A Mutation-Selection Model with Recombination for General Genotypes PDF Download
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Author: Steven Neil Evans
Publisher: American Mathematical Soc.
ISBN: 0821875698
Category : Mathematics
Languages : en
Pages : 142
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Book Description
The authors investigate a continuous time, probability measure-valued dynamical system that describes the process of mutation-selection balance in a context where the population is infinite, there may be infinitely many loci, and there are weak assumptions on selective costs. Their model arises when they incorporate very general recombination mechanisms into an earlier model of mutation and selection presented by Steinsaltz, Evans and Wachter in 2005 and take the relative strength of mutation and selection to be sufficiently small. The resulting dynamical system is a flow of measures on the space of loci. Each such measure is the intensity measure of a Poisson random measure on the space of loci: the points of a realization of the random measure record the set of loci at which the genotype of a uniformly chosen individual differs from a reference wild type due to an accumulation of ancestral mutations. The authors' motivation for working in such a general setting is to provide a basis for understanding mutation-driven changes in age-specific demographic schedules that arise from the complex interaction of many genes, and hence to develop a framework for understanding the evolution of aging.
Author: Steven Neil Evans
Publisher: American Mathematical Soc.
ISBN: 0821875698
Category : Mathematics
Languages : en
Pages : 142
Get Book Here
Book Description
The authors investigate a continuous time, probability measure-valued dynamical system that describes the process of mutation-selection balance in a context where the population is infinite, there may be infinitely many loci, and there are weak assumptions on selective costs. Their model arises when they incorporate very general recombination mechanisms into an earlier model of mutation and selection presented by Steinsaltz, Evans and Wachter in 2005 and take the relative strength of mutation and selection to be sufficiently small. The resulting dynamical system is a flow of measures on the space of loci. Each such measure is the intensity measure of a Poisson random measure on the space of loci: the points of a realization of the random measure record the set of loci at which the genotype of a uniformly chosen individual differs from a reference wild type due to an accumulation of ancestral mutations. The authors' motivation for working in such a general setting is to provide a basis for understanding mutation-driven changes in age-specific demographic schedules that arise from the complex interaction of many genes, and hence to develop a framework for understanding the evolution of aging.
Author: R. S. Singh
Publisher: Cambridge University Press
ISBN: 9780521571234
Category : Medical
Languages : en
Pages : 738
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Book Description
This book brings out the central role of evolutionary genetics in all aspects of its connection to evolutionary biology.
Author: Rama S. Singh
Publisher: Oxford University Press, USA
ISBN: 0199642273
Category : Medical
Languages : en
Pages : 309
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Book Description
A range of theories on the rates of evolution-from static to gradual to punctuated to quantum-have been developed, mostly by comparing morphological changes over geological timescales as described in the fossil record.
Author: Brian Charlesworth
Publisher: Roberts
ISBN:
Category : Science
Languages : en
Pages : 776
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Book Description
This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.
Author: John Maynard Smith
Publisher: Cambridge University Press
ISBN: 9780521218870
Category : Science
Languages : en
Pages : 236
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Book Description
The question of why organisms reproduce sexually is still a matter of controversy. In this account, Professor Maynard Smith considers the selective forces responsible for the origin and evolution of sexual reproduction and genetic recombination, using quantitative population genetics arguments to support his ideas. The relative importance of individual and group selection processes are also considered. the aim is to give a clear statement of the theoretical issues, and present enough of the evidence to show what kinds of facts are relevant. It is hoped that where crucial evidence is missing, experimentalists and field workers may be encouraged to collect the relevant data. The author does not claim to solve all the problems he raises, but this clear and well-argued account should provide stimulating reading for advanced undergraduate students and research workers in evolutionary theory.
Author:
Publisher: World Scientific
ISBN:
Category :
Languages : en
Pages : 1131
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Book Description
Author: John C. Sanford
Publisher:
ISBN: 9780981631608
Category : Nature
Languages : en
Pages : 0
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Book Description
In this text, Sanford, a retired Cornell professor, shows that the "Primary Axiom"--the foundational evolutionary premise that life is merely the result of mutations and natural selection--is false. He strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process.
Author: Julien Y Dutheil
Publisher:
ISBN: 9781013271403
Category : Science
Languages : en
Pages : 464
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Book Description
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Ronny C. Woodruff
Publisher: Springer Science & Business Media
ISBN: 9401152101
Category : Science
Languages : en
Pages : 561
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Book Description
Although debated since the time of Darwin, the evolutionary role of mutation is still controversial. In over 40 chapters from leading authorities in mutation and evolutionary biology, this book takes a new look at both the theoretical and experimental measurement and significance of new mutation. Deleterious, nearly neutral, beneficial, and polygenic mutations are considered in their effects on fitness, life history traits, and the composition of the gene pool. Mutation is a phenomenon that draws attention from many different disciplines. Thus, the extensive reviews of the literature will be valuable both to established researchers and to those just beginning to study this field. Through up-to-date reviews, the authors provide an insightful overview of each topic and then share their newest ideas and explore controversial aspects of mutation and the evolutionary process. From topics like gonadal mosaicism and mutation clusters to adaptive mutagenesis, mutation in cell organelles, and the level and distribution of DNA molecular changes, the foundation is set for continuing the debate about the role of mutation, fitness, and adaptability. It is a debate that will have profound consequences for our understanding of evolution.
Author: Alan R. Templeton
Publisher: Academic Press
ISBN: 0123860261
Category : Science
Languages : en
Pages : 500
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Book Description
Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. - Comprehensively explains the use of population genetics and genomics in medical applications and research - Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals - Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
