Author: Mathias Elgland
Publisher: Linköping University Electronic Press
ISBN: 9176853764
Category :
Languages : en
Pages : 125
Book Description
Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Synthesis and application of ?-configured [18/19F]FDGs
Author: Mathias Elgland
Publisher: Linköping University Electronic Press
ISBN: 9176853764
Category :
Languages : en
Pages : 125
Book Description
Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Publisher: Linköping University Electronic Press
ISBN: 9176853764
Category :
Languages : en
Pages : 125
Book Description
Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Investigation of the Assassination of President John F. Kennedy: September 18, 19, 20, and 21, 1978
Author: United States. Congress. House. Select Committee on Assassinations
Publisher:
ISBN:
Category :
Languages : en
Pages : 764
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 764
Book Description
Flood on Piney River, November 18-19, 1957, in Vicinity of Spring City, Tennessee
Author: Tennessee Valley Authority. Division of Water Control Planning
Publisher:
ISBN:
Category : Floods
Languages : en
Pages : 134
Book Description
Publisher:
ISBN:
Category : Floods
Languages : en
Pages : 134
Book Description
Annals of the New York Academy of Sciences
Author: New York Academy of Sciences
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 596
Book Description
Records of meetings 1808-1916 in v. 11-27.
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 596
Book Description
Records of meetings 1808-1916 in v. 11-27.
The Jersey Bulletin and Dairy World
Author:
Publisher:
ISBN:
Category : Dairying
Languages : en
Pages : 906
Book Description
Publisher:
ISBN:
Category : Dairying
Languages : en
Pages : 906
Book Description
Journal of the Royal Statistical Society
Author: Royal Statistical Society (Great Britain)
Publisher:
ISBN:
Category : Electronic journals
Languages : en
Pages : 932
Book Description
Published papers whose appeal lies in their subject-matter rather than their technical statistical contents. Medical, social, educational, legal,demographic and governmental issues are of particular concern.
Publisher:
ISBN:
Category : Electronic journals
Languages : en
Pages : 932
Book Description
Published papers whose appeal lies in their subject-matter rather than their technical statistical contents. Medical, social, educational, legal,demographic and governmental issues are of particular concern.
A Manual for the Use of the General Court
Author: Massachusetts. General Court
Publisher:
ISBN:
Category : Massachusetts
Languages : en
Pages : 778
Book Description
Contains rules of both branches of the General Court, the constitution of the commonwealth and that of the United States, lists of executive, legislative and judicial departments of the state, etc.
Publisher:
ISBN:
Category : Massachusetts
Languages : en
Pages : 778
Book Description
Contains rules of both branches of the General Court, the constitution of the commonwealth and that of the United States, lists of executive, legislative and judicial departments of the state, etc.
Vocational and Occupational Education: Hearings held in Washington D.C., February 18, 19, 25, 26 .... vol. 2. Hearings held in Washington, D.C. March 20, 25 26 .... vol. 3. Hearings held in Springfield, Ill., September 15, 1975; Cedar Rapids, Iowa, September 16, 1975
Author: United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education
Publisher:
ISBN:
Category : Vocational education
Languages : en
Pages : 782
Book Description
Publisher:
ISBN:
Category : Vocational education
Languages : en
Pages : 782
Book Description
Annual and Biennial Reports for ... Made to the ... General Assembly of the State of Ohio
Author: Ohio
Publisher:
ISBN:
Category : Ohio
Languages : en
Pages : 934
Book Description
Publisher:
ISBN:
Category : Ohio
Languages : en
Pages : 934
Book Description
Legislative Document
Author: New York (State). Legislature
Publisher:
ISBN:
Category : New York (State)
Languages : en
Pages : 1020
Book Description
Publisher:
ISBN:
Category : New York (State)
Languages : en
Pages : 1020
Book Description