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Author: Malcolm Whitman
Publisher: CRC Press
ISBN: 1420004786
Category : Science
Languages : en
Pages : 458
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Book Description
Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in embryos. Focusing on specific pathways or pathway comp
Author: Malcolm Whitman
Publisher: CRC Press
ISBN: 1420004786
Category : Science
Languages : en
Pages : 458
Get Book
Book Description
Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in embryos. Focusing on specific pathways or pathway comp
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2008
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Andrew Baird
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 542
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Book Description
Author: Paul T. Sharpe
Publisher: Springer Science & Business Media
ISBN: 1592592708
Category : Science
Languages : en
Pages : 752
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Book Description
Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.
Author: Horst Grunz
Publisher: Springer Science & Business Media
ISBN: 9783540140320
Category : Medical
Languages : en
Pages : 456
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Book Description
The organizer area plays a central role in the formation of the embryonic axis and the central nervous system of all vertebrates including the human fetus. In The Vertebrate Organizer outstanding molecular development biologists and embryologists report their latest approaches in this fascinating research area using different vertebrate model organisms. The presented data are of central importance for the understanding of early human embryogenesis.
Author: Sarah L. Tulin
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 0
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Book Description
The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease. A current challenge is to understand the mechanisms used by this signaling pathway to accomplish its myriad tasks in patterning the embryo, forming organs, and maintaining systems in the adult animal. My thesis work has focused on tackling this challenge in the model system of Drosophila melanogastor, the vinegar fly. By examining functional domains of Thisbe and Pyramus, FGF ligands in the fly, we have begun to understand the properties of Drosophila FGFs and the way in which they may contribute to regulation of FGF signaling. FGF ligands in vertebrates are small molecules that bind to a corresponding receptor through two immunoglobulin domains. The FGF ligands in Drosophila are predicted to be much larger molecules than their vertebrate homologs. Whether Drosophila FGFs bind to the receptor as full-length proteins or are first cleaved to smaller molecules was previously unknown. My thesis work addressed this question through experiments in Drosophila embryos and Drosophila cell culture. I found evidence that the N-terminal FGF-domain alone is capable of signaling by itself in the embryo. In addition, experiments in cell culture showed that Thisbe and Pyramus are secreted as small forms, presumably as a result of intracellular proteolytic cleavage. Cleaved forms for Thisbe and Pyramus were detected in embryonic extracts as well. The Ths ligand is also present outside the cell as a full-length form and this form may act to regulate the diffusion or activity of the ligand. Addition of the Thisbe C-terminus to the Pyramus N-terminus to make a Pyramus-Thisbe chimeric protein creates a protein that has reduced activity compared to Thisbe alone. The opposite Thisbe-Pyramus chimera creates a protein that has increased activity compared to Ths alone. Over the course of animal evolution the FGF superfamily has diversified in many ways. Understanding the mechanism of FGF signaling in Drosophila and comparing this to other Drosophilids, insects, and more distantly related animals will reveal the likely makeup of the ancestral FGF signaling system.
Author: Sarah L. Tulin
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 286
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Book Description
The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease. A current challenge is to understand the mechanisms used by this signaling pathway to accomplish its myriad tasks in patterning the embryo, forming organs, and maintaining systems in the adult animal. My thesis work has focused on tackling this challenge in the model system of Drosophila melanogastor, the vinegar fly. By examining functional domains of Thisbe and Pyramus, FGF ligands in the fly, we have begun to understand the properties of Drosophila FGFs and the way in which they may contribute to regulation of FGF signaling. FGF ligands in vertebrates are small molecules that bind to a corresponding receptor through two immunoglobulin domains. The FGF ligands in Drosophila are predicted to be much larger molecules than their vertebrate homologs. Whether Drosophila FGFs bind to the receptor as full-length proteins or are first cleaved to smaller molecules was previously unknown. My thesis work addressed this question through experiments in Drosophila embryos and Drosophila cell culture. I found evidence that the N-terminal FGF-domain alone is capable of signaling by itself in the embryo. In addition, experiments in cell culture showed that Thisbe and Pyramus are secreted as small forms, presumably as a result of intracellular proteolytic cleavage. Cleaved forms for Thisbe and Pyramus were detected in embryonic extracts as well. The Ths ligand is also present outside the cell as a full-length form and this form may act to regulate the diffusion or activity of the ligand. Addition of the Thisbe C-terminus to the Pyramus N-terminus to make a Pyramus-Thisbe chimeric protein creates a protein that has reduced activity compared to Thisbe alone. The opposite Thisbe-Pyramus chimera creates a protein that has increased activity compared to Ths alone. Over the course of animal evolution the FGF superfamily has diversified in many ways. Understanding the mechanism of FGF signaling in Drosophila and comparing this to other Drosophilids, insects, and more distantly related animals will reveal the likely makeup of the ancestral FGF signaling system.
Author: Society for Developmental Biology. Symposium
Publisher: New York : A.R. Liss
ISBN: 9780845115046
Category : Science
Languages : en
Pages : 188
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Book Description
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309170427
Category : Science
Languages : en
Pages : 112
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Book Description
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Author: David J. Kerr
Publisher: Oxford University Press
ISBN: 0191065110
Category : Medical
Languages : en
Pages : 2837
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Book Description
Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.
