A Genetic and Molecular Analysis of Neuromuscular Connectivity in Drosophila Melanogaster PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download A Genetic and Molecular Analysis of Neuromuscular Connectivity in Drosophila Melanogaster PDF full book. Access full book title A Genetic and Molecular Analysis of Neuromuscular Connectivity in Drosophila Melanogaster by Douglas McIntosh Fambrough. Download full books in PDF and EPUB format.
Author: Douglas McIntosh Fambrough
Publisher:
ISBN:
Category :
Languages : en
Pages : 526
Get Book Here
Book Description
Author: Douglas McIntosh Fambrough
Publisher:
ISBN:
Category :
Languages : en
Pages : 526
Get Book Here
Book Description
Author: Hong Iris Wan
Publisher:
ISBN:
Category :
Languages : en
Pages : 392
Get Book Here
Book Description
Author:
Publisher: Academic Press
ISBN: 0080857779
Category : Science
Languages : en
Pages : 317
Get Book Here
Book Description
Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories.Key Features* Synthesizes the genetic approaches used to study synaptic development and function at the neuromuscular junction, using flies as a model system* Covers major recent advances in muscle development, pathfinding, synapse maturation and plasticity, exo- and endocytosis, and ion channel function* Written in clear language that is easily understandable to readers not already familiar with fruit fly research* Includes numerous diagrams and extensive reference lists
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 292
Get Book Here
Book Description
Although evolution of brains and behaviors is of fundamental biological importance, we lack comprehensive understanding of the general principles governing these processes or the specific mechanisms and molecules through which the evolutionary changes are effected. Because synapses are the basic structural and functional units of nervous systems, one way to address these problems is to dissect the genetic and molecular pathways responsible for morphological evolution of a defined synapse. I have undertaken such an analysis by examining morphology of the larval neuromuscular junction (NMJ) in wild caught D. melanogaster as well as in over 20 other species of Drosophila. Whereas variation in NMJ morphology within a species is limited, I discovered a surprisingly extensive variation among different species. Compared with evolution of other morphological traits, NMJ morphology appears to be evolving very rapidly. Moreover, my data indicate that natural selection rather than genetic drift is primarily responsible for evolution of NMJ morphology. To dissect underlying molecular mechanisms that may govern NMJ growth and evolutionary divergence, I focused on a naturally occurring variant in D. melanogaster that causes NMJ overgrowth. I discovered that the variant mapped to Mob2, a gene encoding a kinase adapter protein originally described in yeast as a member of the Mitotic Exit Network (MEN). I have subsequently examined mutations in the Drosophila orthologs of all the core components of the yeast MEN and found that all of them function as part of a common pathway that acts presynaptically to negatively regulate NMJ growth. As in the regulation of yeast cytokinesis, these components of the MEN appear to act ultimately by regulating actin dynamics during the process of bouton growth and division. These studies have thus led to the discovery of an entirely new role for the MEN--regulation of synaptic growth--that is separate from its function in cell division. This work has identified a rich source of material for discovery of novel genes and mechanisms that regulate synaptic growth and development, and has also provided new insights into the mechanisms that underlie morphological evolution of nervous systems.
Author: Song Hu
Publisher:
ISBN:
Category :
Languages : en
Pages : 406
Get Book Here
Book Description
Author: Birong Hu
Publisher:
ISBN:
Category :
Languages : en
Pages : 290
Get Book Here
Book Description
Author: Lauryl M. J. Nutter
Publisher:
ISBN:
Category :
Languages : en
Pages : 156
Get Book Here
Book Description
Author: Helen Sink
Publisher: Springer Science & Business Media
ISBN: 9780387300535
Category : Science
Languages : en
Pages : 224
Get Book Here
Book Description
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Author: Mary J. Stewart
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
Get Book Here
Book Description
Author: Mahua Mukhopadhyay
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 400
Get Book Here
Book Description
