Mutagenicity: Assays and Applications

Mutagenicity: Assays and Applications PDF Author: Ashutosh Kumar
Publisher: Academic Press
ISBN: 0128092602
Category : Science
Languages : en
Pages : 352

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Book Description
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Mutagenicity: Assays and Applications

Mutagenicity: Assays and Applications PDF Author: Ashutosh Kumar
Publisher: Academic Press
ISBN: 0128092602
Category : Science
Languages : en
Pages : 352

Get Book Here

Book Description
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Handbook of Mutagenicity Test Procedures

Handbook of Mutagenicity Test Procedures PDF Author: B.J. Kilbey
Publisher: Elsevier
ISBN: 0444600981
Category : Medical
Languages : en
Pages : 876

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Book Description
The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Mutagenicity Testing

Mutagenicity Testing PDF Author: S. Venitt
Publisher:
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 378

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Book Description
LABORATORY MANUAL. GENETIC TOXICOLOGY. BACTERIA. YEAST. FRUIT FLY. CULTURED MAMMALIAN CELLS. CYTOGENETIC TESTING. RODENTS. DOMINANT LETHAL TEST.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264071245
Category :
Languages : en
Pages : 12

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Book Description
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...

Statistical Evaluation of Mutagenicity Test Data

Statistical Evaluation of Mutagenicity Test Data PDF Author: David J. Kirkland
Publisher: Cambridge University Press
ISBN: 9780521048149
Category : Medical
Languages : en
Pages : 316

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Book Description
This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Statistical Methods in Toxicology

Statistical Methods in Toxicology PDF Author: Ludwig Hothorn
Publisher: Springer Science & Business Media
ISBN: 364248736X
Category : Medical
Languages : en
Pages : 158

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Book Description
This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Basic Mutagenicity Tests

Basic Mutagenicity Tests PDF Author: David J. Kirkland
Publisher: Cambridge University Press
ISBN: 9780521393478
Category : Medical
Languages : en
Pages : 164

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Book Description
A summary of the essential texts that must be performed on all new compounds before they can be registered for use in the UK.

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264122818
Category :
Languages : en
Pages : 16

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Book Description
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...

Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test

Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264243178
Category :
Languages : en
Pages : 13

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Book Description
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells

Test No. 478: Rodent Dominant Lethal Test

Test No. 478: Rodent Dominant Lethal Test PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264243119
Category :
Languages : en
Pages : 15

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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...