Author: K.W. Allen
Publisher: Springer Science & Business Media
ISBN: 9400949383
Category : Science
Languages : en
Pages : 206
Book Description
The use of adhesives continues to increase both in importance and in areas of use, particularly in engineering construction. Alongside this is a steady growth in our fundamental understanding of the factors involved. Both of these topics are reflected in various meetings and nowhere more consistently than at the Annual Conference on Adhesion and Adhesives at The City University each Easter. 1984 was the twenty-second of these when, once again, people carne from far and near to present accounts of their work and to discuss them in all their variety. This publication makes the papers available to the wider audience who were not able to attend in person. In presenting this volume, may I express sincere gratitude, both personally and on behalf of the University, to all those who contributed in so many and various ways to the conference. K. W. ALLEN Contents Preface. v l. Textile-to-Rubber Adhesion: Theory and Practice David B. Wootton (Milliken Industrials Ltd, Wellington Mill, Wellington Street, Bury, Lancashire BL8 2AY, UK) 2. Aspects of Adhesion Promotion with Flexible Coated Fabrics 13 J. R. Holker and A. J. G. Sagar (Shirley Institute, Didsbury, Manchester M20 8RX, UK) 3. The Adhesion of Some Ethylene-Vinyl Acetate Copolymers Applied as Hot Melt Coatings to Metals 33 T. A. Hatzinikolaou and D. E. Packham (School of Materials Science, University of Bath, Claverton Down, Bath BA2 7 A Y, UK) 4. Formation of Indium Bonds for Ultrasonic Systems and Examination of Metal Diffusion Bonds by Scanning Acoustic Microscopy .
Adhesion 9
Author: K.W. Allen
Publisher: Springer Science & Business Media
ISBN: 9400949383
Category : Science
Languages : en
Pages : 206
Book Description
The use of adhesives continues to increase both in importance and in areas of use, particularly in engineering construction. Alongside this is a steady growth in our fundamental understanding of the factors involved. Both of these topics are reflected in various meetings and nowhere more consistently than at the Annual Conference on Adhesion and Adhesives at The City University each Easter. 1984 was the twenty-second of these when, once again, people carne from far and near to present accounts of their work and to discuss them in all their variety. This publication makes the papers available to the wider audience who were not able to attend in person. In presenting this volume, may I express sincere gratitude, both personally and on behalf of the University, to all those who contributed in so many and various ways to the conference. K. W. ALLEN Contents Preface. v l. Textile-to-Rubber Adhesion: Theory and Practice David B. Wootton (Milliken Industrials Ltd, Wellington Mill, Wellington Street, Bury, Lancashire BL8 2AY, UK) 2. Aspects of Adhesion Promotion with Flexible Coated Fabrics 13 J. R. Holker and A. J. G. Sagar (Shirley Institute, Didsbury, Manchester M20 8RX, UK) 3. The Adhesion of Some Ethylene-Vinyl Acetate Copolymers Applied as Hot Melt Coatings to Metals 33 T. A. Hatzinikolaou and D. E. Packham (School of Materials Science, University of Bath, Claverton Down, Bath BA2 7 A Y, UK) 4. Formation of Indium Bonds for Ultrasonic Systems and Examination of Metal Diffusion Bonds by Scanning Acoustic Microscopy .
Publisher: Springer Science & Business Media
ISBN: 9400949383
Category : Science
Languages : en
Pages : 206
Book Description
The use of adhesives continues to increase both in importance and in areas of use, particularly in engineering construction. Alongside this is a steady growth in our fundamental understanding of the factors involved. Both of these topics are reflected in various meetings and nowhere more consistently than at the Annual Conference on Adhesion and Adhesives at The City University each Easter. 1984 was the twenty-second of these when, once again, people carne from far and near to present accounts of their work and to discuss them in all their variety. This publication makes the papers available to the wider audience who were not able to attend in person. In presenting this volume, may I express sincere gratitude, both personally and on behalf of the University, to all those who contributed in so many and various ways to the conference. K. W. ALLEN Contents Preface. v l. Textile-to-Rubber Adhesion: Theory and Practice David B. Wootton (Milliken Industrials Ltd, Wellington Mill, Wellington Street, Bury, Lancashire BL8 2AY, UK) 2. Aspects of Adhesion Promotion with Flexible Coated Fabrics 13 J. R. Holker and A. J. G. Sagar (Shirley Institute, Didsbury, Manchester M20 8RX, UK) 3. The Adhesion of Some Ethylene-Vinyl Acetate Copolymers Applied as Hot Melt Coatings to Metals 33 T. A. Hatzinikolaou and D. E. Packham (School of Materials Science, University of Bath, Claverton Down, Bath BA2 7 A Y, UK) 4. Formation of Indium Bonds for Ultrasonic Systems and Examination of Metal Diffusion Bonds by Scanning Acoustic Microscopy .
