Asymmetric Catalysis with a C2-symmetric Bisoxazolidine and Enantioselective Sensing Using Axially Chiral Diacridylnaphthalenes PDF Download
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Author: Shuanglong Liu
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 424
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Book Description
Author: Shuanglong Liu
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 424
Get Book Here
Book Description
Author: Xuefeng Mei
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 450
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Book Description
Author: Christian Wolf
Publisher: Royal Society of Chemistry
ISBN: 0854042466
Category : Education
Languages : en
Pages : 534
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Book Description
A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.
Author: w Lough
Publisher: Springer Science & Business Media
ISBN: 940090861X
Category : Science
Languages : en
Pages : 278
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Book Description
While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.
Author: Fumio Toda
Publisher: Springer Science & Business Media
ISBN: 1402023375
Category : Science
Languages : en
Pages : 334
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Book Description
In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Author: Klaus Anton
Publisher: CRC Press
ISBN: 9780824700133
Category : Science
Languages : en
Pages : 504
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Book Description
From the analytical to industrial preparative scale, this work provides a praxis-oriented overview of packed column supercritical fluid chromatography. It discusses and evaluates established applications and techniques, up-to-date and promising developments, and commercial instrumentation devices for use in industry. The book also reveals possibilities for problem solving and future innovations.
Author: Vitomir Sunjic
Publisher: Springer Science & Business Media
ISBN: 3034801254
Category : Medical
Languages : en
Pages : 249
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Book Description
Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry. The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.
