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Author: Miao Yanfei
Publisher: Scientific Research Publishing, Inc. USA
ISBN: 1649971486
Category : Technology & Engineering
Languages : en
Pages : 179
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Book Description
Chemistry is a subject that makes human life better. In the past few hundred years, the development of modern chemistry has also explained this meaning perfectly. Naturally, supramolecular chemistry also needs to move from theory to application, from laboratory to society, and ultimately benefit mankind. Insoluble drugs refer to poorly water-soluble drugs, which will lead to difficult absorption and transportation in vivo and low bioavailability. About 40% of the newly discovered natural active substances and nearly 60% of the chemically synthesized drugs are insoluble drugs. Their solubility (in water) is poor and it is difficult to achieve satisfactory clinical efficacy, so they have not been successfully developed into new drugs. Natural β-cyclodextrin can form supramolecular inclusion complexes with insoluble drugs, thus increasing the solubility of insoluble drugs. As a new drug delivery carrier, it has been widely studied and applied. Sulfobutyl eth-er-β-cyclodextrin is a derivative of β-cyclodextrin. Because of its good water solubility and biocompatibility, sulfobutyl ether-β-cyclodextrin can sig-nificantly increase the solubility, bioavailability and low nephrotoxicity of drugs. As a new type of injection drug delivery carrier, it has become one of the hot spots in the research and development of new drugs at home and abroad.
Author: Miao Yanfei
Publisher: Scientific Research Publishing, Inc. USA
ISBN: 1649971486
Category : Technology & Engineering
Languages : en
Pages : 179
Get Book Here
Book Description
Chemistry is a subject that makes human life better. In the past few hundred years, the development of modern chemistry has also explained this meaning perfectly. Naturally, supramolecular chemistry also needs to move from theory to application, from laboratory to society, and ultimately benefit mankind. Insoluble drugs refer to poorly water-soluble drugs, which will lead to difficult absorption and transportation in vivo and low bioavailability. About 40% of the newly discovered natural active substances and nearly 60% of the chemically synthesized drugs are insoluble drugs. Their solubility (in water) is poor and it is difficult to achieve satisfactory clinical efficacy, so they have not been successfully developed into new drugs. Natural β-cyclodextrin can form supramolecular inclusion complexes with insoluble drugs, thus increasing the solubility of insoluble drugs. As a new drug delivery carrier, it has been widely studied and applied. Sulfobutyl eth-er-β-cyclodextrin is a derivative of β-cyclodextrin. Because of its good water solubility and biocompatibility, sulfobutyl ether-β-cyclodextrin can sig-nificantly increase the solubility, bioavailability and low nephrotoxicity of drugs. As a new type of injection drug delivery carrier, it has become one of the hot spots in the research and development of new drugs at home and abroad.
Author: J. Szejtli
Publisher: Springer Science & Business Media
ISBN: 9401577978
Category : Science
Languages : en
Pages : 459
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Book Description
Author: Wanda Sliwa
Publisher: John Wiley & Sons
ISBN: 3527339809
Category : Science
Languages : en
Pages : 334
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Book Description
Authored by two experts working in this important field of research, the timely book covers the latest advances in the synthesis of cyclodextrins, their properties and important industrial applications. To this end, the authors describe covalent and non-covalent assemblies, cyclodextrin inclusion complexes, cyclodextrin polymers, and modified cyclodextrins, resulting in an up-to-date overview of cyclodextrin chemistry. An invaluable reference for organic and polymer chemists in academia as well as those researchers in industry working in polymer, supramolecular and pharmaceutical chemistry, as well as food, textile and cosmetic science.
Author: Karl-Heinz Frömming
Publisher: Springer Science & Business Media
ISBN: 9401582777
Category : Medical
Languages : en
Pages : 248
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Book Description
Nearly three thousand papers and patents are dedicated to the actual or potential uses of cyclodextrins in pharmacy and pharmaceutical formulations. This is the first book written for pharmacists and pharmaceutical technologists which not only critically summarizes the enormous amount of literature available, but which can be used as a handbook when looking for solutions to practical problems. The fundamentals -- chemistry of cyclodextrins and their derivatives -- their physical and chemical properties are condensed to the most relevant items in Chapters 1 and 2. Chapter 3 deals with the adsorption, metabolism and toxicological properties of cyclodextrins. Chapter 4 explains the formulation, structure, composition and advantageous effects of the cyclodextrin inclusion complexes. Chapter 5 describes the methods for preparation and characterization of drug/cyclodextrin complexes. Chapters 6 and 7 are dedicated to the pharmacokinetics, biopharmaceutical and technological aspects of drug/CD complexes. Chapter 8 treats the application and effects of cyclodextrins in various drug formulations. The Appendix comprises a collection of recipes for any type of drug formulation. This book is aimed at those who use cyclodextrins in drug formulations, to improve the properties of existing drug formulations, or who want to prepare quite new formulations.
