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Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 388
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Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 388
Get Book Here
Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author: Oscar Alzate
Publisher: CRC Press
ISBN: 1420076264
Category : Medical
Languages : en
Pages : 356
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Book Description
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Author: Charles Judson Herrick
Publisher:
ISBN:
Category : Nervous system
Languages : en
Pages : 404
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Book Description
Author: John Barton Furness
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 312
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Book Description
Author: Nicholas T. Carnevale
Publisher: Cambridge University Press
ISBN: 1139447831
Category : Medical
Languages : en
Pages : 399
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Book Description
The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Edward Koenig
Publisher: Springer Science & Business Media
ISBN: 364203019X
Category : Science
Languages : en
Pages : 369
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Book Description
Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration. Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities.
Author: Nick Draper
Publisher: Taylor & Francis
ISBN: 1003800386
Category : Medical
Languages : en
Pages : 623
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Book Description
This second edition of Exercise Physiology: For Health and Sports Performance brings together all the essential human anatomy and applied physiology that students of exercise science, physical education, and sports coaching will need to know. Written in a friendly, accessible style, and containing a wide range of features to help develop understanding, this book provides a complete one-stop shop for exercise physiology broken down into three fundamental parts: foundations of exercise physiology, applied exercise physiology, and the new Part 3, exercise prescription. With Parts 1 and 2 examining the theory, testing, and practical applications of exercise physiology, the new Part 3 reflects the changes in the field by increasing focus on physical activity and diverse populations and helps provides a more complete course text for any exercise physiology course at universities around the world. This newly revised book is key reading for undergraduate and postgraduate students in the fields of exercise physiology, sports performance, sports therapy, fitness and personal training, and other related sport science courses.
Author: Kathleen Rockland
Publisher: Academic Press
ISBN: 0128016825
Category : Science
Languages : en
Pages : 427
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Book Description
Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging. - A novel innovative reference on the axon as a connectional unit, encompassing microcircuitry, axon guidance, and function - Featuring chapters from leading researchers in the field - Full-colour text that includes both an overview of axon function and the multiple underlying molecular mechanisms - The only volume to bring together the configuration of individual axons at a circuit level and to relate the histological geometry of axons and axon bundles to in vivo tractography imaging studies
Author: Walter H. Hörl
Publisher: Springer Science & Business Media
ISBN: 1402022751
Category : Medical
Languages : en
Pages : 1640
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Book Description
The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester. This new edition is truly global in scope and features the contributions of the top experts from around the world.
