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Author: Frederic Lamoth
Publisher: Frontiers Media SA
ISBN: 2889197891
Category : Aspergillus fumigatus
Languages : en
Pages : 111
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Book Description
Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborate mechanisms of adaptation to allow the initiation and progression of infection in the human host. The fungal cell wall, with its unique and dynamic structure, is responsible for protecting cell integrity and evading the host immune system, thus contributing to biofilm formation and virulence, and thus representing an ideal antifungal target. The emergence of azole resistance implies various and complex mechanisms that need to be further elucidated. Other important processes, such as biosynthetic pathways and toxin / metabolite production is important for fungal survival and propagation in the host environment, ultimately leading to disease. Moreover, the host immune response is a determinant factor in influencing the course of infection. The objective of this paper is to provide an overview of the pathogenesis to outline future research.
Author: Frederic Lamoth
Publisher: Frontiers Media SA
ISBN: 2889197891
Category : Aspergillus fumigatus
Languages : en
Pages : 111
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Book Description
Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborate mechanisms of adaptation to allow the initiation and progression of infection in the human host. The fungal cell wall, with its unique and dynamic structure, is responsible for protecting cell integrity and evading the host immune system, thus contributing to biofilm formation and virulence, and thus representing an ideal antifungal target. The emergence of azole resistance implies various and complex mechanisms that need to be further elucidated. Other important processes, such as biosynthetic pathways and toxin / metabolite production is important for fungal survival and propagation in the host environment, ultimately leading to disease. Moreover, the host immune response is a determinant factor in influencing the course of infection. The objective of this paper is to provide an overview of the pathogenesis to outline future research.
Author: Jean-Paul Latgé
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 612
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Book Description
Offers the latest insights into the fundamental biology and pathogenesis of A. fumigatus. Provides a combined synopsis of both A. fumigatus and its diseases and therapies. Encompasses the most up-to-date knowledge to serve as a resource guide for the next decade of study on this organism and the many diseases it causes. Covers the fundamental biology of A. fumigatus including specific features in genetics, biochemistry, and cell biology that can explain the virulence of this opportunistic pathogen. Discusses the wide range of clinical infection, plus the latest diagnostic and treatment strategies, in specific patient populations.
Author: Jagdish Chander
Publisher: JP Medical Ltd
ISBN: 9386261839
Category : Medical
Languages : en
Pages : 958
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Book Description
Medical mycology refers to the study of fungi that produce disease in humans and other animals, and of the diseases they produce, their ecology, and their epidemiology. This new edition has been fully revised to provide microbiologists with the latest information on fungal infections, covering the entire spectrum of different types of infection, and therapeutic modalities. Beginning with a general overview explaining morphology, taxonomy, and diagnosis, the following sections cover the different categories of fungal infection including superficial cutaneous mycoses, subcutaneous mycoses, systemic mycoses and opportunistic mycoses. A complete section is dedicated to pseudofungal infections. The highly illustrated text concludes with a detailed appendices section and each chapter features key references for further reading. Key points Fully revised, fourth edition providing latest information on the diagnosis and management of fungal infections Covers the entire spectrum of mycoses Highly illustrated with clinical photographs and figures Previous edition (9788188039780) published in 2009
Author: Héctor M. Mora-Montes
Publisher: Springer
ISBN: 3319641131
Category : Science
Languages : en
Pages : 431
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Book Description
Infections caused by fungi have recently attracted the attention of both clinicians and basic researchers given the heavy burden they represent for any health system. The mortality and morbidity rates associated to mycosis are progressively rising simply because some of these diseases are still neglected by health-care workers and due to the changing sensitivity to antifungal drugs displayed by these organisms. In this book, both researchers and clinicians working in the medical mycology field explore the most recent literature about specific mycosis; placing in one concise chapter thoroughly revisions of the current knowledge on virulence factors, recognition by immune cells, immunoevasion, epidemiology, new diagnosis trends and therapeutics. This book is recommended to researchers, physicians and students interested in medical mycology.
