An Investigation Into the Mechanics of Dynamic Compaction of Pharmaceutical Powders PDF Download
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Author: M. H. A. Es-Saheb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: M. H. A. Es-Saheb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Mahir Hamdi Hamed Es-Saheb
Publisher:
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Category :
Languages : en
Pages :
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Author: Saurabh M. Mishra
Publisher:
ISBN:
Category :
Languages : en
Pages : 426
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Pharmaceutical product development has evolved from conventional empirical approach towards the more systematic and science based approach over the past decades. However, the process of tableting and compaction behavior of pharmaceutical powders is still ambiguous and not well understood. In the present study, a comprehensive attempt has been made to understand this complex and dynamic process of compaction of disordered pharmaceutical powders using percolation phenomenon. Commonly used pharmaceutical powder materials, spheres and their binary mixtures of different particle sizes, crystal structure and deformation behavior were compressed at varying compression loads at different relative densities. Mechanical strength of tablets, namely radial tensile strength, compressive strength and elastic modulus, were evaluated and studied according to the classical models of powder compaction and percolation phenomenon. It was found that percolation phenomenon has a significant effect on the compaction of powder materials and can be used to characterize deformation and bonding behavior of powder materials. A model developed on the fundamentals of percolation theory was found to predict the compactibility of disordered powder materials and their binary mixtures with higher accuracy compared to the established classical compaction models. Moreover, it was found that the developed model can predict the dilution capacity of excipients and can be used as a material-sparing tool in the initial formulation development of tablet dosage forms. It was also found that percolation theory can help to understand mechanics of tablet formation more clearly by establishing a relationship between compressibility and compactibility phenomena of powder materials. Further, a closer look at tableting process reveals that process of tableting closely mimics 3-dimensional correlated diffusive percolation phenomenon with a universal critical exponent value of q = 2 and percolation thresholds, Ï1c = 0.634 (z = 12) and 0.366 (z = 6) depending on the type of material used. Similar results were also observed in the case of powders compacted using an industrial scale rotary tablet press thus confirming that tableting of pharmaceutical powders is far from an equilibrium process depending upon the variability of time and space. Thus it can be concluded that comprehensive application of percolation theory can serve as a single effective tool in the study of compaction behavior of pharmaceutical powders and can be effectively used in the current quality by design (QbD) practice to establish robust design space for the formulation development of tablet dosage forms.
Author: D. C. Barton
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Category :
Languages : en
Pages :
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Author:
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Category : Powder metallurgy
Languages : en
Pages : 578
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Author: D. C. Barton
Publisher:
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Category :
Languages : en
Pages : 134
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Author: Metin Çelik
Publisher: CRC Press
ISBN: 1420089188
Category : Medical
Languages : en
Pages : 360
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Book Description
Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,
Author: B. J. Briscoe
Publisher: CRC Press
ISBN:
Category : Art
Languages : en
Pages : 504
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Book Description
These proceedings represent a new approach to powder technology in which tribological principles are introduced and the common interest of tribologists and particle technologists is clearly stated for the first time.
Author: Yihong Qiu
Publisher: Academic Press
ISBN: 0128026375
Category : Medical
Languages : en
Pages : 1178
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Book Description
Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives
Author: Vonne D. Linse
Publisher:
ISBN:
Category :
Languages : en
Pages : 104
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Book Description
The state of the art and the technological potential for the dynamic consolidation of metal and ceramic powders were assessed. Fundamental consideration of dynamic consolidation, consolidation phenomena during dynamic compaction, dynamic compaction and conditioning of metal and ceramic powders, characterization of dynamically consolidated metal and ceramic powders, computer codes applicable to dynamic compaction, practical and potential applications, problem areas, and the current position of the United States in dynamic compaction were examined. Based on its conclusions, the committee recommend that a systematic study of the dynamic compaction process should be conducted; existing techniques should be improved and new ones developed for monitoring of dynamic events as close to the microscale as possible for temperatures, shock velocities, pressures and particle motion data from systematic experiments should be utilized to form data information for modeling codes; coordination among those investigating dynamic compaction should be maintained; a sufficiently funded, sustained, coordinated, and concentrated research and development effort should be initiated to strengthen the United States position in the dynamic compaction field. (Author).
