren Turner
Publisher: Elsevier Health Sciences
ISBN: 0702036331
Category : Medical
Languages : en
Pages : 491
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Book Description
The eagerly awaited new edition of Clinical Skills in Treating the Foot has been revised and updated with the needs of a broad range of health professionals in mind. For anyone treating patients with foot disorders, Clinical Skills in Treating the Foot will provide invaluable support through three key areas: Section 1 is concerned with the general principles of managing foot disorders and the context in which treatment of the foot takes place. Included are chapters on treatment planning, evidence based practice, governance and audit, clinical protocols, clinical emergencies and health promotion. Section 2 examines the application of clinical therapeutics to foot disease and includes chapters on operative techniques, surgery and the foot, pharmacology, physical therapy, mechanical therapeutics, chairside devices, prescription devices and footwear therapy. Section 3 considers the particular needs of special groups and includes chapters on the adult foot, the child's foot, sports injuries and management of tissue viability. With its clarity of text and liberal use of case studies and illustrations, the latest edition of Clinical Skills will be required reading for practising and student podiatrists. It will also be a valuable reference and guide for all others involved in the provision of treatment of the foot. This book has been written as a companion volume to the editors' Assessment of the Lower Limb, also published by Elsevier Churchill Livingstone. - Written by an experienced team of clinicians who also understand the needs of students as well as practitioners - Logical and clear structure makes it easy to use for both clinicians and students - Each chapter is self-contained and can be used for independent reading topics - Case histories and clinical comment sections illustrate important clinical points - Key points and summaries provides assistance for learning and review - Features approximately 400 illustrations - Half of the contributors are new - more experienced clinicians than those used for the previous edition - New chapter by new author on Clinical Governance (replacing old chapter of Audit and Outcome Measurement) - Major revision by new authors of chapter on Treatment Planning to reflect new developments and changes in pracice - Completely rewritten chapter by new authors on Clinical protocols - Major revision by new author of the chapter on Foot health education and promotion - Major rewrite with new author of the chapter on Pharmacology which will have expanded sections on topical and injected steroids and prescription medicines. - Major revision by new authors of the chapter on Physical therapy - New section on chairside devices in the chapter on Mechanical therapeutics in the clinic (new authors involved) - Chapter on Prescription orthoses now replaced with new chapter by new authors on Prescription devices.. - Major rewrite by new author of the chapter on sports injuries - New chapter on Managing tissue viability repaces the old chapter on the Management of foot ulcers and now incorporates the material previously covered in old appendices 1 and 2 on Management of exudation in ulcers and Footcare advice for people with diabetes.
Author: Gwyn Macfarlane
Publisher: Vintage
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 340
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Book Description
Author: Thomas J. Dougherty
Publisher: Springer Science & Business Media
ISBN: 1461414008
Category : Medical
Languages : en
Pages : 1119
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Book Description
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author: Bimal K. Banik
Publisher: Springer
ISBN: 3319556215
Category : Science
Languages : en
Pages : 423
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Book Description
This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Author: Marc E. de Broe
Publisher: Springer Science & Business Media
ISBN: 1402025866
Category : Medical
Languages : en
Pages : 719
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Book Description
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Author: Bimal Krishna Banik
Publisher: CRC Press
ISBN: 1040146619
Category : Science
Languages : en
Pages : 410
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Book Description
Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams Microwave, ultrasound, and solid support-mediated preparation of beta-lactams Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science Synthesis and mechanism of formation of polyaromatic beta-lactams
