Antigenic Variation

Antigenic Variation PDF Author: Alister G. Craig
Publisher: Elsevier
ISBN: 0080475884
Category : Medical
Languages : en
Pages : 461

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Book Description
The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.Comprehensive coverage of antigenic variation from viruses to parasitesDiscussions devoted to molecular mechanisms of host evasionDetailed descriptions of host/pathogen interactions

Antigenic Variation

Antigenic Variation PDF Author: Alister G. Craig
Publisher: Elsevier
ISBN: 0080475884
Category : Medical
Languages : en
Pages : 461

Get Book Here

Book Description
The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.Comprehensive coverage of antigenic variation from viruses to parasitesDiscussions devoted to molecular mechanisms of host evasionDetailed descriptions of host/pathogen interactions

Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations

Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations PDF Author: Ellen Hsu
Publisher: Springer
ISBN: 3319208195
Category : Medical
Languages : en
Pages : 340

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Book Description
This volume provides in-depth reviews of model systems that exemplify the arms race in host-pathogen interactions. Somatic adaptations are responsible for the individualization of biological responses to the environment, and the continual struggle between host immune systems and invading pathogens has given rise to corresponding processes that produce molecular variation. Whether in mollusks or human beings, various host somatic mechanisms have evolved independently, providing responses to counter rapidly-changing pathogens. The pathways they utilize can include non-heritable changes involving RNA and post-translational modifications, or changes that produce somatic DNA recombination and mutation. For infectious organisms such as protozoans and flatworms, antigenic variation is central to their survival strategy. Evolving the ability to evade the host immune system not only increases their chances of survival but is also necessary for successful re-infection within the host population.

Avian Influenza Virus

Avian Influenza Virus PDF Author: Erica Spackman
Publisher: Springer Science & Business Media
ISBN: 1588299392
Category : Technology & Engineering
Languages : en
Pages : 147

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Book Description
With the growing global fear of a major pandemic, avian influenza (AI) virus research has greatly increased in importance. In Avian Influenza Virus, an expert team of researchers and diagnosticians examine the fundamental, yet essential, virological methods for AI virus research and diagnostics as well as some of the newest molecular procedures currently used for basic and applied research. They present exciting, cutting-edge new methods that focus both on studying the virus itself and on work with avian hosts, an area greatly lacking in research.

Virus as Populations

Virus as Populations PDF Author: Esteban Domingo
Publisher: Academic Press
ISBN: 0128163321
Category : Science
Languages : en
Pages : 428

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Book Description
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes

Virus Taxonomy

Virus Taxonomy PDF Author:
Publisher:
ISBN: 9780122499517
Category : Viruses
Languages : en
Pages : 1259

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Book Description
Part I: Introduction to Universal Virus Taxonomy. Part II: The Viruses. A Glossary of Abbreviations and Terms. Taxa Listed by Nucleic Acid and Size of the Genome. The Virus Diagrams. The Virus Particle Structures. The Order of Presentation of the Viruses. The Double Stranded DNA Viruses. The Single Stranded DNA Viruses. The DNA and RNA Reverse Transcribing Viruses. The Double Stranded RNA Viruses. The Negative Sense Single Stranded RNA Viruses. The Positive Sense Single Stranded RNA Viruses. The Unassigned Viruses. The Subviral Agents. Viroids. Satellites. Vertebrate Prions. Fungal Prions. Part III: The International Committee on Taxonomy of Viruses. Officers and Members of the ICTV, 1999-2002. The Statutes of the ICTV, 1998. The Code of Virus Classification and Nomenclature,1998. Part IV: Indexs. Virus Indexs. Taxonomic Index.

The Dynamic Bacterial Genome

The Dynamic Bacterial Genome PDF Author: Peter Mullany
Publisher: Cambridge University Press
ISBN: 9780521821575
Category : Medical
Languages : en
Pages : 452

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Book Description
"This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. Because genome rearrangements are so important in evolution, at least one of the chapters views the phenomenon from an evolutionary angle. This book provides the reader with a holistic view of genome rearrangements (i.e., studies on both the biological consequences of genome rearrangement and the mechanisms underlying these processes are presented)." "The book is written by leading research workers in the field and is aimed at final-year undergraduates, postgraduate and postdoctoral workers, and established biologists."--BOOK JACKET.

Janeway's Immunobiology

Janeway's Immunobiology PDF Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :

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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Immunology and Evolution of Infectious Disease

Immunology and Evolution of Infectious Disease PDF Author: Steven A. Frank
Publisher: Princeton University Press
ISBN: 9780691095950
Category : Medical
Languages : en
Pages : 364

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Book Description
Publisher Description

Molecular and Cell Biology of Sexually Transmitted Diseases

Molecular and Cell Biology of Sexually Transmitted Diseases PDF Author: D.J. Wright
Publisher: Springer Science & Business Media
ISBN: 9401123845
Category : Science
Languages : en
Pages : 335

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Book Description
Molecular and Cell Biology of Human Diseases reviews the status of research on a range of sexually transmitted diseases whose incidence has paralleled the increase in HIV infection and examines the ways in which new methods are influencing current practice and are likely to shape future management.

Protozoa and Human Disease

Protozoa and Human Disease PDF Author: Mark F Wiser
Publisher: Garland Science
ISBN: 1136738169
Category : Medical
Languages : en
Pages : 255

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Book Description
Protozoa and Human Disease is a textbook on medically important protozoa and the diseases they cause for advanced undergraduate students, graduate students, and professionals. It combines a taxonomic and medical approach and is therefore suitable for a parasitology, microbiology, medical, and public health readership. In addition to the basics such as morphological features, life cycles, and the clinical manifestations of the diseases, topics like the molecular and immunological basis of pathogenesis, metabolic pathways, specialized subcellular structures, ecology of disease transmission, antigenic variation, and molecular epidemiology are discussed for many of the protozoan pathogens. At the end of the book is an extensive glos