Adhesion Science
Author: Steven Abbott
Publisher: DEStech Publications, Inc
ISBN: 1605951781
Category : Science
Languages : en
Pages : 319
Book Description
Explains the physics and chemistry of adhesion, surface preparation and testsPresents new strategies for formulating superior strong, weak and pressure-sensitive adhesivesIncludes access to unique electronic apps that enable numerical modeling of adhesives This technical bound book explains the basic principles of adhesion and shows how they are used to formulate and improve adhesives. The volume starts by laying out key physical and chemical concepts underlying adhesion and adhesives, including strong and weak bonds plus pressure-sensitive (PSA) across multiple polymer, metal and ceramic adherends. The ideas are expressed in clear and easily understood mathematical formulas that explain surface properties as well as "good" and "bad" adhesion, with the latter covering multiple types of adhesive failure. In this context, the book presents a detailed explanation of methods to predict, test and formulate adhesives and critically analyzes test results and traditionally accepted rules for adhesive formulation. The eBook version includes online access to a unique set of applied computer programs or "apps" that automate a wide range of adhesive formulas and enable readers to input their own data and numerically model adhesion properties in conjunction with, or prior to, chemical compounding and empirical testing. This volume constitutes a lucid and practical introduction to adhesion and adhesives appropriate for specialists at all levels.
Publisher: DEStech Publications, Inc
ISBN: 1605951781
Category : Science
Languages : en
Pages : 319
Book Description
Explains the physics and chemistry of adhesion, surface preparation and testsPresents new strategies for formulating superior strong, weak and pressure-sensitive adhesivesIncludes access to unique electronic apps that enable numerical modeling of adhesives This technical bound book explains the basic principles of adhesion and shows how they are used to formulate and improve adhesives. The volume starts by laying out key physical and chemical concepts underlying adhesion and adhesives, including strong and weak bonds plus pressure-sensitive (PSA) across multiple polymer, metal and ceramic adherends. The ideas are expressed in clear and easily understood mathematical formulas that explain surface properties as well as "good" and "bad" adhesion, with the latter covering multiple types of adhesive failure. In this context, the book presents a detailed explanation of methods to predict, test and formulate adhesives and critically analyzes test results and traditionally accepted rules for adhesive formulation. The eBook version includes online access to a unique set of applied computer programs or "apps" that automate a wide range of adhesive formulas and enable readers to input their own data and numerically model adhesion properties in conjunction with, or prior to, chemical compounding and empirical testing. This volume constitutes a lucid and practical introduction to adhesion and adhesives appropriate for specialists at all levels.
