Antibody-mediated autoimmune diseases of the CNS: Challenges and approaches to diagnosis and management PDF Download
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Author: Mei-Ping Ding
Publisher: Frontiers Media SA
ISBN: 288974745X
Category : Medical
Languages : en
Pages : 359
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Book Description
Author: Mei-Ping Ding
Publisher: Frontiers Media SA
ISBN: 288974745X
Category : Medical
Languages : en
Pages : 359
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Book Description
Author: Bernadete Liphaus
Publisher: Frontiers Media SA
ISBN: 2832557317
Category : Medical
Languages : en
Pages : 271
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Book Description
Autoimmune diseases are characterized by immune dysregulation, leading to immune-mediated damage of healthy tissues and cells. Despite increasing research, the exact cause of individual autoimmune disorders is not yet entirely understood. Pediatric autoimmune diseases, in particular, are often less extensively studied and present their own challenges to physicians in terms of diagnosis, as well as their treatment, often requiring a multidisciplinary approach. Understanding how autoimmune responses initiate and progress will allow us to develop novel therapeutics and improve disease management strategies. Inborn errors of immunity (IEI) are genetic disorders that have recently been linked to a series of early-onset autoimmune disorders. An example is the LRBA deficiency which may manifest as a series of autoimmune diseases, including inflammatory bowel disease, endocrinopathies, autoimmune hemolytic anemia, thrombocytopenia, arthritis, and SLE. The IEI may also manifest as increased susceptibility to infections, autoinflammatory, allergic, and/or malignant diseases, however, there are few IEI in which an autoimmune manifestation has never been observed.
Author: Mahbuba Rahman
Publisher: Academic Press
ISBN: 0323913792
Category : Science
Languages : en
Pages : 348
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Book Description
Metabolomics: A Path Towards Personalized Medicine integrates environmental factors of genomics, transcriptomics and proteomics, providing a bridge to resolve gaps between fundamental science and applications in clinical medicine and population health. The concept of personalized medicine or precision medicine is of great interest in biomedical research as it helps bring about new drug discovery and biomarker identification. In addition, it helps clinicians prescribe the right medicine to the right person with maximum efficacy and minimum toxicity, allowing clinicians to further predict the susceptibility to disease onset of vulnerable populations.The book is ideally suited for researchers and postgraduate students who are interested in clinical and non-clinical studies where metabolites are used for the identification of disease and therapeutic targets. - Gives insights on the importance of personalized medicine in clinical and research environments - Provides the principles of metabolomics - Presents applications of metabolomics in biomarker identification and drug discovery
Author: Yinghong Wang
Publisher: Springer Nature
ISBN: 3031002415
Category : Medical
Languages : en
Pages : 333
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Book Description
Certain organ toxicities can be severe and life-threatening. Therefore, it is crucial to recognize these disease entities early on to provide prompt and effective treatments to improve the quality of patient care, and enable the continuation of cancer therapy long-term. A clinical handbook with a particular focus in this field is lacking. This handbook focuses on the comprehensive, systematic review of clinical aspects of immunotherapy-induced toxicities in 15 major organ systems. The organs covered include endocrine, eye, gut, heart, kidney, liver, lung, muscular-skeletal, neuro, pancreas and skin etc. A unique feature about this book is the inclusion of perspectives from Anesthesiology, Infectious Disease, and Pathology besides specific organ toxicity management. The contributors are a group of experts offering routine clinical care to patients with most complex and refractory toxicity conditions, conducting pioneering research, and providing the guidance for the clinical practice to the peers and trainees in the field. The topics of each chapter include incidence, clinical presentations, evaluation, management, and long term follow up of each disease entity. There is also a simplified management algorithm or table illustrated in each chapter as well as audio PowerPoint slide deck to provide straightforward general instruction on the evaluation and treatment.
Author: Robert Weissert
Publisher: Frontiers Media SA
ISBN: 2889767442
Category : Medical
Languages : en
Pages : 160
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Book Description
Author: Alberta Hoi
Publisher: Springer Nature
ISBN: 3030851613
Category : Medical
Languages : en
Pages : 192
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Book Description
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Author: Renzo Guerrini
Publisher: Cambridge University Press
ISBN: 9780521771108
Category : Medical
Languages : en
Pages : 598
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Book Description
The boundaries between epilepsy and movement disorders are difficult to define; some syndromes or diseases may combine the two and many manifestations of one are similar to the other. For the first time, a distinguished, international team of specialists comprehensively examines the clinical, neurophysiological, genetic, pharmacological and molecular factors which underlie the relationships and differences between the two disorders. They examine the methods for investigating motor cortex excitability and the electrophysiological and chemical characteristics of epilepsies which resemble movement disorders. They present a scheme for neurophysiological classification of myoclonic epilepsies and myoclonus and give a detailed analysis of the disorders which cause diagnostic problems in children and adults. There is also an innovative, up-to-date review of the genetic syndromes which associate epilepsy and paroxysmal dyskinesias, and a review of the drugs used to treat, or which may precipitate, epilepsy and movement disorders. This is essential reading for clinicians and neuroscientists.
Author: Yu Cai
Publisher: Frontiers Media SA
ISBN: 2832501753
Category : Medical
Languages : en
Pages : 203
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Book Description
Author:
Publisher: Elsevier
ISBN: 0444634460
Category : Medical
Languages : en
Pages : 569
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Book Description
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Author: Yehuda Shoenfeld
Publisher: Springer Science & Business Media
ISBN: 1603272852
Category : Medical
Languages : en
Pages : 555
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Book Description
According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.
