Author: Navjeet Kaur
Publisher: Elsevier
ISBN: 0443220603
Category : Science
Languages : en
Pages : 354
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Book Description
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures. The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine. Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. - Focuses on the biological importance of different heterocycles - Describes traditional and innovative methods for the synthesis of aziridines from imines - Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
Author: Navjeet Kaur
Publisher: Elsevier
ISBN: 0443192057
Category : Science
Languages : en
Pages : 387
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Book Description
Synthesis of Azetidines from Imines by Cycloaddition Reactions presents several methodologies for the synthesis of azetidines from imines by cycloaddition reactions. The azetidines, known as important contribution of science to humanity, are important organic compounds that have occupied a basic position in the pharmaceutical chemistry for over a hundred years because of their biological activities. They are the fundamental skeleton of several antibiotics, probiotics and alkaloids. The synthesis of azetidines is a constant challenge for medicinal chemists, hence this book comprehensively describes azetidine ring synthesis. With this book, readers will be able to quickly assess possible synthetic approaches and evaluate whether preparation of a four-membered nitrogen containing ring is reasonable. - Highlights cycloaddition reactions of imines - Covers the synthesis of azetidines
Author: Bagher Eftekhari-Sis
Publisher: CRC Press
ISBN: 1000733912
Category : Science
Languages : en
Pages : 295
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Book Description
This comprehensive text covers the research and development trends in the growing field of aromatic C–H dehydrogenative coupling reactions, leading to different types of heterocycles. The author provides answers to how these coupling reactions occur, what kinds of heterocycles are synthesized, and what their advantages are. The palladium-, rhodium-, iridium-, copper-, cobalt-, ruthenium-, and ferric-catalyzed aromatic C(sp2)–H dehydrogenative cross-coupling reactions are described in detail. A useful reference source for researchers and graduates in the field of heterocyclic chemistry and transition-metal-catalyzed dehydrogenative coupling reactions. Features: Comprehensive volume on the synthesis of benzo-heterocycles via aromatic C(sp2)–H bond activation. Heterocycles are of paramount importance to medicinal chemistry and drug discovery. Provides a comprehensive literature survey on the construction of heterocycles. Reaction procedures and mechanistic explanations are included, which will appeal to those in fine chemicals and pharmaceutical companies.
Author: Edwin Vedejs
Publisher: John Wiley & Sons
ISBN: 3527675159
Category : Science
Languages : en
Pages : 1488
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Book Description
This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Author: Vittorio Caprio
Publisher: John Wiley & Sons
ISBN: 1405190914
Category : Science
Languages : en
Pages : 409
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Book Description
Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.
Author: Boy Cornils
Publisher: John Wiley & Sons
ISBN: 3527651764
Category : Science
Languages : en
Pages : 1770
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Book Description
The completely revised third edition of this four-volume classic is fully updated and now includes such topics as as CH-activation and multicomponent reactions. It describes the most important reaction types, new methods and recent developments in catalysis. The internationally renowned editors and a plethora of international authors (including Nobel laureate R. Noyori) guarantee high quality content throughout the book. A "must read" for everyone in academia and industry working in this field.
Author: Lutz Ackermann
Publisher: John Wiley & Sons
ISBN: 3527340130
Category : Technology & Engineering
Languages : en
Pages : 414
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Book Description
Filling a gap in the literature, this book comprehensively reviews catalytic C-H addition reactions of (hetero)aromatic hydrocarbons across carbon-carbon multiple bonds. In so doing, it summarizes both the scope as well as the limitations of different catalyst systems and building blocks, while highlighting their application to the synthesis of pharmaceuticals as well as commodity chemicals. Focusing on the latest developments, the team of authors comprising leaders in the field covers such topics as the hydroarylation of olefins, alkyne hydroarylation in the presence of transition metal catalysts, reaction of alkynes with arylboronic acids, and allene hydroarylation, as well as the synthesis of functionalized arenes and heteroaromatics. A must-have for synthetic chemists in academia and industry dealing with catalysis, organometallic chemistry, the synthesis of natural products, fine chemicals, pharmaceuticals, products of the chemical industry and organic materials.
Author: Giorgio Della Sala
Publisher: MDPI
ISBN: 3036509720
Category : Science
Languages : en
Pages : 172
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Book Description
The synthesis of enantiopure organic compounds is a key issue for several applications in pharmacology, food chemistry, agricultural chemistry, perfumery, materials science and other industrial sectors. Nowadays, asymmetric catalysis is undoubtedly the most important tool to achieve this goal. This technology, in fact, enables the production of large amounts of enantiomerically enriched compounds, employing relatively small quantities of chiral enantiopure catalysts, which is exactly what is accomplished by enzymes in nature. Since the pioneering works of Noyori, Knowles and Sharpless, which later earned them the Nobel Prize in Chemistry, asymmetric catalysis has experienced a rapid and relentless development in the last fifty years. The tremendous expansion of enantioselective transformations, the design of novel and more efficient organometallic and organic catalysts, the development of sophisticated bioreactors and cell factories, are just some of the elements responsible for such growth. However, new challenges of asymmetric catalysis are devoted to enhancing the process’s sustainability, by the introduction of recyclable and low-cost catalysts, and the use of renewable starting materials and energy source. This book provides an overview of some of these development directions and comprises a collection of review papers and a research article authored by renowned researchers actively involved in this field. The topics covered by the review papers are photoredox-catalyzed reactions of imines, asymmetric catalytic electrosynthesis, cooperative catalysis of chiral N-heterocyclic carbenes and Lewis acid, and asymmetric ring-opening reactions of epoxides catalyzed by metal–salen complexes. The research article presents a proline-catalyzed aldol reaction in water–methanol solvent mixture.
Author: Thomas C. Nugent
Publisher: John Wiley & Sons
ISBN: 9783527629558
Category : Science
Languages : en
Pages : 520
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Book Description
This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a "Who's Who" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods. Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.
Author:
Publisher: Newnes
ISBN: 008097743X
Category : Science
Languages : en
Pages : 9815
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Book Description
The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