Author:
Publisher: ScholarlyEditions
ISBN: 1481610791
Category : Science
Languages : en
Pages : 71
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Book Description
Aspergillus—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Aspergillus in a concise format. The editors have built Aspergillus—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Aspergillus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aspergillus—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Jean-Paul Latgé
Publisher: Springer Nature
ISBN: 3030499286
Category : Science
Languages : en
Pages : 369
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Book Description
This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.
Author: Saurabh Saran
Publisher: John Wiley & Sons
ISBN: 1119460018
Category : Science
Languages : en
Pages : 476
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Book Description
Green technologies are no longer the “future” of science, but the present. With more and more mature industries, such as the process industries, making large strides seemingly every single day, and more consumers demanding products created from green technologies, it is essential for any business in any industry to be familiar with the latest processes and technologies. It is all part of a global effort to “go greener,” and this is nowhere more apparent than in fermentation technology. This book describes relevant aspects of industrial-scale fermentation, an expanding area of activity, which already generates commercial values of over one third of a trillion US dollars annually, and which will most likely radically change the way we produce chemicals in the long-term future. From biofuels and bulk amino acids to monoclonal antibodies and stem cells, they all rely on mass suspension cultivation of cells in stirred bioreactors, which is the most widely used and versatile way to produce. Today, a wide array of cells can be cultivated in this way, and for most of them genetic engineering tools are also available. Examples of products, operating procedures, engineering and design aspects, economic drivers and cost, and regulatory issues are addressed. In addition, there will be a discussion of how we got to where we are today, and of the real world in industrial fermentation. This chapter is exclusively dedicated to large-scale production used in industrial settings.
Author:
Publisher: Academic Press
ISBN: 0128120495
Category : Science
Languages : en
Pages : 212
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Book Description
Advances in Applied Microbiology, Volume 100 continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Current interventions for controlling pathogenic Escherichia coli, Microbial ecology and process technology of sourdough fermentation, Diversity, Application, and Synthetic Biology of Industrially Important Aspergillus Fungi, and Advances in the Microbial Ecology of Biohydrometallurgy. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Contains contributions from leading authorities Informs and updates on all the latest developments in the field Includes discussions on protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays and more
Author: Robert O. Williams
Publisher: CRC Press
ISBN: 1420043889
Category : Medical
Languages : en
Pages : 532
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Book Description
This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targ
Author: Vijai G. Gupta
Publisher: Elsevier
ISBN: 0444635122
Category : Technology & Engineering
Languages : en
Pages : 310
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Book Description
New and Future Developments in Microbial Biotechnology and Bioengineering: Penicillium System Properties and Applications covers important research work on the applications of penicillium from specialists from an international perspective. The book compiles advancements and ongoing processes in the penicillium system, along with updated information on the possibilities for future developments. All chapters are derived from current peer reviewed literature as accepted by the international scientific community. These important fungi were found to secrete a range of novel enzymes and other useful proteins, and are still being extensively studied and improved for specific use in the food, textile, pulp and paper, biocellulosic ethanol production and other industries. The book caters to the needs of researchers/academicians dealing with penicillium spp. related research and applications, outlining emerging issues on recent advancements made in the area of research and its applications in bioprocess technology, chemical engineering, molecular taxonomy, biofuels/bioenergy research and alternative fuel development. In addition, the book also describes the identification of useful compound combinations/enzyme cocktails and the fermentation conditions required to obtain them at an industrial scale. Finally, the book provides updated information on the best utilization of these fungi as a natural tool to meet the next challenges of biotechnology. Compiles the latest developments and current studies in the penicillium system Contains chapters contributed by top researchers with global appeal Includes current applications in bioindustry and lists future potential applications of these fungi species Identifies future research needs for these important fungi, including the best utilization of them as a natural tool to meet the next challenges of biotechnology