Handbook of Wood Chemistry and Wood Composites
Author: Roger M. Rowell
Publisher: CRC Press
ISBN: 0203492439
Category : Science
Languages : en
Pages : 505
Book Description
The degradable nature of high-performance, wood-based materials is an attractive advantage when considering environmental factors such as sustainability, recycling, and energy/resource conservation. The Handbook of Wood Chemistry and Wood Composites provides an excellent guide to the latest concepts and technologies in wood chemistry and bio-based composites. The book analyzes the chemical composition and physical properties of wood cellulose and its response to natural processes of degradation. It describes safe and effective chemical modifications to strengthen wood against biological, chemical, and mechanical degradation without using toxic, leachable, or corrosive chemicals. Expert researchers provide insightful analyses of the types of chemical modifications applied to polymer cell walls in wood, emphasizing the mechanisms of reaction involved and resulting changes in performance properties. These include modifications that increase water repellency, fire retardancy, and resistance to ultraviolet light, heat, moisture, mold, and other biological organisms. The text also explores modifications that increase mechanical strength, such as lumen fill, monomer polymer penetration, and plasticization. The Handbook of Wood Chemistry and Wood Composites concludes with the latest applications, such as adhesives, geotextiles, and sorbents, and future trends in the use of wood-based composites in terms of sustainable agriculture, biodegradability and recycling, and economics. Incorporating over 30 years of teaching experience, the esteemed editor of this handbook is well-attuned to educational demands as well as industry standards and research trends.
Publisher: CRC Press
ISBN: 0203492439
Category : Science
Languages : en
Pages : 505
Book Description
The degradable nature of high-performance, wood-based materials is an attractive advantage when considering environmental factors such as sustainability, recycling, and energy/resource conservation. The Handbook of Wood Chemistry and Wood Composites provides an excellent guide to the latest concepts and technologies in wood chemistry and bio-based composites. The book analyzes the chemical composition and physical properties of wood cellulose and its response to natural processes of degradation. It describes safe and effective chemical modifications to strengthen wood against biological, chemical, and mechanical degradation without using toxic, leachable, or corrosive chemicals. Expert researchers provide insightful analyses of the types of chemical modifications applied to polymer cell walls in wood, emphasizing the mechanisms of reaction involved and resulting changes in performance properties. These include modifications that increase water repellency, fire retardancy, and resistance to ultraviolet light, heat, moisture, mold, and other biological organisms. The text also explores modifications that increase mechanical strength, such as lumen fill, monomer polymer penetration, and plasticization. The Handbook of Wood Chemistry and Wood Composites concludes with the latest applications, such as adhesives, geotextiles, and sorbents, and future trends in the use of wood-based composites in terms of sustainable agriculture, biodegradability and recycling, and economics. Incorporating over 30 years of teaching experience, the esteemed editor of this handbook is well-attuned to educational demands as well as industry standards and research trends.
Adhesion and Adhesives
Author: Anthony J. Kinloch
Publisher: Springer Science & Business Media
ISBN: 9401577641
Category : Technology & Engineering
Languages : en
Pages : 452
Book Description
Over the last decade, or so, the growth in the use of adhesives, especially in ever more technically demanding applications, has been rapid and many major developments in the technology of adhesives have been reported. This growth has also led to attention being focused on somewhat more basic studies of the science of adhesion and adhesives, and in recent years our level of fundamental knowledge concerning the formation and mechanical performance of adhesive joints has increased dramatically. Such studies have, of course, been aided greatly by the development of the tools at the disposal of the investigators. For example, specific surface analytical techniques, such as X-ray photoelectron and secondary-ion mass spectroscopy, and the increasingly sophisticated methods of stress analysis and fracture mechanics have been put to good use in furthering our understanding of the science of adhesion and adhesives. The present book attempts to review the multidisciplined subject of adhesion and adhesives, considering both the science and technology involved in the formation and mechanical performance of adhesive joints. The author would like to thank his friends and colleagues for useful discus sions and help in the preparation of this book. I am particularly grateful to P. Cawley, J. Comyn, W. A. Lees, A. C. Roulin-Moloney, W. C. Wake, J. G. Williams and R. J. Young who have read and commented on various chapters and P. Farr for preparing the diagrams.
