Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Pertussis and Rubella Vaccines PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309044995
Category : Medical
Languages : en
Pages : 382

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Book Description
Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura. The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.

Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Pertussis and Rubella Vaccines PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309044995
Category : Medical
Languages : en
Pages : 382

Get Book

Book Description
Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura. The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.

Adverse Effects of Aluminum

Adverse Effects of Aluminum PDF Author: Silas Jackson
Publisher:
ISBN:
Category : Aluminum
Languages : en
Pages : 36

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Book Description


Vaccines

Vaccines PDF Author: Paul A. Offit
Publisher: John Wiley & Sons
ISBN: 0471470325
Category : Health & Fitness
Languages : en
Pages : 257

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Book Description
Get the straight facts about vaccines and make informed choices Do you wonder whether vaccines are safe and whether they are all really necessary? This completely revised and updated edition of the classic Vaccines: What You Should Know helps you sort through the latest information about vaccines in order to determine what is right for your family. Coauthored by Paul Offit, a member of the CDC advisory committee that determines which vaccines are recommended for use in the United States, this guide tells you what vaccines are made of and clearly explains how they are made, how they work, and the risks associated with them. This updated edition includes recommendations for the smallpox vaccine, the latest information on vaccines for travelers, and the latest on the progress of combination vaccines. Expanded information on vaccine safety includes discussion of vaccines and autism, mercury in vaccines, and the ability of children to tolerate numerous vaccines at once.

Toxicological Risks of Selected Flame-Retardant Chemicals

Toxicological Risks of Selected Flame-Retardant Chemicals PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309171938
Category : Nature
Languages : en
Pages : 534

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Book Description
Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Neurotoxicity of Aluminum

Neurotoxicity of Aluminum PDF Author: Qiao Niu
Publisher: Springer Nature
ISBN: 9819915929
Category : Medical
Languages : en
Pages : 324

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Book Description
This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid beta—the pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment. The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.

Aluminium Toxicity in Infants' Health and Disease

Aluminium Toxicity in Infants' Health and Disease PDF Author: P F Zatta
Publisher: World Scientific
ISBN: 9814497975
Category : Medical
Languages : en
Pages : 260

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Book Description
Aluminium is the most abundant metal ion in the biosphere and we are continuously exposed to it in our everyday life through food, beverages, pharmaceutical products, etc. This book is a current and comprehensive review of the biochemistry, metabolism and toxicity of aluminium undertaken by an international group of authors, many of whom are outstanding authorities in their respective fields. In contrast with previous books on this topic, much of the subject matter is unique, in that it is primarily directed at aluminium nutrition and toxicity in infants and children. This book covers many aspects of aluminium toxicity in infants including for instance the embryo-fetal as well as the neurodevelopmental effects of this element, contamination of pharmaceutical products, and individual sensitivity through vaccines using aluminium as an adjuvant. This book will be especially useful to paediatricians, paediatric nephrologists & neurologists, nutritionists, toxicologists, biochemical toxicologists and postgraduate students. Contents:Chemistry, Biochemistry and Physiology:The Importance of Aluminium Chemistry in Biological Systems (R B Martin)Aluminium-26 as a Biological Tracer Using Accelerator Mass Spectrometry (R Flack & D Elmore)Aluminium Toxicity Depends on the Metal Speciation (P F Zatta & P Zambenedetti)Aluminium Metabolism (A C Alfrey)Aluminium and Iron Relationship: Pathophysiological and Clinical Overview (J B Cannata Andia)Pediatrics:Aluminium in Infancy (K Simmer)Aluminium Toxicity in Infants (M E McGraw)Aluminium-related Bone Disease in Children with Renal Failure (B D Kuizon & I B Salusky)Aluminium and Antacids in Infants (J W L Puntis)Development and Aluminium Experimental Toxicity (R L Domingo)Pediatric Pharmacology:Aluminium Content of Parenteral Nutrition Products (G L Klein)Aluminium-26 as a Biological Tracer Using Accelerator Mass Spectrometry (A Moreno et al.)Aluminium in Human Albumin Solutions (B Gammelgaard & O Jøns)Reduction of Aluminium Levels in Albumin Products (Y Uemura et al.)Toxicity of Aluminium Compounds as an Adjuvant for Vaccines (N Goto)A Public Health Analysis of Dietary Aluminium (S Humphreys & P M Bolger) Readership: Paediatricians, paediatric nephrologists & neurologists, nutritionists, toxicologists, biochemical toxicologists and postgraduate students. keywords:Aluminum;Alzheimer's Disease;Infants' Toxicity;Vaccines;Infants' Formula;Antiacids;Brain;Development and Aluminum;Bone Disease;Renal Failure “The simplicity and the accuracy with which the problem of aluminum toxicity is confronted in this book is enlightening and makes it a useful and indispensable tool on both pediatric and neonatology wards.” Biol Neonate

Pocket Companion to Brenner and Rector's The Kidney E-Book

Pocket Companion to Brenner and Rector's The Kidney E-Book PDF Author: Michael R. Clarkson
Publisher: Elsevier Health Sciences
ISBN: 1455703788
Category : Medical
Languages : en
Pages : 928

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Book Description
Pocket Companion to Brenner and Rector’s The Kidney distills the essential clinical information from the latest edition of the seminal text on kidney diseases and their management. Michael R. Clarkson, Ciara Magee, and Barry M. Brenner detail the key pathophysiologic, diagnostic, and treatment issues in clinical nephrology, including interventional nephrology, endocrine aspects of kidney disease, and plasmapheresis. Diagnose, treat, and manage both common and uncommon disorders. Find clinical knowledge quickly and easily thanks to convenient tables throughout the text. Choose the best option of the many techniques available through discussions of indications for laboratory tests and imaging studies. Enhance your clinical acumen with coverage of new topics such as risk factors and kidney disease, nephron endowment, interventional nephrology, plasmapheresis, xenotransplantation, stem cells in renal biology and medicine, and more. Stay current thanks to two new sections—Epidemiology and Risk Factors in Kidney Disease and Frontiers in Kidney Disease—that include topics such as stem cell and genomics.

Toxicological Profile for Aluminum

Toxicological Profile for Aluminum PDF Author:
Publisher:
ISBN:
Category : Aluminum
Languages : en
Pages : 296

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Book Description


Toxicological Profile for Aluminum and Compounds

Toxicological Profile for Aluminum and Compounds PDF Author:
Publisher:
ISBN:
Category : Aluminum
Languages : en
Pages : 168

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Book Description


Aluminium and Alzheimer's Disease

Aluminium and Alzheimer's Disease PDF Author: C. Exley
Publisher: Elsevier
ISBN: 0080525504
Category : Science
Languages : en
Pages : 453

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Book Description
The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease. This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.