Author: J. Szejtli
Publisher: Springer Science & Business Media
ISBN: 9400926375
Category : Medical
Languages : en
Pages : 527
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Book Description
The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins. This Symposium - held in September 1981 in Budapest, with more than 200 participants from 17 countries - proved to be very succesfull in every respect, therefore it has been accepted unanimously to organize the lInd CD-Symposium in 1984, in Tokyo. (The Budapest-Symposium got posteriorly the "First" adjective). The IInd Symposium was held together with the III. Int. Symposium on Chlatrate Compounds and Molecular Inclusion Phenomena. The IIIrd CD-Symposium also was held as a Joint Symposium, with the IVth. Chlatrate Symposium in Lancaster, U. K. ,1986. The limited time however showed, that such a broad field - from calixarenes to zeolites - can not be managed efficiently. Therefore the International Organizing Committee voted for separation of two Symposia in the future. The IVth Int. CD-Symposium was held in the Munich, in April 1988, and the Vth Chlatrate Symposium (called already Vth Int. Symposium on Inclusion Phenomena and Molecular Recognition) was held in Alabama, Sept. 1988. In Munich 220 participants from 21 countries attended 32 verbal lectures and 54 posters. This volume contains the submitted 71 manuscripts of the IVth Cyclodextrin Symposium.
Author: J. Szejtli
Publisher: Springer Science & Business Media
ISBN: 9400978553
Category : Science
Languages : en
Pages : 522
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Book Description
Cyclodextrins are galnlng industrial interest owing to their particu lar structure. These cyclic amyloses are commonly composed of 6, 7 or 8 (named a-, 8-, y-CD) glucose units. They undergo complexation with quite a large number of substances by molecular inclusion. Their potential for in dustrial application is substantiated by their ability to protect fragile substances from oxygen and UV, to delay the evolution of volatiles and to aid the ancillary processing of dangerous or volatile substances in powder ed form. Though a-, 8- and y-CD exhibit different inclusion specificity, 8-CD has found more attention than the others. This is due to the fact that most of the cyclodextrin producing enzymes known produce predominantly 8-CD. Fur thermore 8-CD is by far the least soluble form, leading to a relatively sim ple production and purification. Consequently 8-CD is already in production on an industrial scale [~] while a- and 8-CD are still more or less re garded as specialities. A further CD-producing enzyme has been found in the medium of K. pneu moniae [l], Since this CGT appeared to produce predominantly a-CD [~], it has been chosen to develop a process for the production of a-CD. MATERIALS AND METHODS Analysis of cyclodextrins: HPLC on Lichrosorb-NH . 10 ~m, with acetonitrile 2 water 65/35 per volume. Test for CGT activity: as described by Landert elsewhere in this Volume. Starch: potato starch as obtained from Blattmann, Wadenswil, Switzerland.
Author: József Szejtli
Publisher:
ISBN:
Category : Cyclodextrins
Languages : en
Pages : 304
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Book Description
Author: Sophie Fourmentin
Publisher: Springer
ISBN: 3319761595
Category : Science
Languages : en
Pages : 262
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Book Description
This book is the first volume of two volumes on cyclodextrins published in the series Environmental Chemistry for a Sustainable World. After a brief description of the cyclodextrin fundamentals, the first chapter by Grégorio Crini et al. provides an overview of cyclodextrin research during the last 5 years. The second chapter by Michal Řezanka discusses the synthesis of novel cyclodextrin systems by selective modifications. Then Eric Monflier et al. describes the synthesis of nanostructured porous materials based on cyclodextrins, and applications in heterogeneous catalysis and photocatalysis. The use of thermal analyses for assessing cyclodextrin inclusion complexes is reviewed in chapter 4 by Daniel Hădărugă et al. Experimental methods for measuring binding constants of cyclodextrin inclusion compounds are presented by David Landy. The second volume reviews cyclodextrin applications in medicine, food, environment and liquid crystals.
Author:
Publisher: ScholarlyEditions
ISBN: 1464994048
Category : Medical
Languages : en
Pages : 410
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Book Description
Central Nervous System Agents—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Central Nervous System Agents. The editors have built Central Nervous System Agents—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Agents—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: J.L Atwood
Publisher: Springer
ISBN:
Category : Science
Languages : en
Pages : 954
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Book Description
Proceedings of the Third International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the Second International Symposium on Cyclodextrins, Tokyo, Japan, July 23-27, 1984
