Analysis of Gene Amplification in Human Cancer PDF Download
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Author: Thomas Santarius
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Thomas Santarius
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Kenneth Wayne Kinzler
Publisher:
ISBN:
Category :
Languages : en
Pages : 186
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Book Description
Author: Anna Walentinsson
Publisher:
ISBN:
Category : Gene amplification
Languages : en
Pages : 170
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Book Description
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2004
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Takis S. Papas
Publisher: Elsevier Publishing Company
ISBN: 9780444011169
Category : Medical
Languages : en
Pages : 320
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Book Description
Oncogenes were first discovered as part of the genome of acute transforming retroviruses. This comprehensive and timely work furthers our understanding of the genetic makeup and mechanism of action of oncogenes. The fourth volume in a series that conveys vital information to scientists working in recombinant genetics and molecular biology, Oncogenes brings together recent findings derived from DNA transfection and transformation assays. International contributors analyze and assess oncogenes from a variety of perspectives to present the latest knowledge. Providing useful information on a topic vital to today's research in molecular oncology, Oncogenes is a valuable update for all those working in the field of genetic engineering.
Author: Kenneth W. Kinzler
Publisher: McGraw-Hill Professional Publishing
ISBN:
Category : Health & Fitness
Languages : en
Pages : 854
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Book Description
-- Current coverage of diagnosis and treatment on a wide spectrum of active cancer research.
Author: William B. Coleman
Publisher: Springer Science & Business Media
ISBN: 1592591256
Category : Medical
Languages : en
Pages : 580
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Book Description
Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.
Author: R.S. Verma
Publisher: Elsevier
ISBN: 0080526160
Category : Medical
Languages : en
Pages : 233
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Book Description
The underlying idea that cancer is a genetic disease at the cellular level was postulated over 75 years ago when Boveri hypothesised that the malignant cell was one that had obtained an abnormal chromatin content. However, it has been only the last decade where enormous strides have been made toward understanding neoplastic development. Explosive growth in the discipline of cancer genetics is so rapid that any attempt to review this subject becomes rapidly outdated and continuous revisions are warranted. Conclusive evidence has been reached associating specific chromosomal abnormalities to various cancers. We have just begun to characterise the genes, which are involved in these consistent chromosomal rearrangements resulting in the elucidation of the mechanisms of neoplastic transformation at a molecular level. The identification of over 50 oncogenes has led to a better understanding of the physiological process. Tumor suppresser genes, which were discovered through inheritance mechanisms, have further shed some light towards understanding the loss of heterozygosity during carcinogenesis. The message emerging with increasing clarity concerning specific pathways which regulate the fundamental process of cell division and uncontrolled growth. The advances in molecular biology have led to a major insight in establishing precise diagnosis and treatment of many cancers resulting in prevention of death. The field is expanding so rapidly that a complete account of all aspects of genetics of cancer could not be accommodated within the scope of a single volume format. Nevertheless, a few very specific topics have been chosen, which readers may find of great interest in hopes that their interest may be rejuvenated concerning the bewildering nature of this deadly disease. The contributors to Volume 3 have provided up-to-date accounts of their fields of expertise. Although the contributors have kept their chapters brief, they include an extensive bibliography for those who wish to understand a particular topic in depth. For more than a century, cancer has been diagnosed on the enigmatic basis of morphological features. Establishing a diagnosis based on DNA, RNA, and proteins, which is done routinely now, was once inconceivable. Cloning a gene of hematopoietic origin is no longer a fantasy. The approach has shifted over the past 15 years from identification of chromosomal abnormalities toward zeroing in on cancer genes.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 8
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Cancer is a disorder brought upon by the accumulation of specific mutations in the cancerous cells. Our understanding of the disease, and potentially its diagnosis and therapeutic treatment, is enhanced by defining the genetic lesions that cause it. Representational difference analysis, or RDA, was developed to do just this. RDA is a DNA subtraction methodology that finds sequences present in one DNA population, the tester, that is absent or reduced in a second, the driver (1, 2). RDA has been used to discover sequences lost or amplified in the genomic DNA of the cancerous cells (3). Genetic loss and gene amplification are hallmarks of tumor suppressor genes and oncogenes, respectively. We have been applying RDA to the discovery of sequences lost in breast cancer. At least three loci undergoing loss in breast cancer have been identified. The transcriptional potential of these loci is being explored. Characterization of many other RDA probes is in progress. We expect that the continued execution of our stated plan will accomplish our stated goal, the identification of tumor suppressor genes that are commonly involved in breast cancer.