Publisher: Springer Science & Business Media
ISBN: 9401577641
Category : Technology & Engineering
Languages : en
Pages : 452
Book Description
Over the last decade, or so, the growth in the use of adhesives, especially in ever more technically demanding applications, has been rapid and many major developments in the technology of adhesives have been reported. This growth has also led to attention being focused on somewhat more basic studies of the science of adhesion and adhesives, and in recent years our level of fundamental knowledge concerning the formation and mechanical performance of adhesive joints has increased dramatically. Such studies have, of course, been aided greatly by the development of the tools at the disposal of the investigators. For example, specific surface analytical techniques, such as X-ray photoelectron and secondary-ion mass spectroscopy, and the increasingly sophisticated methods of stress analysis and fracture mechanics have been put to good use in furthering our understanding of the science of adhesion and adhesives. The present book attempts to review the multidisciplined subject of adhesion and adhesives, considering both the science and technology involved in the formation and mechanical performance of adhesive joints. The author would like to thank his friends and colleagues for useful discus sions and help in the preparation of this book. I am particularly grateful to P. Cawley, J. Comyn, W. A. Lees, A. C. Roulin-Moloney, W. C. Wake, J. G. Williams and R. J. Young who have read and commented on various chapters and P. Farr for preparing the diagrams.
Adhesion Science and Engineering
Author:
Publisher: Elsevier
ISBN: 0080525989
Category : Science
Languages : en
Pages : 2020
Book Description
The Mechanics of Adhesion shows that adhesion science and technology is inherently an interdisciplinary field, requiring fundamental understanding of mechanics, surfaces, and materials. This volume comprises 19 chapters. Starting with a background and introduction to stress transfer principles; fracture mechanics and singularities; and an energy approach to debonding, the volume continues with analysis of structural lap and butt joint configurations. It then continues with discussions of test methods for strength and constitutive properties; fracture; peel; coatings, the case of adhesion to a single substrate; elastomeric adhesives such as sealants. The role of mechanics in determining the locus of failure in bonded joints is discussed, followed by a chapter on rheology relevant to adhesives and sealants. Pressure sensitive adhesive performance; the principles of tack and tack measurements; and contact mechanics relevant to wetting and surface energy measurements are then covered. The volume concludes with sections on fibermatrix bonding and reinforcement; durability considerations for adhesive bonds; ultrasonic non-destructive evaluation of adhesive bonds; and design of adhesive bonds from a strength perspective. This book will be of interest to practitioners in the fields of engineering and to those with an interest in adhesion science.
Publisher: Elsevier
ISBN: 0080525989
Category : Science
Languages : en
Pages : 2020
Book Description
The Mechanics of Adhesion shows that adhesion science and technology is inherently an interdisciplinary field, requiring fundamental understanding of mechanics, surfaces, and materials. This volume comprises 19 chapters. Starting with a background and introduction to stress transfer principles; fracture mechanics and singularities; and an energy approach to debonding, the volume continues with analysis of structural lap and butt joint configurations. It then continues with discussions of test methods for strength and constitutive properties; fracture; peel; coatings, the case of adhesion to a single substrate; elastomeric adhesives such as sealants. The role of mechanics in determining the locus of failure in bonded joints is discussed, followed by a chapter on rheology relevant to adhesives and sealants. Pressure sensitive adhesive performance; the principles of tack and tack measurements; and contact mechanics relevant to wetting and surface energy measurements are then covered. The volume concludes with sections on fibermatrix bonding and reinforcement; durability considerations for adhesive bonds; ultrasonic non-destructive evaluation of adhesive bonds; and design of adhesive bonds from a strength perspective. This book will be of interest to practitioners in the fields of engineering and to those with an interest in adhesion science.
Adhesion and Adhesives Technology
Author: Alphonsus V. Pocius
Publisher: Hanser Gardner Publications
ISBN: 9781569903193
Category : Technology & Engineering
Languages : en
Pages : 319
Book Description
This book describes, in clear, understandable language, the three main disciplines of adhesion technology:
Publisher: Hanser Gardner Publications
ISBN: 9781569903193
Category : Technology & Engineering
Languages : en
Pages : 319
Book Description
This book describes, in clear, understandable language, the three main disciplines of adhesion technology:
Adhesion Science
Author: John Comyn
Publisher: Royal Society of Chemistry
ISBN: 1847550061
Category : Technology & Engineering
Languages : en
Pages : 162
Book Description
The use of adhesives is widespread and growing, and there are few modern artefacts, from the simple cereal packet, to the jumbo jet, that are without this means of joining. Adhesion Science provides an illuminating account of the science underlying the use of adhesives, a branch of chemical technology which is fundamental to the science of coatings and composite materials and to the performance of all types of bonded structures. This book guides the reader through the essential basic polymer science, and the chemistry of adhesives in use at present. It discusses surface preparation for adhesive bonding, and the use of primers and coupling agents. There is a detailed chapter on contact angles and what can be predicted from them. A simple guide on stress distribution joints and how this relates to testing is included. It also examines the interaction of adhesives and the environment, including an analysis of the resistance of joints to water, oxygen and ultra-violet light. Adhesion Science provides a comprehensive introduction to the chemistry of adhesives, and will be of interest not only to chemists, but also to readers with a background in physical or materials science.
