A Hybrid Case-based Reasoning Clinical Decision Support System for Treatment-planning of Bone Tissue Engineering and Regenerative Medicine Approaches PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download A Hybrid Case-based Reasoning Clinical Decision Support System for Treatment-planning of Bone Tissue Engineering and Regenerative Medicine Approaches PDF full book. Access full book title A Hybrid Case-based Reasoning Clinical Decision Support System for Treatment-planning of Bone Tissue Engineering and Regenerative Medicine Approaches by James Wright. Download full books in PDF and EPUB format.
Author: James Wright
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: James Wright
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Robert Greenes
Publisher: Elsevier
ISBN: 0080467695
Category : Science
Languages : en
Pages : 599
Get Book Here
Book Description
This book examines the nature of medical knowledge, how it is obtained, and how it can be used for decision support. It provides complete coverage of computational approaches to clinical decision-making. Chapters discuss data integration into healthcare information systems and delivery to point of care for providers, as well as facilitation of direct to consumer access. A case study section highlights critical lessons learned, while another portion of the work examines biostatistical methods including data mining, predictive modelling, and analysis. This book additionally addresses organizational, technical, and business challenges in order to successfully implement a computer-aided decision-making support system in healthcare delivery.
Author: Hala Zreiqat
Publisher: Springer
ISBN: 3319132660
Category : Technology & Engineering
Languages : en
Pages : 257
Get Book Here
Book Description
Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.
Author: Martin Peeker
Publisher:
ISBN:
Category :
Languages : en
Pages : 54
Get Book Here
Book Description
Author: Phuc Van Pham
Publisher: Springer
ISBN: 9783319401430
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
Author: Luis M. Ahumada
Publisher:
ISBN:
Category : Bioinformatics
Languages : en
Pages : 392
Get Book Here
Book Description
Physicians are constantly faced with making decisions under uncertainty, and despite the extraordinary advancements in the field of clinical informatics, there is a significant void about how to build simple and trustworthy clinical decision support systems. This dissertation focusses on investigating whether a hybrid recommender framework approach can exceed conventional data analysis techniques in order to provide physicians with accurate insights. The research questions explored a novel hybrid recommender framework that improves upon common clinical recommendation practices such as data driven, case base reasoning and machine learning techniques by integrating them into a unified data model. Conceptually this study was framed within theories of probability, numerical analysis, case base reasoning, machine learning, clinical decision support and recommendation systems. Experiments demonstrate that the proposed hybrid recommender framework is more accurate and effective than common baseline techniques. We evaluate the framework by implementing a prototype and experimenting with an outstanding clinical problem: how to reduce the number of unnecessary pre-operative blood tests for pediatric neurosurgical patients. We analyze heterogeneous databases containing 359,475 patient encounters at The Children's Hospital of Philadelphia from 2001 to 2014. Experimental analysis shows that our hybrid approach has a sensitivity of 0.80, a specificity of 0.85 and a mean absolute error of 0.875. Finally, we demonstrate preliminary results of a real-world implementation by embedding the recommendations into the physician's workflow in the production environment of the hospital's electronic health record. The application shows a reduction of ordering unnecessary tests by ~ 25% in the first quarter of 2016 and a 100% adoption rate by the user base. This result suggests that our approach helps in improving the quality of physician's decisions with a positive impact on outcomes.
Author: Ulrich Meyer
Publisher: Springer Science & Business Media
ISBN: 3540777555
Category : Medical
Languages : en
Pages : 1049
Get Book Here
Book Description
"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.
Author: Jancy C. McPhee
Publisher: U. S. National Aeronautics & Space Administration
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 396
Get Book Here
Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309670489
Category : Medical
Languages : en
Pages : 427
Get Book Here
Book Description
Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.
Author: Mihail C. Roco
Publisher: Springer Science & Business Media
ISBN: 9401703590
Category : Technology & Engineering
Languages : en
Pages : 477
Get Book Here
Book Description
M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
