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Author: Thomas W. O'Gorman
Publisher: SIAM
ISBN: 0898715539
Category : Mathematics
Languages : en
Pages : 180
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Book Description
Introduces many of the practical adaptive statistical methods and provides a comprehensive approach to tests of significance and confidence intervals.
Author: Thomas W. O'Gorman
Publisher: SIAM
ISBN: 0898715539
Category : Mathematics
Languages : en
Pages : 180
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Book Description
Introduces many of the practical adaptive statistical methods and provides a comprehensive approach to tests of significance and confidence intervals.
Author: Scott M. Berry
Publisher: CRC Press
ISBN: 1439825513
Category : Mathematics
Languages : en
Pages : 316
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Book Description
Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti
Author: Anthony C Atkinson
Publisher: CRC Press
ISBN: 1584886935
Category : Mathematics
Languages : en
Pages : 341
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Book Description
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
Author: David D. Hanagal
Publisher: Springer Nature
ISBN: 9811679320
Category : Mathematics
Languages : en
Pages : 318
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Book Description
This book collects select contributions presented at the International Conference on Importance of Statistics in Global Emerging (ISGES 2020) held at the Department of Mathematics and Statistics, University of Pune, Maharashtra, India, from 2–4 January 2020. It discusses recent developments in several areas of statistics with applications of a wide range of key topics, including small area estimation techniques, Bayesian models for small areas, ranked set sampling, fuzzy supply chain, probabilistic supply chain models, dynamic Gaussian process models, grey relational analysis and multi-item inventory models, and more. The possible use of other models, including generalized Lindley shared frailty models, Benktander Gibrat risk model, decision-consistent randomization method for SMART designs and different reliability models are also discussed. This book includes detailed worked examples and case studies that illustrate the applications of recently developed statistical methods, making it a valuable resource for applied statisticians, students, research project leaders and practitioners from various marginal disciplines and interdisciplinary research.
Author: Thomas Hill
Publisher: StatSoft, Inc.
ISBN: 9781884233593
Category : Mathematics
Languages : en
Pages : 854
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Book Description
This - one of a kind - book offers a comprehensive, almost encyclopedic presentation of statistical methods and analytic approaches used in science, industry, business, and data mining, written from the perspective of the real-life practitioner ("consumer") of these methods.
Author: Michael R. Kosorok
Publisher: SIAM
ISBN: 1611974186
Category : Medical
Languages : en
Pages : 348
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Book Description
Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine. The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.
Author: Shein-Chung Chow
Publisher: CRC Press
ISBN: 1439839883
Category : Mathematics
Languages : en
Pages : 368
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Book Description
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini
Author: David Pollard
Publisher: Springer Science & Business Media
ISBN: 1461218802
Category : Mathematics
Languages : en
Pages : 456
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Book Description
Contributed in honour of Lucien Le Cam on the occasion of his 70th birthday, the papers reflect the immense influence that his work has had on modern statistics. They include discussions of his seminal ideas, historical perspectives, and contributions to current research - spanning two centuries with a new translation of a paper of Daniel Bernoulli. The volume begins with a paper by Aalen, which describes Le Cams role in the founding of the martingale analysis of point processes, and ends with one by Yu, exploring the position of just one of Le Cams ideas in modern semiparametric theory. The other 27 papers touch on areas such as local asymptotic normality, contiguity, efficiency, admissibility, minimaxity, empirical process theory, and biological medical, and meteorological applications - where Le Cams insights have laid the foundations for new theories.
Author: Jay Bartroff
Publisher: Springer Science & Business Media
ISBN: 1461461146
Category : Medical
Languages : en
Pages : 250
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Book Description
Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information. Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.
Author: Yadolah Dodge
Publisher: Springer Science & Business Media
ISBN: 1441987665
Category : Mathematics
Languages : en
Pages : 188
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Book Description
While there have been a large number of estimation methods proposed and developed for linear regression, none has proved good for all purposes. This text focuses on the construction of an adaptive combination of two estimation methods so as to help users make an objective choice and combine the desirable properties of two estimators.