Publisher: Royal Society of Chemistry
ISBN: 1847550061
Category : Technology & Engineering
Languages : en
Pages : 162
Book Description
The use of adhesives is widespread and growing, and there are few modern artefacts, from the simple cereal packet, to the jumbo jet, that are without this means of joining. Adhesion Science provides an illuminating account of the science underlying the use of adhesives, a branch of chemical technology which is fundamental to the science of coatings and composite materials and to the performance of all types of bonded structures. This book guides the reader through the essential basic polymer science, and the chemistry of adhesives in use at present. It discusses surface preparation for adhesive bonding, and the use of primers and coupling agents. There is a detailed chapter on contact angles and what can be predicted from them. A simple guide on stress distribution joints and how this relates to testing is included. It also examines the interaction of adhesives and the environment, including an analysis of the resistance of joints to water, oxygen and ultra-violet light. Adhesion Science provides a comprehensive introduction to the chemistry of adhesives, and will be of interest not only to chemists, but also to readers with a background in physical or materials science.
Handbook of Adhesion
Author: D. E. Packham
Publisher: John Wiley & Sons
ISBN: 0470014210
Category : Technology & Engineering
Languages : en
Pages : 692
Book Description
This second edition of the successful Handbook of Adhesion provides concise and authoritative articles covering many aspects of the science and technology associated with adhesion and adhesives. It is intended to fill a gap between the necessarily simplified treatment of the student textbook and the full and thorough treatment of the research monograph and review article. The articles are structured in such a way, with internal cross-referencing and external literature references, that the reader can build up a broader and deeper understanding, as their needs require. This second edition includes many new articles covering developments which have risen in prominence in the intervening years, such as scanning probe techniques, the surface forces apparatus and the relation between adhesion and fractal surfaces. Advances in understanding polymer - polymer interdiffusion are reflected in articles drawing out the implications for adhesive bonding. In addition, articles derived from the earlier edition have been revised and updated where needed. Throughout the book there is a renewed emphasis on environmental implications of the use of adhesives and sealants. The scope of the Handbook, which features nearly 250 articles from over 60 authors, includes the background science - physics, chemistry and material science - and engineering, and also aspects of adhesion relevant to the use of adhesives, including topics such as: Sealants and mastics Paints and coatings Printing and composite materials Welding and autohesion Engineering design The Handbook of Adhesion is intended for scientists and engineers in both academia and industry, requiring an understanding of the various facets of adhesion.
Publisher: John Wiley & Sons
ISBN: 0470014210
Category : Technology & Engineering
Languages : en
Pages : 692
Book Description
This second edition of the successful Handbook of Adhesion provides concise and authoritative articles covering many aspects of the science and technology associated with adhesion and adhesives. It is intended to fill a gap between the necessarily simplified treatment of the student textbook and the full and thorough treatment of the research monograph and review article. The articles are structured in such a way, with internal cross-referencing and external literature references, that the reader can build up a broader and deeper understanding, as their needs require. This second edition includes many new articles covering developments which have risen in prominence in the intervening years, such as scanning probe techniques, the surface forces apparatus and the relation between adhesion and fractal surfaces. Advances in understanding polymer - polymer interdiffusion are reflected in articles drawing out the implications for adhesive bonding. In addition, articles derived from the earlier edition have been revised and updated where needed. Throughout the book there is a renewed emphasis on environmental implications of the use of adhesives and sealants. The scope of the Handbook, which features nearly 250 articles from over 60 authors, includes the background science - physics, chemistry and material science - and engineering, and also aspects of adhesion relevant to the use of adhesives, including topics such as: Sealants and mastics Paints and coatings Printing and composite materials Welding and autohesion Engineering design The Handbook of Adhesion is intended for scientists and engineers in both academia and industry, requiring an understanding of the various facets of adhesion.
