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Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027308
Category : Medical
Languages : en
Pages : 208
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Book Description
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027308
Category : Medical
Languages : en
Pages : 208
Get Book Here
Book Description
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Author: Jonathan Sholl
Publisher: Springer Nature
ISBN: 3030526631
Category : Medical
Languages : en
Pages : 551
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Book Description
This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
Author: Carolyn M. Aldwin
Publisher: SAGE
ISBN: 9780761922599
Category : Social Science
Languages : en
Pages : 446
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Book Description
The authors undertake the difficult task of assembling an objective and holistic picture of human aging, including the physical aspects of aging, chronic disease and health promotion in the later years, for students and professionals.
Author: J. Robin Harris
Publisher: Springer
ISBN: 9811336814
Category : Medical
Languages : en
Pages : 499
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Book Description
This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.
Author: Nir Barzilai, M.D.
Publisher: St. Martin's Press
ISBN: 1250230861
Category : Health & Fitness
Languages : en
Pages : 320
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Book Description
How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.
Author: Andres Kriete
Publisher: Elsevier Inc. Chapters
ISBN: 0128070188
Category : Medical
Languages : en
Pages : 33
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Book Description
What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
Author: Robert Arking
Publisher: Oxford University Press
ISBN: 0195167392
Category : Family & Relationships
Languages : en
Pages : 619
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Book Description
Robert Arking's Biology of Aging is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging.
Author: Carolyn M. Aldwin
Publisher: SAGE Publications
ISBN: 1452266980
Category : Social Science
Languages : en
Pages : 441
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Book Description
FROM THE FOREWORD by James Birren: "Gaining understanding of aging is one of the most complex issues facing twenty-first century science. This book addresses the complexity of the factors that interact and influence the course of our longer life expectancy....How we humans grow old is a product of our genetic background as members of a species and our families. But the genome expresses itself in physical and social environments that modulate the appearance of heredity traits. In a sense aging is an ecological problem in which the dynamics are often difficult to explain....This book brings information from the sciences together in a way that is rarely done.....It provides an integration of knowledge about the dynamics of aging and can promote wisdom about how we can modify the life course to our advantage." In Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Carolyn M. Aldwin and Diane F. Gilmer undertake the challenging task of assembling an objective and holistic picture of human aging. The authors provide comprehensive, multidisciplinary coverage of the physical aspects of aging, including age-related changes and disease-related processes, the demography of the aging population, theories of aging, and the promotion of optimal aging. In addition, the book covers the psychosocial aspects of aging, including mental health, stress and coping, spirituality, and care giving in later years. Features of this book: Integrated. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Comprehensive. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Pedagogical. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data.Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Health, Illness and Optimal Aging is recommended for researchers seeking an overview of health psychology and aging, as well as undergraduate and graduate students taking classes in the social, behavioral, and health sciences. This text is also valuable for practitioners working with the elderly in fields such as nursing, social work, occupational and physical therapy, day-care and nursing home administration, psychology, and rehabilitation.
Author: Carolyn M. Aldwin
Publisher: Springer Publishing Company
ISBN: 0826193463
Category : Family & Relationships
Languages : en
Pages : 417
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Book Description
Print+CourseSmart
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
ISBN: 1441906398
Category : Medical
Languages : en
Pages : 462
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Book Description
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
