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Author: Meli George
Publisher:
ISBN: 9781910664018
Category : Camp sites, facilities, etc
Languages : en
Pages : 302
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Book Description
Author: Meli George
Publisher:
ISBN: 9781910664018
Category : Camp sites, facilities, etc
Languages : en
Pages : 302
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Book Description
Author: Corey Taylor
Publisher: Yorkshire Publishing
ISBN: 9780881443486
Category :
Languages : en
Pages : 166
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Book Description
What if you had everything as a child and life seemed perfect.Your family has money; in fact you live in one of the biggest houses on the block. Now imagine you are suddenly thrust into a life of poverty and lack. Undoubtedly, middle class and poor people have heard a similar story like this or lived this experience first hand. Most have dreamed of their lives somehow magically ending in a Rags to Riches type story. However, far too often people dreams become crush by the weight of realistic living and soon they give up. If this sounds like you or someone you know then it is time to stop allowing your dreams to be crushed. The Other 'Aire provides a fresh and new perspective on the class system of society. Prepare for your life and finances to be transformed by The Other 'Aire.
Author: Mitsuru Matsumoto
Publisher: Springer Nature
ISBN: 981999781X
Category :
Languages : en
Pages : 252
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Book Description
Author: VICARIOUS BOOKS MEDIA.
Publisher:
ISBN: 9781910664063
Category : Belgium
Languages : en
Pages : 224
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Book Description
Author: Gustavo Wilches-Chaux
Publisher: Villegas Asociados
ISBN: 9589138888
Category : Colombia
Languages : en
Pages : 202
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Book Description
Seen from above, from the sky, a country's geography looks like it really is: a huge living individual organism that has nothing to do with a mound of amorphous geography. Rivers that run like veins over valleys and mountians are a sight of majestic vitality; mountain chains as gigantic arms emerging from thick jungles and forests, extended through the land as vitaloxigen suppliers. This is Colombia seen from the air An hallucinating tour through the landscape of a country where one can breathe, touch and see exuberance, where the shiny silver rivers of the Caribbean plains glow while the high-tide of the deep Pacific Coast announces the arrival of whales to the Continent. A paradise where the coffee growing area spreads out like aninmense quilt, sewn in green over the mountains, and moors host lakes of multi-coloured waters and unique species. Colombia from the air is the perfect book to cherish and be dazzled by the irresistible beauty that comes from the earth and the sea, fading in the horizon.
Author: Ireland
Publisher:
ISBN:
Category : Irish language
Languages : en
Pages : 622
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Book Description
Author: Eoin Mac Neill
Publisher:
ISBN:
Category : Law
Languages : en
Pages : 64
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Book Description
Author:
Publisher: ScholarlyEditions
ISBN: 1464924139
Category : Medical
Languages : en
Pages : 218
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Book Description
Basic Amino Acids: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Basic Amino Acids. The editors have built Basic Amino Acids: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Basic Amino Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Basic Amino Acids: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Claudio Pignata
Publisher: Frontiers Media SA
ISBN: 2889197174
Category : Immunologic diseases. Allergy
Languages : en
Pages : 83
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Book Description
The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterations of genes, involved in the differentiation and functionality of the stromal component of the thymus, may lead to a severe T-cell defect or failure of central tolerance, as well. The first example of severe combined immunodeficiency (SCID) not related to an intrinsic alteration of the hematopoietic cell but rather of the thymic epithelial component is the Nude/SCID phenotype, inherited as an autosomal recessive disorder, whose hallmarks are the T-cell defect and the absence of the thymus. The clinical and immunological phenotype is the human equivalent of the murine Nude/SCID syndrome, which represents the first spontaneous SCID identified in nude mice in 1966. For over 3 decades studies of immune system in these mice enormously contributed to the overall knowledge of cell mediated immunity, in the assumption that the athymia of these mice was solely responsible for the T-cell immunological defect. This syndrome is due to mutations of the transcription factor FOXN1, belonging to the forkhead-box gene family, which is mainly expressed in the thymus and skin epithelial cells, where it plays a critical role in differentiation and survival. An alteration of the thymic structure is also a feature of the DiGeorge syndrome (DGS), which has been long considered the human counterpart of the nude mice phenotype. This syndrome is frequently associated to a deletion of the 22q11 region, which contains approximately 30 genes, including the TBX1 gene, which is responsible for most of the clinical features of DGS in humans and mice. In this syndrome common manifestations are cardiac malformations, speech delay, hypoparathyrodism and immunodeficiency, even though the immunological hallmarks of the T-cell defect in DiGeorge syndrome are profoundly different from those reported in human Nude/SCID. The divergence of the phenotype among these 2 entities raised the possibility that the FOXN1 transcription factor represents the real key stromal molecule implicated in directing the hematopoietic stem cell toward a proper T-cell fate. Thymic stromal component of the primary lymphoid organ is also required to negatively select the autoreactive clones, a process driven by the expression of tissue specific antigens (TSA) by medullary thymic epithelial cells (mTECs). The expression of genes encoding TSA antigens is mediated by autoimmune regulator (AIRE) gene, encoding a transcription factor expressed in mTECs. Molecular alterations of this gene are associated to autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), a rare autosomal disorder, which may be considered the prototype of an autoimmune disease due to the failure of central tolerance homeostasis. All these "experiments of nature" led to unravel novel pathogenic mechanisms underlying inherited disorders of immune system and, of note, to clarify the pivotal role of epithelial cells in the maturation and education process of T-cell precursors.
Author:
Publisher: Soffer Publishing
ISBN: 8203376770
Category :
Languages : en
Pages : 93
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Book Description