Surface Preparation Techniques for Adhesive Bonding
Author: Raymond F. Wegman
Publisher: William Andrew
ISBN: 1455731285
Category : Technology & Engineering
Languages : en
Pages : 167
Book Description
Surface Preparation Techniques for Adhesive Bonding is an essential guide for materials scientists, mechanical engineers, plastics engineers, scientists and researchers in manufacturing environments making use of adhesives technology. Wegman and van Twisk provide practical coverage of a topic that receives only cursory treatment in more general books on adhesives, making this book essential reading for adhesion specialists, plastics engineers, and a wide range of engineers and scientists working in sectors where adhesion is an important technology, e.g. automotive / aerospace, medical devices, electronics. Wegman and van Twisk provide a wealth of practical information on the processing of substrate surfaces prior to adhesive bonding. The processing of aluminum and its alloys, titanium and its alloys, steels, copper and its alloys, and magnesium are treated in the form of detailed specifications with comparative data. Other metals not requiring extensive treatment are also covered in detail, as are metal matrix and organic matrix composites, thermosets and thermoplastics. This new edition has been updated with coverage of the latest developments in the field including the sol-gel process for aluminum, titanium, and stainless steel, atmospheric plasma treatment for metals, plastics and rubbers and treatments for bronze and nickel alloys. - Updated to include recent technological developments and chemicals currently prescribed for cleaning and surface preparation; a new generation of adhesives technologists can benefit from this classic guide - Enables Materials and Process personnel to select the best process available for their particular application - Practical coverage of a topic that receives only cursory coverage in more general books on adhesives: essential reading for adhesion specialists, plastics engineers, and a wide range of engineers and scientists working in sectors where adhesion is an important technology, e.g. automotive / aerospace, medical devices, electronics
Publisher: William Andrew
ISBN: 1455731285
Category : Technology & Engineering
Languages : en
Pages : 167
Book Description
Surface Preparation Techniques for Adhesive Bonding is an essential guide for materials scientists, mechanical engineers, plastics engineers, scientists and researchers in manufacturing environments making use of adhesives technology. Wegman and van Twisk provide practical coverage of a topic that receives only cursory treatment in more general books on adhesives, making this book essential reading for adhesion specialists, plastics engineers, and a wide range of engineers and scientists working in sectors where adhesion is an important technology, e.g. automotive / aerospace, medical devices, electronics. Wegman and van Twisk provide a wealth of practical information on the processing of substrate surfaces prior to adhesive bonding. The processing of aluminum and its alloys, titanium and its alloys, steels, copper and its alloys, and magnesium are treated in the form of detailed specifications with comparative data. Other metals not requiring extensive treatment are also covered in detail, as are metal matrix and organic matrix composites, thermosets and thermoplastics. This new edition has been updated with coverage of the latest developments in the field including the sol-gel process for aluminum, titanium, and stainless steel, atmospheric plasma treatment for metals, plastics and rubbers and treatments for bronze and nickel alloys. - Updated to include recent technological developments and chemicals currently prescribed for cleaning and surface preparation; a new generation of adhesives technologists can benefit from this classic guide - Enables Materials and Process personnel to select the best process available for their particular application - Practical coverage of a topic that receives only cursory coverage in more general books on adhesives: essential reading for adhesion specialists, plastics engineers, and a wide range of engineers and scientists working in sectors where adhesion is an important technology, e.g. automotive / aerospace, medical devices, electronics
Inflammation and the Microcirculation
Author: D. Neil Granger
Publisher: Morgan & Claypool Publishers
ISBN: 1615041656
Category : Medical
Languages : en
Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Publisher: Morgan & Claypool Publishers
ISBN: 1615041656
Category : Medical
Languages : en
Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References